PUBLISHER: MarketsandMarkets | PRODUCT CODE: 1877351
PUBLISHER: MarketsandMarkets | PRODUCT CODE: 1877351
The PDX model market is expected to reach USD 0.66 billion in 2030 from USD 0.37 billion in 2025, at a CAGR of 12.5% during the forecast period. The market is primarily driven by the increasing incidence of cancer and the growing demand for effective preclinical models that closely replicate human tumor biology. The increasing use of patient-derived xenograft (PDX) models in oncology research to evaluate drug efficacy, discover biomarkers, and inform personalized treatment approaches further supports market growth. Additionally, advancements in immunodeficient mouse models and the integration of PDX platforms with next-generation sequencing technologies are enhancing their translational value.
| Scope of the Report | |
|---|---|
| Years Considered for the Study | 2023-2030 |
| Base Year | 2024 |
| Forecast Period | 2025-2030 |
| Units Considered | Value (USD billion) |
| Segments | Implantation Method, Type, Tumor Type, Applications, End User |
| Regions covered | North America, Europe, the Asia Pacific, Latin America, the Middle East, and Africa |
However, the high cost and time-intensive nature of PDX model development, along with ethical considerations and variability in model reproducibility, continue to restrain widespread market adoption.

"Orthotopic implantation segment is expected to grow at the highest CAGR during the forecast period"
The orthotopic implantation segment is expected to grow at the highest CAGR in the patient-derived xenograft (PDX) model market owing to its superior ability to mimic the natural tumor environment and disease progression seen in human cancers. This technique allows tumor cells to be implanted at their original tissue site, enabling a more accurate representation of tumor-stroma interactions, angiogenesis, and metastatic spread. As a result, orthotopic models provide higher translational relevance and predictive accuracy for assessing drug efficacy and resistance mechanisms compared to other model types. The increasing adoption of targeted therapies and immunotherapies has further fueled the demand for orthotopic models, as they provide a more physiologically relevant context for evaluating therapeutic responses. Additionally, advancements in imaging modalities and microsurgical techniques have improved the reproducibility and monitoring of orthotopic PDX studies, making them more accessible and reliable for preclinical research. These advantages collectively drive the rapid growth of the orthotopic implantation segment in the global PDX model market.
"Gastrointestinal tumor model segment holds the largest share of the market"
The gastrointestinal (GI) tumor model segment holds the largest share of the patient-derived xenograft (PDX) model market, driven by the high global incidence of gastrointestinal malignancies, including colorectal, gastric, pancreatic, and liver cancers. These cancers are among the leading causes of cancer-related mortality, creating a strong demand for reliable preclinical models that accurately replicate tumor heterogeneity and progression. Gastrointestinal PDX models closely preserve the histological and genetic characteristics of patient tumors, enabling more predictive evaluation of therapeutic efficacy and resistance mechanisms. Their robust application in assessing targeted therapies, immunotherapies, and combination treatment strategies has made them a cornerstone of translational oncology research. Furthermore, the growing emphasis on precision medicine and the rising volume of clinical trials focused on GI cancers have accelerated the adoption of these models. Continuous advancements in engraftment techniques and molecular profiling further enhance the utility of gastrointestinal PDX models, solidifying their leading position in the global market.
"The US is expected to grow at the highest CAGR during the forecast period"
The US is expected to register the highest growth rate in the patient-derived xenograft (PDX) model market during the forecast period. This growth is primarily driven by the strong presence of leading pharmaceutical and biotechnology companies, well-established research infrastructure, and extensive oncology research initiatives. The rising prevalence of cancer, coupled with increasing adoption of personalized medicine and targeted therapy development, is significantly boosting the demand for PDX models. Furthermore, growing investment in translational and preclinical cancer research, along with strong collaborations between academic institutions and industry players, is accelerating market expansion.
Additionally, the availability of advanced laboratory facilities, the presence of comprehensive biobanking systems, and supportive government funding for cancer drug discovery further strengthen the country's position in the global market. The US regulatory environment also promotes innovation while ensuring the reliability and ethical compliance of PDX-based studies. These factors collectively contribute to the rapid adoption of PDX models, reinforcing North America's leadership in the global market.
JSR Corporation (Japan), WuXi AppTec (China), The Jackson Laboratory (US), Charles River Laboratories (US), Taconic Biosciences, Inc. (US), Oncodesign Precision Medicine (France), Inotiv (US), Pharmatest Services (Finland), Hera Biolabs (US), EPO Berlin-Buch GmbH (Germany), XenTech (France), Urosphere (France), Altogen Labs (US), Abnova Corporation (Taiwan), Genesis Biotechnology Group (US), Biocytogen Pharmaceuticals (Beijing) Co., Ltd. (China), Creative Animodel (US), BioDuro (US), Aragen Life Sciences (India), LIDE Shanghai Biotech, Ltd (China), Certis Oncology Solutions (US), InnoSer (Netherlands), IVRS AB (Sweden), Beijing IDMO Co., Ltd. (China), and Shanghai ChemPartner (China) are some of the key companies offering PDX models.
Research Coverage
This research report categorizes the PDX model market by implantation method (subcutaneous implantation, orthotopic implantation, others), type (mouse model, rat model), tumor type (gastrointestinal, gynecological, respiratory, urological, hematological, other tumor models), application (preclinical drug development, biomarker analysis, translational research, biobanks), end user (pharmaceutical & biotechnology companies, contract research organizations (CROs), academic & research institutes), and region (North America, Europe, Asia Pacific, Latin America, Middle East, And Africa).
The report's scope encompasses detailed information about the primary factors, including drivers, restraints, challenges, and opportunities, that influence the growth of the PDX model market. A comprehensive analysis of key industry players has been performed to provide insights into their business overview, product portfolio, key strategies, new product launches, acquisitions, and recent developments related to the PDX model market. This report also includes a competitive analysis of emerging startups in the PDX model industry ecosystem.
Key Benefits of Buying the Report
The report will assist market leaders and new entrants by providing revenue estimates for the overall market and its subsegments. It will also help stakeholders better understand the competitive landscape and gain more insights to position their businesses effectively and develop suitable go-to-market strategies. This report will enable stakeholders to grasp the market's pulse and offer information on key market drivers, restraints, opportunities, and challenges.