PUBLISHER: Grand View Research | PRODUCT CODE: 2018403
PUBLISHER: Grand View Research | PRODUCT CODE: 2018403
The global hereditary angioedema therapeutics market size was estimated at USD 3.60 billion in 2025 and is projected to reach USD 8.18 billion by 2033, growing at a CAGR of 10.43% from 2026 to 2033. The global hereditary angioedema therapeutics market is expanding due to increasing diagnosis rates and greater clinical awareness of rare genetic disorders.
Improved access to specialized testing has enabled earlier identification of patients, which supports timely treatment initiation. The availability of targeted therapies that address underlying disease pathways has strengthened treatment outcomes and patient confidence. Pharmaceutical innovation has introduced convenient administration options, including subcutaneous and oral formulations, which improve adherence. Rising prevalence reporting across developed and emerging regions continues to create sustained demand for effective therapies.
Advancements in biologics and novel drug classes represent another major growth driver for the market. Long-acting prophylactic therapies have reduced attack frequency and improved quality of life for patients, which has increased adoption among physicians. Oral kallikrein inhibitors and gene-targeted approaches under development are expanding the future treatment landscape. Strong clinical trial activity and regulatory approvals have accelerated commercialization timelines for innovative therapies. For instance, December 2025, HCPLive reported that the U.S. Food and Drug Administration had approved three new hereditary angioedema treatments in 2025 over three months, including garadacimab gxii, Andembry, in June, sebetralstat, Ekterly, in July, and donidalorsen, Dawnzera, in August, in a disease affecting about 1 in 50,000 people globally and nearly 6,000 in the United States. Prior to these approvals, 9 therapies were available, increasing to 12 by 2026, reflecting the expansion of oral and injectable options. Strategic collaborations between biotechnology firms and larger pharmaceutical companies have further enhanced research capabilities and global distribution reach.
Healthcare infrastructure improvements and the expansion of specialty care networks are further contributing to market growth. Increased involvement of immunologists and rare disease specialists has strengthened disease management standards and treatment utilization. Patient advocacy initiatives and education programs have encouraged treatment uptake and long-term therapy compliance. Favorable reimbursement coverage in several regions has improved patient access to high-cost biologic treatments. For instance, in December 2025, Rare Disease Advisor reported that the U.S. Food and Drug Administration had approved berotralstat, marketed as ORLADEYO, as the first oral plasma kallikrein inhibitor prophylactic therapy for hereditary angioedema in children aged 2 to 11 years, extending prior approval for patients 12 years and older. The pediatric approval was based on the APeX P trial involving 29 patients aged 2 to 11 years, 48.3 percent female, with a mean age of 8 years and a mean onset at 2 years, demonstrating sustained reductions in monthly attack rates and a peak median concentration of 3.9 hours, range 0.9 to 6.0 hours. Growing investment in rare disease research continues to support innovation and competitive market expansion.
Global Hereditary Angioedema Therapeutics Market Report Segmentation
This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2021 to 2033. For this study, Grand View Research has segmented the global hereditary angioedema therapeutics market based on treatment, end use, route of administration, and region: