FC AND GLYCOENGINEERED ANTIBODIES MARKET: OVERVIEW
As per Roots Analysis, the global Fc and glycoengineered antibodies market is valued at USD 38.8 billion in the current year and is expected to grow at a lucrative CAGR during the forecast period, till 2035.
The market sizing and opportunity analysis has been segmented across the following parameters:
Type of Engineering
- Fc Engineered Antibodies
- Glycoengineered Antibodies
Type of Therapy
- Monotherapy
- Combination Therapy
- Both
Therapeutic Area
- Autoimmune Disorders
- Dermatological Disorders
- Oncological Disorders
- Rare Diseases
- Other Disorders
Route of Administration
- Intravenous Route
- Subcutaneous Route
- Intramuscular Route
Key Geographical Regions
- North America
- Europe
- Asia-Pacific
- Rest of the World
FC AND GLYCOENGINEERED ANTIBODIES MARKET: GROWTH AND TRENDS
With close to 100 approved monoclonal antibodies, and over 550 molecules in the clinical pipeline, antibody based pharmacological interventions have become one of the fastest growing segments of the biopharmaceutical industry. Further, within the antibody therapeutics industry, engineered antibodies, developed by modifying the fragment crystallizable (Fc) region, have garnered significant interest over the past few years. The modifications, such as glycoengineered antibodies, protein engineering or isotype chimerism in the Fc fusion protein of an antibody have shown to augment the various effector functions, such as antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), antibody-dependent cellular phagocytosis (ADCP) activity and / or the half-life of the molecule. Moreover, several Fc engineering technologies enable the suppression of the effector functions in certain pathways and are being actively explored for development of anti-cancer antibodies.

The consistent research efforts in this domain have resulted into the emergence of two groundbreaking drugs, namely Gazyva (for Chronic Lymphocytic Leukemia) and POTELEGIO (for Sezary syndrome). Further, several other Fc engineered antibody products, including Margenza, MONJUVI and SKYRIZI have also received approval in the past few years. More recently, Fc engineered antibody, named Epcoritamab, received approval for the treatment of diffuse large B-cell lymphoma. Further, there are several drugs in the development pipeline, which are being investigated by various small and established pharmaceutical companies. With the promising clinical results coupled with ongoing technological developments, the market for Fc engineered antibodies is likely to evolve at a commendable pace over the next decade.
FC AND GLYCOENGINEERED ANTIBODIES MARKET: KEY INSIGHTS
The report delves into the current state of the Fc and glycoengineered antibodies market and identifies potential growth opportunities within industry. Some key findings from the report include:
- Fc engineered antibodies pipeline features more than 40 marketed drugs, and 131 drug development programs intended for the treatment of various diseases; these are primarily developed by mid and large-sized players.
- Majority (62%) of the interventions targeting oncological disorders are in clinical phase of development; of these, most (81%) of the antibodies are Fc engineered.

- Close to 150 grants have been awarded in the past few years in the domain of Fc engineered and glycoengineered antibodies; NIAID emerged as the top funding institute for these grants.
- Over time, the intellectual property related to Fc engineered and glycoengineered antibodies has grown at a commendable pace, with patents being filed by both industry and non-industry players.
- Close to half a million patients have been recruited / enrolled in clinical trials registered for the evaluation of Fc engineered and glycoengineered antibodies, across different geographies.
- Since 2016, more than 70 agreements have been inked by various industry and non-industry players, in order to further enhance their manufacturing portfolio related to pharmaceutical contract manufacturing.
- Driven by the promising development pipeline, the market for Fc engineered and glycoengineered antibodies is likely to grow at a steady pace in the coming years.

- In terms of revenues from the sales of marketed and late-stage therapies, the future opportunity is anticipated to be well dispersed across different types of therapy across the globe.
FC AND GLYCOENGINEERED ANTIBODIES MARKET: KEY SEGMENTS
Fc Engineered Antibodies Segment holds the Largest Share of the Fc and Glycoengineered Antibodies Market
Based on the type of Fc engineering, the market is segmented into Fc engineered antibodies and glycoengineered antibodies. At present, the Fc engineered antibodies segment holds the maximum share of the global Fc and glycoengineered antibodies market. This trend is likely to remain the same in the coming years owing to the fact that Fc engineering enhances effector functions, improving the therapeutic efficacy of the modality.
By Type of Therapy, Monotherapy Segment Accounts for the Largest Share of the Global Fc and Glycoengineered Antibodies Market
Based on the type of therapy, the market is segmented into monotherapy, combination therapy and both. Currently, the monotherapy segment captures the highest proportion of the global Fc and glycoengineered antibodies market owing to the several benefits associated with monotherapy, such as easy regulatory pathways, reduced potential drug interactions and cost effectiveness.
By Therapeutic Area, Autoimmune Disorders is the Fastest Growing Segment of the Global Fc and Glycoengineered Antibodies Market
Based on the therapeutic area, the market is segmented into autoimmune disorders, dermatological disorders, oncological disorders, rare diseases and other disorders. At present, the oncological disorders segment holds the maximum share of the global Fc and glycoengineered antibodies market. However, the market for autoimmune disorders segment is expected to grow at a higher CAGR during the forecasted period.
The Intravenous Route Segment Account for the Largest Share of the Global Fc and Glycoengineered Antibodies Market
Based on the route of administration, the market is segmented into intravenous route, subcutaneous route and intramuscular route of administration. Currently, the global Fc and glycoengineered antibodies market is dominated by the Fc and glycoengineered antibodies for intravenous route of administration. This is due to the fact that intravenous route provides complete systemic distribution of antibodies facilitating enhanced therapeutic efficacy and bioavailability.
North America Accounts for the Largest Share of the Market
Based on key geographical regions, the market is segmented into North America, Europe, Asia-Pacific and Rest of the World. Currently, North America dominates the global Fc and glycoengineered antibodies market and accounts for the largest revenue share. Further, the market Asia-Pacific is likely to grow at a higher CAGR in the coming future.
Example Players in the Fc and Glycoengineered Antibodies Market
- AbbVie
- Akesobio
- Alexion Pharmaceuticals
- Amgen
- AstraZeneca
- Boehringer Ingelheim
- Genentech
- MacroGenics
- MorphoSys
- Kyowa Kirin
- Xencor
FC AND GLYCOENGINEERED ANTIBODIES MARKET: RESEARCH COVERAGE
- Market Sizing and Opportunity Analysis: The report features an in-depth analysis of the global Fc and glycoengineered antibodies market, focusing on key market segments, including [A] type of engineering, [B] type of therapy, [C] therapeutic area, [D] route of administration and [E] key geographical regions.
- Market Landscape: A comprehensive evaluation of Fc and glycoengineered antibodies, based on several relevant parameters, such as [A] phase of development, [B] type of engineering, [C] impact of engineering, [D] biological target, [E] type of therapy, [F] target disease indication, [G] therapeutic area, [H] route of administration and [I] popular Fc engineering technologies.
- Company Profiles: In-depth profiles of key players that are currently involved in the development of Fc engineered antibodies, focusing on [A] overview of the company, [B] financial information (if available) [C] drug portfolio and [D] recent developments and an informed future outlook.
- Clinical Trial Analysis: An insightful analysis of clinical trials related to Fc and glycoengineered antibodies, based on several parameters, such as [A] trial registration year, [B] trial status, [C] trial phase, [D] enrolled patient population, [E] type of sponsor, [F] most active industry players (in terms of number of trials conducted), [F] study design, [G] target indication and [H] key geographical regions.
- Partnerships and Collaborations: An insightful analysis of the deals inked by stakeholders in this domain, based on several parameters, such as [A] year of partnership, [B] type of partnership, [C] type of engineering, [D] therapeutic area, [E] most active players (in terms of the number of partnerships signed) and [F] regional distribution of the companies involved in these agreements.
- Grants Analysis: A comprehensive assessment of grants that have been awarded to research institutes for projects related to Fc and glycoengineered antibodies, based on various relevant parameters, such as [A] year of grant award, [B] amount awarded, [C] funding institute center, [D] support period, [E] type of grant application, [F] purpose of grant award, [G] activity code, [H] study section involved, [I] most popular NIH departments, [J] prominent program officers and [K] popular recipient organizations.
- Patent Analysis: An in-depth analysis of patents filed / granted till date related to Fc and glycoengineering antibodies, based on various relevant parameters, such as [A] type of patent, [B] publication year, [C] application year, [D] type of applicant, [E] geographical location, [E] CPC symbols, [F] most active players and [G] patent valuation analysis.
KEY QUESTIONS ANSWERED IN THIS REPORT
- How many companies are currently engaged in this market?
- Which are the leading companies in this market?
- What factors are likely to influence the evolution of this market?
- What is the current and future market size?
- What is the CAGR of this market?
- How is the current and future market opportunity likely to be distributed across key market segments?
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