PUBLISHER: MarketsandMarkets | PRODUCT CODE: 2158067
PUBLISHER: MarketsandMarkets | PRODUCT CODE: 2158067
The plasma fractionation market is expected to reach USD 52.58 billion in 2031, up from USD 36.44 billion in 2026, at a CAGR of 7.6% over the forecast period. The market is primarily driven by rising demand for immunoglobulins across immunology and neurology, strategic expansion of plasma collection capacity by market players, and greater use of plasma-derived therapies. Immunoglobulins, including IVIG and SCIG, are widely used to manage primary immunodeficiencies, autoimmune disorders, and neurological conditions, supporting sustained demand for plasma-derived products. In addition, companies are expanding plasma collection networks and investing in fractionation and manufacturing facilities to secure the source-plasma supply and increase production capacity.
| Scope of the Report | |
|---|---|
| Years Considered for the Study | 2026-2031 |
| Base Year | 2025 |
| Forecast Period | 2026-2031 |
| Units Considered | Value (USD billion) |
| Segments | Product, Therapeutic Area, Application, and End User |
| Regions covered | North America, Europe, Asia Pacific, Latin America, the Middle East, and Africa |
Advances in plasma collection, fractionation, chromatography, and downstream purification are improving plasma utilization and the recovery of therapeutic proteins, including immunoglobulins, albumin, and coagulation factors. However, market growth remains constrained by high treatment costs and reimbursement constraints for plasma-derived products, particularly for long-term therapies requiring repeated administration. Differences in healthcare coverage, reimbursement policies, and patient affordability across countries can limit access to plasma-derived therapies, affecting adoption and creating challenges for market expansion while maintaining product quality, safety, and supply continuity.

"Immunoglobulins segment holds the largest share of the market"
The immunoglobulins segment accounts for the largest share of the plasma fractionation market, driven by the increasing use of IVIG, SCIG, and other immunoglobulins to manage primary immunodeficiencies, autoimmune disorders, and neurological conditions. Immunoglobulins play a critical role in immunology and neurology, and recurring treatment needs support sustained demand for plasma-derived products. The growing prevalence of immune-mediated diseases, rising clinical adoption of immunoglobulin therapies, and continued investments in plasma collection and fractionation capacity are expected to further strengthen this segment's position.
"Therapeutics segment holds the largest share of the market"
The therapeutics segment accounts for the largest share of the plasma fractionation market, driven by the widespread clinical use of plasma-derived medicinal products across immunology, neurology, hematology, critical care, and pulmonology. Therapeutic applications are critical to treating immunodeficiencies, autoimmune and neurological disorders, bleeding disorders, and other conditions requiring plasma-derived therapies. Growing demand for immunoglobulins, coagulation factor concentrates, albumin, and protease inhibitors, along with rising healthcare utilization and investments in plasma-derived product manufacturing, continues to strengthen this segment's position.
"US is expected to grow at the highest CAGR during the forecast period"
The US is expected to post the highest CAGR in the plasma fractionation market, driven by a strong plasma collection infrastructure, an established presence of leading plasma fractionation companies, and high utilization of plasma-derived therapies. Rising demand for immunoglobulins, coagulation factor concentrates, albumin, and other plasma-derived products across therapeutic applications is supporting market growth. Growing investments in plasma collection capacity, fractionation and manufacturing facilities, and domestic supply capabilities are further strengthening the market. In addition, increasing adoption of advanced fractionation, purification, and high-concentration immunoglobulin formulations is expected to support demand across hospitals, specialty clinics, home care settings, and infusion centers.
CSL (Australia), Takeda Pharmaceutical Company Limited (Japan), Grifols, S.A. (Spain), Octapharma AG (Switzerland), Kedrion S.p.A. (Italy), LFB (France), ADMA Biologics, Inc. (USA), Sanquin (Netherlands), Taibang Biological Group Co., Ltd. (China), GC Biopharma Corporate (South Korea), Hualan Bioengineering Inc. (China), Japan Blood Products Organization (Japan), Emergent (US), Shanghai RAAS Blood Products Co., Ltd. (China), and Intas Pharmaceuticals Ltd. (India) are among the key companies offering plasma fractionation products.
Research Coverage
This research report categorizes the plasma fractionation market by product (Immunoglobulins [IVIG, SCIG, and other Immunoglobulins], Coagulation factor concentrates [Factor VIII, Factor IX, Von Willebrand Factor, Prothrombin complex concentrates, Factor XIII, and other coagulation factor concentrates], albumin, protease inhibitors, and other plasma products), application (therapeutics and academics & preclinical research), therapeutic area (neurology, immunology, hematology, critical care, pulmonology, hemato-oncology, rheumatology, and other applications), end user (hospitals & specialty clinics, homecare settings & infusion centers, and other end users), and region (North America, Europe, Asia Pacific, Latin America, and Middle East & Africa).
The report's scope encompasses detailed information on the primary factors, including drivers, restraints, challenges, and opportunities, that influence the growth of the plasma fractionation market. A comprehensive analysis of key industry players has been conducted to provide insights into their business overviews, product portfolios, key strategies, new product launches, acquisitions, and recent developments related to the plasma fractionation market. This report also includes a competitive analysis of emerging startups in the plasma fractionation industry ecosystem.
Key Benefits of Buying the Report
The report will assist market leaders and new entrants by providing revenue estimates for the overall market and its subsegments. It will also help stakeholders better understand the competitive landscape and gain insights to position their businesses effectively and develop suitable go-to-market strategies. This report will enable stakeholders to grasp the market's pulse and provide information on key market drivers, restraints, opportunities, and challenges.
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