VECTOR PURIFICATION MARKET: OVERVIEW
As per Roots Analysis, the global vector purification market valued at USD 155 million in the current year is anticipated to grow at a lucrative CAGR of 21% during the forecast period.
The market sizing and opportunity analysis has been segmented across the following parameters:
Type of Viral Vector
- AAV
- Adenovirus
- Lentivirus
- Retrovirus
- Others
Type of Purification Technique
- Chromatography
- Centrifugation
- Filtration
Type of Therapy
- Gene Therapy
- Cell Therapy
- Viral Vaccines
Therapeutic Area
- Oncological Disorders
- Cardiovascular Disorders
- Ophthalmic Disorders
- Metabolic Disorders
- Inflammation & Immunological Diseases
- Others
Scale of Operation
- Preclinical / Clinical
- Commercial
Key Geographical Regions
- North America
- Europe
- Asia- Pacific
- Rest of the World
VECTOR PURIFICATION MARKET: GROWTH AND TRENDS
Viral vectors are the biological tools that are used to transport genetic material to the target cell. Despite being a complex and resource-intensive process, development and manufacturing of cell and gene therapies has gained substantial momentum, with an increasing number of clinical programs moving to later-phase clinical trials and towards market approval. There are currently over 30 commercially available cell and gene therapy products, along with hundreds of ongoing clinical trials for these innovative therapies. Further, the COVID-19 pandemic has led to a notable rise in the number of therapies that are currently under intervention in clinical trials. However, the current purification methods for viral vectors involve a multitude of steps, which are known to be associated with high product losses and lower yields.
Gradually, rising demand for viral vectors coupled with lack of scalability and other concerns related to downstream purification, have led stakeholders in this domain to undertake various initiatives to develop novel and effective solution for virus purification. Recently, stakeholders have begun relying more on affinity chromatography-based virus purification regimens. Further, there are several companies that claim to offer a diverse range of innovative solutions for vector purification, including filter plates, prepacked chromatography columns and resins, and consolidated kits.
VECTOR PURIFICATION MARKET: KEY INSIGHTS
The report delves into the current state of the global vector purification market and identifies potential growth opportunities within industry. Some key findings from the report include:
- Over 100 viral vector purification products, involving the use of a variety of downstream processing techniques, have been developed to improve virus recovery and facilitate effective removal of contaminants / impurities.
- Most of the available virus purification products have been designed for small / clinical scale use, catering to specific requirements of different types of vectors; North America emerged as the hub of development of such solutions.
- Given the surge in R&D on viral vector-based vaccines in the current crisis, the demand for large scale virus purification solutions is anticipated to be on the rise.
- Adenoviral vectors are widely used in cell and gene therapies; hence, several players offer products, such as kits, resins and columns, for such viruses.
- Majority of developers are based in North America; Bio-Rad Laboratories, Cytiva and Thermo Fisher Scientific are some of the large players based in the region.
- Over the years, more than 1,000 clinical trials, evaluating various viral vector-based therapies and vaccines, across a wide range of diseases, have been registered and are being conducted in different global regions.

- In order to augment and further optimize existing virus purification processes, several viral vector drug developers and manufacturers are likely to forge alliances with purification product developers.
- Over 35 players across the globe are capable of manufacturing different types of viral vectors at commercial scale, either for in-house requirements or as part of contract manufacturing engagements.
- Owing to the rise in R&D initiatives focused on viral cell and gene therapies, the clinical and commercial demand for various types of viral vectors is expected to increase, across a variety of therapeutic indications.
- Since only a few genetically modified therapies have been approved, the current demand is being driven by the patients enrolled in various clinical trials for viral vector-based therapies.
- Currently, over 40% of commercial demand is attributed to adenoviruses due to their wide use in marketed therapies; further, lentiviruses contribute to about 35% of the clinical demand.
- Majority of viral vectors are being developed for patients suffering from oncological disorders; in the coming years, neurological disorders and muscular disorders, are likely to generate a significant demand.
- The market is anticipated to grow at a CAGR of over 21% during the forecast period, and the opportunity is likely to be distributed across different types of purification techniques, viral vectors and key geographical regions.

Example Players in the Vector Purification Market
- Agilent Technologies
- BIA Separations
- Bio-Rad Laboratories
- BioVision
- Cytiva (formerly GE Lifesciences)
- Merck
- Sartorius
- Takara Bio
- Thermo Fisher Scientific
VECTOR PURIFICATION MARKET: RESEARCH COVERAGE
- Market Sizing and Opportunity Analysis: The report features an in-depth analysis of the vector purification market, focusing on key market segments, including [A] type of viral vector, [B] type of purification technique, [C] type of therapy, [D] therapeutic area, [E] scale of operation and [F] key geographical regions.
- Market Landscape: A comprehensive evaluation of companies providing products for purification of viruses / viral vectors, based on several relevant parameters, such as [A] type of product, [B] type of purification technique, [C] scale of operation, [D] type of viral vector and [E] details on other physical and operational parameters of the product. Additionally, a comprehensive evaluation of purification product developers, based on parameters, such as [A] the year of establishment, [B] company size and [C] location of headquarters.
- Company Profiles: In-depth profiles of the players engaged in this domain, focusing on [A] overview of the company, [B] product portfolio and [C] recent developments and an informed future outlook.
- Strategic Partner Analysis: A detailed analysis of the potential strategic partners for viral vector purification product developers, based on various parameters, such as [A] type of viral vector, [B] developer strength, [C] operational strength, [D] therapeutic area, [E] strength of clinical pipeline and [F] strength of preclinical pipeline.
- Clinical Trial Analysis: An in-depth analysis of clinical studies of different viral-vector based therapies, examining factors, such as [A] registration year, [B] phase of development, [C] trial status, [D] type of therapy, [E] therapeutic area, [F] type of sponsor / collaborator, [G] geographical location, [H] number of patients enrolled and [I] key players.
- Demand Analysis: A detailed analysis of the current and future demand for viral vectors, based on various parameters, such as [A] target patient population, [B] dosing frequency, [C] dose strength, [E] type of viral vector, [F] type of therapy, [G] therapeutic are and [h] geographical location.
- Case Study 1: A detailed discussion on tangential flow filtration (TFF), representing the role, advantages and disadvantages of the various techniques used for purification of viral vectors; featuring the details of products used for TFF, including [A] product type, [B] scale of operation, [C] membrane material, [D] flow rate and [E] filtration area.
- Case Study 2: Elaborate assessment of viral vector manufacturers providing commercial scale production, focusing on details, such as [A] year of establishment, [B] company size, [C] type of viral vector, [D] purpose of production, [E] location of headquarters and [F] manufacturing facilities.
KEY QUESTIONS ANSWERED IN THIS REPORT
- How many companies are currently engaged in this market?
- Which are the leading companies in this market?
- What factors are likely to influence the evolution of this market?
- What is the current and future market size?
- What is the CAGR of this market?
- How is the current and future market opportunity likely to be distributed across key market segments?
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