PUBLISHER: The Business Research Company | PRODUCT CODE: 1955432
PUBLISHER: The Business Research Company | PRODUCT CODE: 1955432
Hereditary angioedema (HAE) therapeutics refer to treatments for an autosomal dominant disorder caused by a deficiency or dysfunction of the C1-inhibitor protein. Symptoms of hereditary angioedema include angioedema affecting the upper airway, skin, and/or gastrointestinal tract.
The main drug classes of hereditary angioedema therapeutics include C1 esterase inhibitors, selective bradykinin B2 receptor antagonists, kallikrein inhibitors, and others. C1 esterase inhibitor is a protein found in the fluid component of blood that regulates the complement system protein C1. These therapeutics are administered through intravenous, subcutaneous, and oral routes and are distributed via hospital pharmacies, retail pharmacies, and other channels. Applications of hereditary angioedema therapeutics include both prophylactic treatment and on-demand management.
Tariffs have influenced the hereditary angioedema therapeutics market by increasing the cost of imported biologics and specialty drug components, particularly affecting segments like recombinant C1 esterase inhibitors and kallikrein inhibitors. Regions such as North America and Europe, which import advanced therapies, face higher production and distribution costs. While tariffs have slowed some adoption due to elevated pricing, they have also encouraged local manufacturing and innovation in cost-efficient treatment delivery solutions, creating potential opportunities for domestic players.
The hereditary angioedema therapeutics market research report is one of a series of new reports from The Business Research Company that provides hereditary angioedema therapeutics market statistics, including hereditary angioedema therapeutics industry global market size, regional shares, competitors with a hereditary angioedema therapeutics market share, detailed hereditary angioedema therapeutics market segments, market trends and opportunities, and any further data you may need to thrive in the hereditary angioedema therapeutics industry. This hereditary angioedema therapeutics market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The hereditary angioedema therapeutics market size has grown rapidly in recent years. It will grow from $7.77 billion in 2025 to $9.27 billion in 2026 at a compound annual growth rate (CAGR) of 19.3%. The growth in the historic period can be attributed to limited awareness about hae, dependency on hospital-based therapy, fewer approved therapeutic options, reliance on intravenous administration, low prevalence diagnosis rates.
The hereditary angioedema therapeutics market size is expected to see rapid growth in the next few years. It will grow to $19.03 billion in 2030 at a compound annual growth rate (CAGR) of 19.7%. The growth in the forecast period can be attributed to growth in recombinant c1 esterase inhibitors, adoption of subcutaneous delivery methods, rising prophylactic therapy usage, expansion of specialty pharmacy channels, increasing investment in rare disease research. Major trends in the forecast period include personalized therapy development, increased orphan drug approvals, advancements in subcutaneous drug delivery, development of on-demand treatment options, expansion of hospital and retail pharmacy networks.
The rising level of healthcare expenditure is anticipated to drive the expansion of the hereditary angioedema therapeutics market in the coming years. Healthcare expenditure represents the total financial and resource-based spending on healthcare goods and services within a defined period and geographic region. Higher healthcare spending enables greater investment in research and development initiatives aimed at understanding the underlying mechanisms of hereditary angioedema and advancing innovative therapeutic options. For example, in June 2025, according to the Centers for Medicare & Medicaid Services, a US-based federal agency, National Health Expenditure increased by 7.5% to $4.9 trillion in 2023, equating to $14,570 per person and accounting for 17.6% of the gross domestic product. Hospital expenditures rose by 10.4% to $1,519.7 billion in 2023, significantly outpacing the 3.2% growth recorded in 2022. As a result, increasing healthcare expenditure is supporting the growth of the hereditary angioedema therapeutics market.
Major companies operating in the hereditary angioedema therapeutics market are focusing on the development of innovative treatment options, such as oral plasma kallikrein inhibitors, to improve disease management and offer effective, on-demand solutions for controlling hereditary angioedema attacks. Oral plasma kallikrein inhibitors are orally administered drugs that block the activity of the plasma kallikrein enzyme, thereby reducing the severity and frequency of hereditary angioedema episodes. For instance, in September 2024, KalVista Pharmaceuticals, a US-based biopharmaceutical company, received acceptance from the U.S. Food and Drug Administration for a new drug application for sebetralstat. This therapy is intended to provide patients with a convenient, non-invasive alternative to intravenous or subcutaneous treatments, addressing the growing need for fast-acting oral therapies that can be administered immediately during an attack.
In February 2023, Takeda Pharmaceutical Company, a Japan-based pharmaceutical company, acquired Nimbus Lakshmi Inc. from Nimbus Therapeutics LLC for an undisclosed amount. This acquisition strengthened Takeda's late-stage development pipeline and supported the expansion of its portfolio across multiple therapeutic areas, helping to sustain long-term global growth. Nimbus Lakshmi Inc., a wholly owned subsidiary of Nimbus Therapeutics, is a US-based company developing the tyrosine kinase 2 inhibitor NDI-034858.
Major companies operating in the hereditary angioedema therapeutics market are Sanofi S.A., Pharming Healthcare Inc., Attune Pharmaceuticals Inc., BioCryst Pharmaceuticals Inc., CSL Behring LLC, KalVista Pharmaceutical Inc., Dyax Corp., Pharvaris N.V., Kedrion Biopharma Inc., Shire Pharmaceuticals, Octapharma AG, Pharmalink AB, Sobi AB, OctoPharma USA, HAE Pharma, Argenx SE, ImmunoGen Inc., Ionis Pharmaceuticals (for pipeline HAE therapies), PharmAthene Inc., BioMarin Pharmaceutical Inc.
North America was the largest region in the global hereditary angioedema therapeutics market in 2025. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the hereditary angioedema therapeutics market report are Asia-Pacific, South East Asia, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
The countries covered in the hereditary angioedema therapeutics market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Taiwan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The hereditary angioedema therapeutics market includes revenues earned by entities by diagnosis and evaluation, treatment, and management of hereditary angioedema. The market value includes the value of related goods sold by the service provider or included within the service offering. The hereditary angioedema therapeutics market also includes of sales of tranexamic acid, danazol, intravenous and subcutaneous nano-filtered purified plasma-derived human C1 esterase inhibitor concentrate, and lanadelumab. Values in this market are 'factory gate' values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Hereditary Angioedema Therapeutics Market Global Report 2026 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses hereditary angioedema therapeutics market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for hereditary angioedema therapeutics ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward, including technological disruption, regulatory shifts, and changing consumer preferences? The hereditary angioedema therapeutics market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, total addressable market (TAM), market attractiveness score (MAS), competitive landscape, market shares, company scoring matrix, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
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