mRNA Platform Market by mRNA Type, Indication, Application, End-User

List of Tables

[194 Pages Report] The mRNA Platform Market size was estimated at USD 13.52 billion in 2023 and expected to reach USD 16.33 billion in 2024, at a CAGR 21.44% to reach USD 52.71 billion by 2030.

The mRNA (messenger RNA) platform is a novel approach in the field of medicine and biotechnology, primarily utilized for the development of vaccines and therapeutics. mRNA serves as a molecular intermediary between the DNA in cells and the proteins that are essential for various bodily functions. The mRNA platform leverages synthetic mRNA to instruct cells to produce specific proteins that can trigger an immune response or stimulate cell repair without altering the cell's DNA. The ability of mRNA platforms to accelerate the development and production of vaccines and the rising global need to effectively and quickly produce vaccines has driven the need for mRNA platforms. mRNA therapies can be tailored to fight a wide array of diseases, from infectious diseases to cancer, by simply modifying the mRNA sequence the vaccines carry. This versatility opens up new avenues in personalized medicine and treatments for various conditions. However, mRNA vaccines and therapeutics require ultra-cold storage to remain stable, presenting logistical challenges in distribution, particularly in regions with limited infrastructure. Efficiently delivering mRNA into cells without degradation is a considerable hurdle. Researchers are continuously working on finding and improving lipid nanoparticles and other delivery methods to protect the mRNA until it reaches the target cells. Beyond preventive vaccines, mRNA technology is being explored for therapeutic applications, including cancer treatment, genetic disorders, and autoimmune diseases.

KEY MARKET STATISTICS
Base Year [2023]	USD 13.52 billion
Estimated Year [2024]	USD 16.33 billion
Forecast Year [2030]	USD 52.71 billion
CAGR (%)	21.44%

mRNA Type: Ability of nucleoside-modified mRNA to balance immune response efficacy with reduced side effects and offer enhanced stability

Nucleoside-modified mRNA involves the alteration of RNA building blocks (nucleosides) to evade the body's natural defenses, which might otherwise rapidly degrade the mRNA or trigger an unwanted immune response. By modifying these nucleosides, scientists can enhance the stability and translational capacity of the mRNA, making it more effective in delivering the therapeutic or vaccine message to the body's cells. This type of mRNA has been widely used in developing COVID-19 vaccines due to its efficiency in producing a strong and lasting immune response with minimal side effects. Self-amplifying mRNA, often derived from the genome of positive-strand RNA viruses, has the unique ability to replicate itself within the host cells. This amplification process means that smaller doses can be administered, potentially reducing production costs and improving accessibility. In addition to encoding the antigen of interest (such as parts of a virus against which an immune response is desired), this mRNA also encodes the viral replication machinery, enabling the prolonged production of the antigen and thereby inducing a stronger and longer-lasting immune response. Unmodified mRNA is the most straightforward form of mRNA used in medical applications. It does not undergo the nucleoside modifications seen in nucleoside-modified mRNA. While this simplifies its production, unmodified mRNA is more susceptible to degradation and may induce stronger innate immune responses, providing a potent stimulant for the immune system but also potentially leading to adverse effects.

End-User: Extensive involvement of pharmaceutical companies in the marketing and authorization of mRNA platforms

Hospitals and clinics primarily use mRNA-based treatments and vaccines as part of their patient care services. They are at the forefront of administering vaccines developed using the mRNA platform, playing a crucial role in public health initiatives, especially during pandemics. Additionally, mRNA-based therapies for certain diseases might be provided in hospital settings under specialized care. Pharmaceutical companies are instrumental in the development, testing, and commercialization of mRNA-based drugs and vaccines. They invest heavily in research and development (R&D) to explore the potential of mRNA technology in treating a wide array of diseases, beyond just infectious diseases to include cancer and genetic disorders. These companies handle the complex processes of clinical trials, regulatory approvals, and mass production of successful mRNA treatments. Thus, pharmaceutical companies are key institutions in advancing the mRNA platform and bringing new therapies from the lab to the market. Research and academic institutions conduct fundamental research to understand the mechanism of mRNA within the cell, explore innovative approaches to improve mRNA delivery and stability, and develop new applications for this technology. These institutions often collaborate with pharmaceutical companies and provide the foundational knowledge necessary for further development of mRNA-based treatments. While they are not involved in the commercialization process, their role in expanding the scientific understanding of mRNA and its potential applications is valuable.

Regional Insights

The Americas, particularly the United States and Canada, present a mature landscape for the mRNA platform, driven by the high healthcare expenditure, sophisticated healthcare infrastructure, and a strong focus on research and innovation. The Americas region is characterized by the presence of several biotechnology and pharmaceutical companies that frequently invest in R&D programs to improve the safety, efficiency, and performance of mRNA platforms. EU countries lead in regulatory frameworks supporting mRNA research and product approvals. Nations such as the U.K., Germany, and France have strong biotech sectors that are propelled by collaborative efforts between governments, academia, and private sectors. The European Medicine Agency (EMA) plays a pivotal role in facilitating the swift approval of mRNA-based treatments. APAC region is a rapidly evolving landscape for mRNA platform technologies driven by China, Japan, and India. The region's significant population base presents a vast need for vaccines and therapeutic treatments, including mRNA platforms. Government support for improving the healthcare infrastructure notably and a growing awareness of advanced treatment modalities present significant opportunities for the expansion of mRNA platforms. APAC's strategic position as a manufacturing hub for vaccines and drug therapeutics also serves to create a conducive framework for driving the adoption of mRNA platforms.

FPNV Positioning Matrix

The FPNV Positioning Matrix is pivotal in evaluating the mRNA Platform Market. It offers a comprehensive assessment of vendors, examining key metrics related to Business Strategy and Product Satisfaction. This in-depth analysis empowers users to make well-informed decisions aligned with their requirements. Based on the evaluation, the vendors are then categorized into four distinct quadrants representing varying levels of success: Forefront (F), Pathfinder (P), Niche (N), or Vital (V).

Market Share Analysis

The Market Share Analysis is a comprehensive tool that provides an insightful and in-depth examination of the current state of vendors in the mRNA Platform Market. By meticulously comparing and analyzing vendor contributions in terms of overall revenue, customer base, and other key metrics, we can offer companies a greater understanding of their performance and the challenges they face when competing for market share. Additionally, this analysis provides valuable insights into the competitive nature of the sector, including factors such as accumulation, fragmentation dominance, and amalgamation traits observed over the base year period studied. With this expanded level of detail, vendors can make more informed decisions and devise effective strategies to gain a competitive edge in the market.

Key Company Profiles

The report delves into recent significant developments in the mRNA Platform Market, highlighting leading vendors and their innovative profiles. These include Accanis Biotech F&E GmbH & Co KG, Aldevron, LLC by Danaher Corporation, Arcturus Therapeutics, Inc., Argos Therapeutics, Inc., AstraZeneca plc, Avectas Limited, BioNTech SE, Catalent, Inc., CRISPR Therapeutics AG, CureVac N.V., Daiichi Sankyo, Dicerna Pharmaceuticals, Inc by Novo Nordisk A/S, eTheRNA, ethris GmbH, Gritstone bio, In-Cell-Art, Merck & Co., Inc., Moderna, Inc., Pfizer Inc., Precision BioSciences, Inc., Regulus Therapeutics Inc., Sangamo Therapeutics, Inc., Sanofi S.A., Tiba Biotech LLC, and Verve Therapeutics.

Market Segmentation & Coverage

This research report categorizes the mRNA Platform Market to forecast the revenues and analyze trends in each of the following sub-markets:

mRNA Type
- Nucleoside-Modified mRNA
- Self-Amplifying mRNA
- Unmodified mRNA

Indication
- Autoimmune Diseases
- Cancer
  - Personalized Treatment
  - Single Cancer Focussed

Infectious Diseases
Rare Diseases
Respiratory Diseases

Application
- Therapeutics
- Vaccines

End-User
- Hospitals & Clinics
- Pharmaceutical Companies
- Research & Academic Institutiions

Region
- Americas
  - Argentina
  - Brazil
  - Canada
  - Mexico
  - United States
    - California
    - Florida
    - Illinois
    - New York
    - Ohio
    - Pennsylvania
    - Texas
- Asia-Pacific
  - Australia
  - China
  - India
  - Indonesia
  - Japan
  - Malaysia
  - Philippines
  - Singapore
  - South Korea
  - Taiwan
  - Thailand
  - Vietnam

Europe, Middle East & Africa
- Denmark
- Egypt
- Finland
- France
- Germany
- Israel
- Italy
- Netherlands
- Nigeria
- Norway
- Poland
- Qatar
- Russia
- Saudi Arabia
- South Africa
- Spain
- Sweden
- Switzerland
- Turkey
- United Arab Emirates
- United Kingdom

The report offers valuable insights on the following aspects:

1. Market Penetration: It presents comprehensive information on the market provided by key players.

2. Market Development: It delves deep into lucrative emerging markets and analyzes the penetration across mature market segments.

3. Market Diversification: It provides detailed information on new product launches, untapped geographic regions, recent developments, and investments.

4. Competitive Assessment & Intelligence: It conducts an exhaustive assessment of market shares, strategies, products, certifications, regulatory approvals, patent landscape, and manufacturing capabilities of the leading players.

5. Product Development & Innovation: It offers intelligent insights on future technologies, R&D activities, and breakthrough product developments.

The report addresses key questions such as:

1. What is the market size and forecast of the mRNA Platform Market?

2. Which products, segments, applications, and areas should one consider investing in over the forecast period in the mRNA Platform Market?

3. What are the technology trends and regulatory frameworks in the mRNA Platform Market?

4. What is the market share of the leading vendors in the mRNA Platform Market?

5. Which modes and strategic moves are suitable for entering the mRNA Platform Market?

Product Code: MRR-374DB5A05ED7

1. Preface

1.1. Objectives of the Study
1.2. Market Segmentation & Coverage
1.3. Years Considered for the Study
1.4. Currency & Pricing
1.5. Language
1.6. Stakeholders

2. Research Methodology

2.1. Define: Research Objective
2.2. Determine: Research Design
2.3. Prepare: Research Instrument
2.4. Collect: Data Source
2.5. Analyze: Data Interpretation
2.6. Formulate: Data Verification
2.7. Publish: Research Report
2.8. Repeat: Report Update

3. Executive Summary

4. Market Overview

5. Market Insights

5.1. Market Dynamics
- 5.1.1. Drivers
  - 5.1.1.1. Surge in demand of therapies and vaccines due to the infectious diseases
  - 5.1.1.2. Need to reduce vaccine development and commercialization timeline
- 5.1.2. Restraints
  - 5.1.2.1. Complexity in optimising manufacturing and commercial pathways
- 5.1.3. Opportunities
  - 5.1.3.1. Increased market capitalization and public funding
  - 5.1.3.2. mRNA technology optimization on development of on-demand vaccines
- 5.1.4. Challenges
  - 5.1.4.1. High regulatory risk and hurdles in supply logistics
5.2. Market Segmentation Analysis
- 5.2.1. mRNA Type: Ability of nucleoside-modified mRNA to balance immune response efficacy with reduced side effects and offer enhanced stability
- 5.2.2. End-User: Extensive involvement of pharmaceutical companies in the marketing and authorization of mRNA platforms
5.3. Market Disruption Analysis
5.4. Porter's Five Forces Analysis
- 5.4.1. Threat of New Entrants
- 5.4.2. Threat of Substitutes
- 5.4.3. Bargaining Power of Customers
- 5.4.4. Bargaining Power of Suppliers
- 5.4.5. Industry Rivalry
5.5. Value Chain & Critical Path Analysis
5.6. Pricing Analysis
5.7. Technology Analysis
5.8. Patent Analysis
5.9. Trade Analysis
5.10. Regulatory Framework Analysis

6. mRNA Platform Market, by mRNA Type

6.1. Introduction
6.2. Nucleoside-Modified mRNA
6.3. Self-Amplifying mRNA
6.4. Unmodified mRNA

7. mRNA Platform Market, by Indication

7.1. Introduction
7.2. Autoimmune Diseases
7.3. Cancer
7.4. Infectious Diseases
7.5. Rare Diseases
7.6. Respiratory Diseases

8. mRNA Platform Market, by Application

8.1. Introduction
8.2. Therapeutics
8.3. Vaccines

9. mRNA Platform Market, by End-User

9.1. Introduction
9.2. Hospitals & Clinics
9.3. Pharmaceutical Companies
9.4. Research & Academic Institutiions

10. Americas mRNA Platform Market

10.1. Introduction
10.2. Argentina
10.3. Brazil
10.4. Canada
10.5. Mexico
10.6. United States

11. Asia-Pacific mRNA Platform Market

11.1. Introduction
11.2. Australia
11.3. China
11.4. India
11.5. Indonesia
11.6. Japan
11.7. Malaysia
11.8. Philippines
11.9. Singapore
11.10. South Korea
11.11. Taiwan
11.12. Thailand
11.13. Vietnam

12. Europe, Middle East & Africa mRNA Platform Market

12.1. Introduction
12.2. Denmark
12.3. Egypt
12.4. Finland
12.5. France
12.6. Germany
12.7. Israel
12.8. Italy
12.9. Netherlands
12.10. Nigeria
12.11. Norway
12.12. Poland
12.13. Qatar
12.14. Russia
12.15. Saudi Arabia
12.16. South Africa
12.17. Spain
12.18. Sweden
12.19. Switzerland
12.20. Turkey
12.21. United Arab Emirates
12.22. United Kingdom

13. Competitive Landscape

13.1. Market Share Analysis, 2023
13.2. FPNV Positioning Matrix, 2023
13.3. Competitive Scenario Analysis
- 13.3.1. VBI Vaccines Inc.'s Groundbreaking Advancement in mRNA Vaccine Technology with Government of Canada Support
- 13.3.2. Elevating the Future of Healthcare: The Pioneering Alliance for mRNA Medicines
- 13.3.3. Sensible Biotechnologies and Ginkgo Bioworks Forge Strategic Alliance for Revolutionizing mRNA Production
13.4. Strategy Analysis & Recommendation

14. Competitive Portfolio

14.1. Key Company Profiles
14.2. Key Product Portfolio