PUBLISHER: Orion Market Research | PRODUCT CODE: 1826601
PUBLISHER: Orion Market Research | PRODUCT CODE: 1826601
CRISPR Market Size, Share & Trends Analysis Report by Application (Cell Line Engineering, CRISPR Plasmid, Gene Database/Gene Library, Genetic Engineering, Genetically Modified Organisms or Crops, Genome Editing, Human Stem Cells), and by End-User (Academic Institutes, Biotechnology Companies, Pharmaceuticals Companies, and Research and Development Institutes), Forecast Period (2025-2035)
Industry Overview
CRISPR market size, valued at $2,650 million in 2024, is projected to grow to $8,890 million by 2035, registering a CAGR of 11.6% during 2025-2035. The CRISPR market growth is driven by increasing government and private funding, as well as rising demand for CRISPR, coupled with advancements in technology. CRISPR has wide applications in genome engineering, RNA editing, Gene drive, Gene function, in vitro genetic depletion, biomedicine, disease models, and many more.
Market Dynamics
Rising Genetic Disorders are Increasing the Demand for CRISPR Technology
The demand for CRISPR is driven by increasing genetic disorders and rare diseases around the globe. According to the World Health Organization (WHO), a rare disease affects 1 in every 2,000 individuals in the general population. Recently, there have been more than 7,000 known rare diseases impacting over 300 million people globally. While 70% of these conditions begin in childhood. Additionally, there are limited resources for research and diagnosis, as well as insufficient investment and financial incentives for drug development in the area of rare diseases. As a result, more than 95% of rare diseases still lack effective treatment, which further supports the development of CRISPR-based therapies.
Limitations of CRISPR/Cas9 technology and future promise
CRISPR technology, along with innovations such as base editing and prime editing techniques, are facing traditional challenges, including off-target effects (gRNA may bind to non-target genomic sites, can initiate unintended mutations), host immune responses (as endogenous bacterial Cas9 proteins can trigger immune-mediated degradation in human cells), and ethical and regulatory challenges (with 70 countries having established clear policies against CRISPR). These limitations are increasing CRISPR's therapeutic potential and making it more accessible to researchers and clinicians globally. Additionally, the integration of artificial intelligence with CRISPR technology is further enhancing the precision and efficiency of gene editing.
Market Segmentation
The major biomedical applications of the CRISPR technology include drug discovery, gene therapy, and diagnostics. The increase in clinical trials of gene therapy across the globe is one of the major factors driving market growth. CRISPR technology in drug discovery is used for developing more physiologically relevant models, such as cell line models that correlate with clinical settings. This improvement can lead to a reduction in the failure rates of drug candidates during the initial testing phases. For Instance, in August 2023, 90% of the soybean plants are genetically modified through molecular breeding techniques, specifically using CRISPR/Cas9 gene editing technology. This technology is applied to modify functional soybean genes, enabling regulation of traits such as oil content, flowering based on photoperiod, seed coat color, seed size, plant height, and nodulation.
For example, 90% of soybean plants are genetically modified through molecular breeding techniques, specifically using CRISPR/Cas9 gene editing technology. This technology is applied to modify functional soybean genes, enabling regulation of traits such as oil content, flowering based on photoperiod, seed coat color, seed size, plant height, and nodulation.
The global CRISPR market is further divided by region, including North America (the US and Canada), Europe (the UK, Germany, France, Italy, Spain, Russia, and the Rest of Europe), Asia-Pacific (India, China, Japan, South Korea, Australia and New Zealand, ASEAN Countries, and the Rest of Asia-Pacific), and the Rest of the World (the Middle East & Africa, and Latin America).
North America Dominates the CRISPR Market
North America holds the largest market share of the global CRISPR market. The region continues to dominate the growing CRISPR ecosystem due to strong research infrastructure, favorable regulatory environments, large government investment, and major biotechnology and pharmaceutical companies. For instance, in 2019, the National Institutes of Health (NIH) awarded 24 new grants to researchers in the U.S. and Canada through the Somatic Cell Genome Editing (SCGE) program. These awards amount to approximately $89 million over four years, with these 24 new projects bringing the total number of supported projects to 45 and total funding to approximately $190 million over six years, pending available funds.
The global CRISPR market is highly competitive with a significant number of global and regional vendors. Beam Therapeutics Inc., CRISPR Therapeutics AG, Editas Medicine, Inc., Genscript Biotech Corp., and Intellia Therapeutics Inc. Additionally, the strategic partnership between market players also contributes to market growth. For instance, in December 2017, CRISPR Therapeutics and Vertex Pharmaceuticals collaborated on the CTX00, which is the first CRISPR/Cas9-based treatment for B-thalassemia and sickle cell disease.
Recent Developments