PUBLISHER: Grand View Research | PRODUCT CODE: 1790272
PUBLISHER: Grand View Research | PRODUCT CODE: 1790272
Phosphoramidite Market Summary
The global phosphoramidite market size was estimated at USD 1.15 billion in 2024 and is projected to reach USD 2.27 billion by 2033, growing at a CAGR of 8.06% from 2025 to 2033. The market growth can be attributed to the increasing demand for phosphoramidite in the production of oligonucleotides, the rising prevalence of genetic disorders and infectious diseases has led to a surge in research and development activities in the biotechnology and pharmaceutical industries, which further fuels the demand for phosphoramidite.
Moreover, the growing geriatric population and increasing healthcare expenditure are also expected to drive the market growth in the coming years.
Rising Demand for Oligonucleotide Therapeutics
The increasing adoption of oligonucleotide-based therapeutics is a major growth driver for the phosphoramidite industry. Pharmaceutical and biotechnology companies are investing heavily in the development of antisense oligonucleotides (ASOs), small interfering RNAs (siRNA), and messenger RNA (mRNA) therapies to address a wide range of genetic, infectious, and rare diseases. These therapies rely on precisely synthesized oligonucleotides, with phosphoramidites serving as the essential chemical intermediates for constructing nucleotide chains. The success of mRNA vaccines during the COVID-19 pandemic has further validated the therapeutic potential of synthetic RNA, accelerating research and regulatory acceptance of oligo-based modalities.
ASOs and siRNAs are gaining prominence as next-generation therapeutics due to their ability to selectively silence or modulate gene expression. Multiple ASO-based drugs have already received regulatory approvals, and a robust pipeline is in development targeting neurological disorders, cancers, and metabolic conditions. As the therapeutic landscape shifts towards nucleic acid-based solutions, the demand for high-purity, modified, and scalable phosphoramidites is growing exponentially. Drug developers require consistent and high-quality oligonucleotides that meet stringent regulatory standards for safety and efficacy, thereby increasing reliance on trusted suppliers with proven synthesis capabilities.
In addition, mRNA therapeutics are being explored beyond vaccines, including applications in oncology, cardiovascular diseases, and protein replacement therapies. These advancements demand more complex and specialized phosphoramidites for coding sequences, modified caps, and regulatory elements. This trend is prompting strategic partnerships between oligo manufacturers and pharmaceutical innovators to ensure secure supply chains, technological integration, and quality assurance. With the global pipeline for nucleic acid drugs expanding and clinical trials accelerating, the phosphoramidite industry is well-positioned for long-term growth as a foundational enabler of oligonucleotide therapeutics.
Global Phosphoramidite Market Report Segmentation
This report forecasts revenue growth and provides an analysis of the latest trends in each of the sub-segments from 2021 to 2033. For this report, Grand View Research has segmented the global phosphoramidite market based on type, application, end use, and region.