PUBLISHER: DataM Intelligence | PRODUCT CODE: 1179851
PUBLISHER: DataM Intelligence | PRODUCT CODE: 1179851
The global aminophenol market reached US$ XX million in 2021 and is expected to record significant growth by reaching up to US$ XX million by 2029, growing at a CAGR of YY% during the forecast period (2022-2029).
Commercially, aminophenols and their derivatives are significant both on their own and as building blocks for the chemical coloring, pharmaceutical and photography industries. Although they can act as weak bases or acids due to their amphoteric nature, the basic character typically prevails.
In contrast to 2-aminophenol and 4-aminophenol, which are easily oxidized to colorful compounds, 3-aminophenol is very stable in the air. In contrast to the former, typically converted to their acid counterparts, 4-aminophenol is frequently prepared with low amounts of antioxidants that serve as inhibitors against unwelcome oxidation. Depending on the relative locations of the amino and hydroxyl groups around the benzene ring, the simple aminophenols can be found in three isomeric forms.
A variety of cyclization processes are performed on aminophenol. Alkylation, acylation, diazonium salt production, cyclization, condensation and benzene ring reactions are significant. Either nitrophenol are reduced to aminophenols or aminophenols are substituted. In the presence of a catalyst, the reduction is carried out using hydrogen or iron.
Growing demand for paracetamol globally is a pivotal factor driving the demand for aminophenols in the global market. However, health problems associated with aminophenol and stringent regulations could be a major market restraint.
Growing demand for paracetamol globally
Due to the increased incidence of chronic diseases and other ailments that necessitate ongoing pain management treatments, the global market for para-aminophenol (PAP) and paracetamol has experienced significant growth. The primary driver of paracetamol consumption worldwide is the growing understanding of the pain treatment options paracetamol provides, making it an effective analgesic.
Statistics indicate that the fastest-growing pharmaceutical compounds are those that have gained momentum throughout the past two years of the pandemic. Paracetamol is one of the pharmaceuticals that registered a high double-digit compound annual growth rate (CAGR) over the previous five years, according to an analysis of the top 20 pharmacological molecules in the global market. According to research, the CAGR for paracetamol, a medication practically all COVID-19 patients were prescribed, was 21.4 percent between 2017 and 2021. These acute treatment medications, including paracetamol and azithromycin, saw significant growth under Covid19. According to IQVIA data, Dolo, a brand of paracetamol, ranked third among the best-selling pharmaceutical brands in January 2022 with sales of US$ 77,23,244 (INR 64 crore), an increase of 307 percent.
Since about 80% of p-aminophenol generated worldwide is used to make paracetamol, the rising demand for the latter is directly affecting the growth of the global aminophenol market. Therefore, the respective fact could be recognized as a major market driver for the global aminophenol market.
The health complications associated with aminophenol and the stringent regulations associated with its manufacture
Aminophenols may be absorbed through the skin and may have an impact when breathed in. On contact, aminophenols can irritate the skin and eyes and may result in mutations. High amounts of aminophenol exposure might impair the blood's ability to carry oxygen, resulting in headaches, lethargy, dizziness and blue lips and skin (methemoglobinemia). Breathing difficulties, collapse and even death, might result in higher amounts.
Additionally, aminophenols have been linked to skin allergies. If an allergy forms, even relatively few subsequent exposures may result in skin rashes and itching. Aminophenols may also bring on a similar allergy to asthma. Future exposure may result in asthma attacks with chest tightness, wheezing, coughing and shortness of breath. Aminophenols may impact the kidneys.
Using the fixed dose method, the Scientific Committee on Consumer Products, SCCP, discovered that m-aminophenol is acutely hazardous when consumed orally. Four female rats were given 500 mg/kg of the test drug by oral gavage per the aforementioned test. For two weeks, clinical indicators and mortality were monitored. However, no deaths happened. All animals displayed piloerections, dyspnea and hypoactivity or sedation on day 1. On day 2, recovery was complete with weight gain and a macroscopic examination found no anomalies.
As a result, of the aforementioned factors, stringent regulations and scrutinization are applied to the production of aminophenol. For instance, aminophenol and aminophenol-containing products are tested and regulated under REACH Regulation (EC) No 1907/2006 and Regulation (EC) No 1223/2009 in the EU. The regulation mandate that the concentration of aminophenol should not exceed 0.9% in oxidative hair dye formulations and other similar consumer products.
Nonetheless, since the health impacts and regulations hamper the demand for aminophenols, the respective facts could be recognized as market restraints.
COVID-19 Impact Analysis
The production of Paracetamol, an analgesic and antipyretic drug is the primary and most significant use of aminophenol. It is a crucial component in synthesizing pharmaceutical ingredients and significant industrial chemicals such as Acebutolol, Ambroxol, Sorafenib and paracetamol.
Due to the COVID-19 epidemic, demand for aminophenol has exploded. Numerous attempts were made to treat affected people using already-approved drugs when the corona pandemic started to spread internationally in the spring of 2020. Paracetamol was made news because it was suggested by many countries and the World Health Organization as a strong painkiller and fever reducer that would lower COVID-19 infection symptoms like fever, body aches and headaches. Additionally, there were concerns that some drugs, such as ibuprofen, can have adverse consequences when a person has a COVID-19 infection. The demand for the API increased significantly in March and April 2020 due to the two factors mentioned above, specifically the numerous prescriptions for paracetamol and warnings against other medications. As a result, producers all around the world began producing paracetamol in significant amounts. Medicine exports from countries such as China and India to other regions have risen dramatically.
Nevertheless, the COVID-19 pandemic caused concerns for the aminophenol business during the closure of manufacturing facilities and the disruption of global supply chains. Additionally, countries that foresaw a shortage barred the export of paracetamol APIs, which significantly hindered the anticipated market expansion. Similar severe variations were seen in the pricing of aminophenol and the raw material in 2020 due to the COVID-19 pandemic. For instance, the price of the supply of aminophenol from China, as well as other necessary Key Starting Materials (KSMs) and Active Pharmaceutical Ingredients (APIs), suddenly increased. If we focus on p-aminophenol specifically, its cost jumped by 100% from the previous year. For instance, the cost of p-aminophenol imported from China was approximately US$3.5/kg the year before, but it rose to approximately US$7.5/kg the following year.
Nevertheless, despite the drawbacks above, the COVID-19 pandemic has had an unusually good overall influence on the global aminophenol business.
The global aminophenol market is classified based on type, application end-user and region.
The comparatively higher applications of p-aminophenol in various end-user verticals boost its market share in the type segment
As a common ingredient in creating hair and fabric dyes, p-aminophenol is also used to produce black-and-white images as a developing agent in photography. In 2-cycle engines, it is an anti-corrosive lubricant and a corrosion inhibitor in paints. It can also be used as a wood stain to give wood a rose-colored appearance. For the synthesis of rubber antioxidants, aminophenol is one of the essential ingredients. Additionally, p-aminophenol is the primary ingredient in manufacturing acetaminophen, an important pharmaceutical API. The demand for p-aminophenol is expected to experience a major hike due to the growing application of the respective compound in various end-user verticals.
Rapid construction expansion, as well as migration toward carbon neutrality, boost the demand and sales of aminophenol in the Asia-Pacific
The Asia-Pacific area dominates the regional market for aminophenol, which is driven by demand from downstream products, particularly paracetamol. China's aminophenol has been growing recently. As the world's largest producer of aminophenol, China recently reached a production level of 110,000 tonnes.
Additionally, the two main API producers in the world, China and India, contribute 80% of the world's paracetamol market, making Asia-Pacific the region where paracetamol is mostly sourced. The countries also have the greatest drug consumption market due to their enormous population. Half of the world's production of paracetamol, 65,400 tons, is consumed in Asia-Pacific. As a result, the Asia-Pacific aminophenol market will become extremely important and experience a significant growth spurt.
The global aminophenol market is enormous and is becoming increasingly competitive due to the presence of significant players such as Glentham Life Sciences Ltd, Wego Chemical Group, Loba Chemie, Liaoning Shixing Pharmaceutical & Chemical CO., Ltd., BHARAT CHEMICALS, Taixing Yangzi Pharm Chemical CO., LTD., Parchem, CDH Fine Chemicals, EMCO Dyetuff Pvt Ltd., SEQENS Group, Merck KGaA, among others.
Sadhana Nitro Chem Limited (SNCL)
Overview: Presently, Sadhana Nitro Chem Limited (SNCL) manufactures downstream derivatives of Nitrobenzene and other intermediates for various applications in aerospace, pharma and agro, optical brightening agents, plastic additives, special fibers, epoxy resin hardeners, dyes and performance chemicals.
SNCL provides immediate and assured service to its European clientele through its 100% subsidiary Anuchem b.v.b.a. in Antwerp, Belgium.
The global aminophenol market report would provide approximately 61 tables, 59 figures and almost 176 pages.
Product Audience 2023
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