PUBLISHER: MarketsandMarkets | PRODUCT CODE: 2130448
PUBLISHER: MarketsandMarkets | PRODUCT CODE: 2130448
The oligonucleotide CDMO market is expected to reach USD 11.14 billion in 2031, up from USD 3.88 billion in 2026, at a CAGR of 23.5% over the forecast period. The oligonucleotide CDMO market is expanding as pharmaceutical and biotechnology companies increasingly outsource development and manufacturing to support growing oligonucleotide pipelines. Growing CDMO partnerships to enable scalability are driving demand for process development, synthesis, purification, analytical testing, and GMP manufacturing as programs advance toward clinical and commercial stages. Sponsors are increasingly seeking CDMOs with flexible capacity and integrated capabilities to support development through commercial manufacturing.
| Scope of the Report | |
|---|---|
| Years Considered for the Study | 2026-2031 |
| Base Year | 2025 |
| Forecast Period | 2026-2031 |
| Units Considered | Value (USD billion) |
| Segments | Service Type, Type, Application, and End User |
| Regions covered | North America, Europe, the Asia Pacific, Latin America, the Middle East, and Africa |
However, the complexities of therapeutic oligonucleotide manufacturing remain a key restraint. Longer sequences, chemical modifications, and conjugation can increase synthesis and purification challenges. Maintaining consistent quality during scale-up also requires specialized equipment, validated processes, and skilled personnel. Consequently, CDMOs with scalable infrastructure and strong analytical capabilities are better positioned to support complex oligonucleotide programs.

"Antisense oligonucleotides segment is expected to grow at the highest CAGR during the forecast period"
The antisense oligonucleotide (ASO) segment is projected to grow at the highest CAGR in the oligonucleotide CDMO market, driven by expanding development of ASO-based therapeutics and increased outsourcing of manufacturing. ASO programs require specialized synthesis, purification, analytical testing, and GMP manufacturing capabilities. The advancement of ASO candidates through clinical development is increasing demand for scalable and reliable CDMO services. Rising molecular complexity is also prompting pharmaceutical and biotechnology companies to outsource manufacturing to specialized providers. These factors are expected to strengthen demand for oligonucleotide CDMO services supporting ASO development over the forecast period.
"Therapeutic applications segment to grow fastest"
The therapeutic applications segment is projected to grow at the highest CAGR in the oligonucleotide CDMO market, driven by expanding development of oligonucleotide-based therapeutics and increased outsourcing of manufacturing. Therapeutic programs require specialized services for synthesis, purification, analytical testing, and GMP manufacturing. The advancement of ASO, siRNA, and other oligonucleotide candidates through clinical development is increasing demand for scalable, regulatory-compliant manufacturing. Rising molecular complexity is further encouraging pharmaceutical and biotechnology companies to rely on specialized CDMOs. These factors are expected to strengthen demand for CDMO services supporting therapeutic applications during the forecast period.
"US is expected to grow at the highest CAGR during the forecast period"
The US is expected to post the highest CAGR in the oligonucleotide CDMO market, driven by a strong concentration of pharmaceutical and biotechnology companies with active oligonucleotide development pipelines. Established CDMO infrastructure and specialized capabilities in oligonucleotide synthesis, purification, analytical testing, and GMP manufacturing further support market growth. Rising demand for clinical and commercial manufacturing capacity is also strengthening outsourcing activity. Advancements in ASO, siRNA, and other oligonucleotide programs are driving demand for scalable manufacturing and specialized process development. These factors are expected to support continued expansion of the US oligonucleotide CDMO market over the forecast period.
Bachem (Switzerland), Thermo Fisher Scientific Inc. (US), Agilent Technologies, Inc. (US), WuXi AppTec (China), Maravai LifeSciences (US), Lonza (Switzerland), Eurofins Scientific (Luxembourg), Danaher Corporation (US), GenScript (US), Syngene International Limited (India), Ajinomoto Co., Inc. (Japan), EUROAPI (France), ST Pharm (South Korea), Kaneka Corporation (Japan), PolyPeptide Group (Switzerland), Aurigene Pharmaceutical Services Ltd. (India), BioSpring (Germany), Nippon Shokubai Co., Ltd. (Japan), LGC Biosearch Technologies (UK), Oligo Factory (US), Corden Pharma (Switzerland), Bio-Synthesis, Inc. (US), Microsynth (Switzerland), Synoligo Biotechnologies, Inc. (US), Hongene Biotech Corporation (China), Sylentis, S.A. (Spain), Creative Biogene (US), Nitto Avecia (US), and NJ Bio, Inc. (US) are key companies providing oligonucleotide CDMO services.
Research Coverage
This research report categorizes the oligonucleotide CDMO market by service type (contract manufacturing {commercial stage, clinical stage}, contract development, and other services {analytical testing, analytical method development & validation, and standalone fill-finish services}), by type (antisense oligonucleotides, small interfering RNA, and other oligonucleotides), by application (therapeutic applications, research applications, and diagnostic applications), by end user (pharmaceutical & biotechnology companies, diagnostic companies, and other end users), and by region (North America, Europe, Asia Pacific, Latin America, Middle East, and Africa).
The report's scope encompasses detailed information on the primary factors, including drivers, restraints, challenges, and opportunities, that influence the growth of the oligonucleotide CDMO market. A comprehensive analysis of key industry players has been conducted to provide insights into their business overviews, service portfolios, key strategies, service expansions, acquisitions, and recent developments related to the oligonucleotide CDMO market. This report also includes a competitive analysis of emerging startups in the oligonucleotide CDMO industry ecosystem.
Key Benefits of Buying the Report
The report will assist market leaders and new entrants by providing revenue estimates for the overall market and its subsegments. It will also help stakeholders better understand the competitive landscape and gain insights to position their businesses effectively and develop suitable go-to-market strategies. This report will enable stakeholders to grasp the market's pulse and provide information on key market drivers, restraints, opportunities, and challenges.
Competitive Assessment: In-depth assessment of market shares, growth strategies, and services of leading players, Bachem (Switzerland), Thermo Fisher Scientific Inc. (US), Agilent Technologies, Inc. (US), WuXi AppTec (China), and ST Pharm (South Korea), among others, for the oligonucleotide CDMO market.