South America Glucagon-like Peptide-1 (GLP-1) Agonists - Market Share Analysis, Industry Trends & Statistics, Growth Forecasts (2026 - 2031)

According to Mordor Intelligence, the South America glucagon-like peptide-1 (GLP-1) agonists market is projected to expand from USD 1.62 billion in 2025 and USD 1.73 billion in 2026 to USD 2.58 billion by 2031, registering a CAGR of 8.34% between 2026 and 2031.

South America Glucagon-like Peptide-1 (GLP-1) Agonists Market Trends and Insights

Rising Type 2 Diabetes and Obesity Treatment Demand

Diabetes and obesity create the basic demand base for the South American GLP-1 agonists market. The IDF projects diabetes cases in South and Central America will reach 52 million by 2050. This projection represents a 46% increase from the 2024 level. Regional diabetes expenditure reached USD 81 billion in 2024. That amount represented 8% of global diabetes expenditure.

The clinical role of these medicines also extends beyond glucose control. A 2025 SELECT analysis reported a 20% reduction in major adverse cardiovascular events with semaglutide. The study covered patients with obesity and established cardiovascular disease. The South American GLP-1 agonists market, therefore, has a broader clinical base than diabetes treatment alone. Treatment adoption will still depend on physician capacity and payer coverage.

Expansion of Specialist-Led Weight-Management Prescribing

Specialist prescribing is making obesity care more structured in major South American cities. Endocrinologists and obesity specialists can identify patients who need long-term therapy. They can also monitor treatment response and side effects. This care model supports continued use rather than intermittent purchases. It is especially relevant where medicines are largely paid for privately. The South American GLP-1 agonists market benefits when care pathways combine diagnosis, prescription, and follow-up.

Continuous glucose monitoring can support this approach for patients with diabetes. It gives clinicians more information when they adjust treatment plans. Novo Nordisk announced a Brazilian public-system pilot involving 1,000 patients at 3 health units in 2026. Future evaluation of public treatment models could affect the accessible patient population. The South American GLP-1 agonists market will remain tied to the availability of qualified prescribers and covered treatment pathways.

High Out-of-Pocket Treatment Cost

Out-of-pocket costs remain a major obstacle across the South American GLP-1 agonists market. Branded tirzepatide and high-dose semaglutide can exceed the budgets of many middle-income households. Cost pressure can lead patients to delay treatment or discontinue it. Lower-priced semaglutide can help in Brazil, but availability will differ across countries.

ANVISA cited manufacturing noncompliance and illegal sales without prescriptions. This intervention highlights the relationship between affordability and product safety. Patients need consistent access to regulated products. Countries without near-term semaglutide competition may face stronger affordability constraints. The South American GLP-1 agonists market will need both lower prices and reliable pharmacy oversight.

Other drivers and restraints analyzed in the detailed report include:

1. Increasing Availability of Weekly Injectable Pens
2. Local Manufacturing and Post-Patent Competition
3. Restricted Reimbursement and Uneven Public-Sector Access

For complete list of drivers and restraints, kindly check the Table Of Contents.

Segment Analysis

Semaglutide held 51.35% of the South American GLP-1 agonists market share in 2025. Its position reflected established use through Ozempic for Type-2 Diabetes and Wegovy for obesity. The molecule has a long prescribing history across the region. Brazilian competition increased after the semaglutide patent expiry in March 2026. ANVISA approved Ozivy as the first synthetic semaglutide pen in May 2026. This approval introduced a regulated domestic alternative. More product options can increase use among price-sensitive patients.

Tirzepatide is forecast to expand at a 9.22% CAGR through 2031. Its dual GLP-1 and GIP mechanism supports its differentiated clinical position. Tirzepatide remains insulated from the Brazilian semaglutide price cycle. Liraglutide, dulaglutide, and exenatide retain roles in legacy prescribing and cost-focused procurement. Dulaglutide retains value through its auto-injector format. The other category can broaden as approved products enter the South American GLP-1 agonists market.

Injectable pens accounted for 87.42% of the South American GLP-1 agonists market size in 2025. They had the largest clinical evidence base and commercial availability. Injectable products also fit established pharmacy storage and dispensing practices. Weekly dosing supports ongoing treatment for patients who accept self-injection. However, device access can be difficult in remote locations. Cold-chain conditions can also limit distribution outside major cities.

Oral tablets are expected to grow at an 8.74% CAGR through 2031. Eli Lilly reported successful results from a third Phase 3 trial for orforglipron in August 2025. Oral products could appeal to patients who do not want injections. They could also reduce dependence on specialized device logistics. Regulatory approval is still required before these products affect regional sales. The South American GLP-1 agonists market could gain a broader delivery mix after approvals.

Complete Report Scope:

• By Molecule
  • Exenatide
  • Liraglutide
  • Dulaglutide
  • Lixisenatide
  • Semaglutide
  • Tirzepatide
  • Others
• By Route of Administration
  • Injectable Pens
  • Oral Tablets
• By Indication
  • Type-2 Diabetes
  • Obesity / Weight Management
  • Cardiovascular Risk Reduction
  • Other Emerging Indications
• By Distribution Channel
  • Hospital Pharmacies
  • Retail Pharmacies
  • Online Pharmacies
  • Other Distribution Channels
• By Country
  • Brazil
  • Argentina
  • Colombia
  • Chile
  • Peru
  • Rest of South America

List of Companies Covered in this Report:

1. Adalvo
2. Amgen
3. AstraZeneca
4. Biocon
5. Biomm S.A.
6. Boehringer Ingelheim
7. Bristol-Myers Squibb
8. Eli Lilly and Company
9. EMS
10. Eurofarma Laboratorios S.A.
11. Glenmark Pharmaceuticals
12. Hypera S.A.
13. Novo Nordisk
14. Pfizer
15. Sandoz Group
16. Sanofi
17. Sun Pharmaceuticals Industries
18. Takeda Pharmaceuticals
19. Teva Pharmaceutical Industries
20. Torrent Pharmaceuticals

Additional Benefits:

• The market estimate (ME) sheet in Excel format
• 3 months of analyst support