GLOBAL AAV VECTOR MARKET: OVERVIEW
The global AAV vector market estimated to be 3.6 billion in the current year and USD 6.0 billion by 2035, representing a CAGR of 5.3% during the forecast period.
The market sizing and opportunity analysis has been segmented across the following parameters:
Type of Therapy
- Gene Augmentation Therapies
- Gene Regulation Therapies
Therapeutic Area
- Oncological Disorders
- Rare Disorders
- Neurological Disorders
- Metabolic Disorders
- Musculoskeletal Disorders
- Dermatological Disorders
- Infectious Diseases
- Cardiovascular Disorders
- Genetic Disorders
- Ophthalmic Disorders
- Other Disorders
Route of Administration
- Intravenous Route
- Subretinal Route
- Intravitreal Route
- Other Routes
Scale of Operation
- Preclinical
- Clinical
- Commercial
Key Geographical Regions
- North America
- Europe
- Asia-Pacific
- Middle East and North Africa
- Latin America and Rest of the World
Global AAV Market: Growth and Trends
In the last few years, the demand for gene therapies has surged owing to their potential in targeting the underlying cause of a disease at cellular level. Presently, over 2,000 gene therapies are being evaluated in different phases of clinical development. This increasing interest in such therapies has resulted in an increase in the demand for novel delivery vectors. AAV vectors have emerged the most efficient viral vectors, among the various gene delivery vectors available. In the present year, six AAV based gene therapies have been approved for various indications. The current market dynamics suggest that close to 290 players across the globe are developing AAV vector-based therapies in order to cater to their increasing demand.
The AAV technology has a history spanning over 50 years and is consistently advancing, becoming one of the most widely utilized gene delivery systems for gene therapy purposes. Additionally, due to its uncomplicated structure, and absence of disease association, AAV vector is the most favored vector for numerous medical applications. Lately, the AAV vector market has encountered competition from various viral and non-viral systems that enable the delivery of larger genetic material. Additional complexity arises from the difficulties associated with scaling up GMP AAV production processes.
Given the current trends and anticipated opportunities in the AAV viral vector sector, we anticipate that this field will experience notable growth in the near future.
Global AAV Market: Key Insights
The report delves into the current state of global AAV viral vector market and identifies potential growth opportunities within industry. Some key findings from the report include:
- Close to 635 adeno-associated viral vector-based therapies are being evaluated by stakeholders in this domain for various disease indications.
- Most (42%) therapies are in preclinical stage of development, followed by those in clinical stage (30%); majority of the therapies presently use gene augmentation approach in order to treat several diseases.
- Presently, close to 95 players across the globe claim to offer their services across various scale of operations in order to support the development of AAV therapies; notably, majority of these firms are based in North America.
- Several stakeholders have made significant efforts in order to develop adeno-associated viral vector-based therapies, across the globe; majority of these players have been established post-2010.
- 55 adeno-associated viral vector technologies / platforms are currently available in the market; these can be used by various manufacturers in order to cater the increasing demand for AAV therapies.
- All the technologies / platforms developed by companies engaged in this domain are focused on adeno-associated viral vectors manufacturing; of these, majority are being developed against neurological disorders.
- Majority (65%) of the trials were registered in the last three years; a significant proportion of these trials are currently under early stages of research (phase I and phase II).

- Mergers and acquisitions (22%) emerged as the preferred type of partnership model adopted by industry stakeholders, as it enables companies to enter new markets and expand their product portfolios.
- Over 1,600 patents have been published in the adeno-associated viral vector domain since 2021; of these, over 60% of the patents have been filed in the last five years.
- The future opportunity, in terms of revenues generated from marketed and late-stage therapies, is anticipated to be well distributed across different therapeutic disorders, type of therapy and route of administration.
- The market is likely to witness an annualized growth of 7.7% during the forecast period owing to various benefits offered by AAV manufacturing techniques, including high target specificity and broad tissue tropism.
Global AAV Market: Key Segments
Muscle-related Disorders Segment is Likely to Hold the Largest Market Share
In terms of therapeutic area, the market is segmented across muscle-related disorders, genetic disorders, hematological disorders, ophthalmic disorders, dermatological disorders and metabolic disorders. In the current year, the muscle-related disorders segment occupies the higher AAV vector market share (53%), owing to the increasing adoption of AAV vector-based therapies in the treatment of severe muscle disorders, specifically Duchenne muscular dystrophy (DMD) and spinal muscular atrophy.
Gene Augmentation Therapies Segment Holds the Largest Market Share
In terms of type of therapy, the global AAV vector-based therapies market is segmented across gene augmentation therapies and gene regulation therapies. In the current year, the revenues generated by the sales of gene augmentation therapies completely drive the AAV vector-based therapies industry. Further, the market is likely to witness a considerable increase in the share of gene regulation therapies, growing at a CAGR of 61% during the forecast period.
Intravenous Route Segment Holds the Largest Market Share
In terms of route of administration, the AAV vector based therapies industry is segmented across intravenous route, subretinal route, intravitreal route and other routes. In the current year, intravenous route segment occupies the highest market share due to the ability of intravenous route to deliver therapy quickly and evenly across the entire body. In addition, the market is anticipated to witness a considerable increase in the share of therapies administered via intravitreal route, growing at a CAGR of 64% during the forecast period. This is an outcome of the increasing number of AAV based therapy approvals for ophthalmic disorders, for which intravitreal route has emerged as the primary route.
Europe is likely to Propel in the AAV vector based Therapies Market in the Coming Years
This segment highlights the distribution of AAV vector based therapies market across various geographical regions, namely North America, Europe, Asia-Pacific and Latin America, and rest of the world. Our estimates suggest that North America is likely to capture the majority (~75%) of the AAV vector based therapies market share in the current year. This can be attributed to the availability of advanced healthcare infrastructure within this region to conduct a large number of clinical trials.
Example Players in the AAV Market
- Astellas Pharma
- Charles River Laboratories
- Lonza
- Patheon pharma services
- Sanofi
- WuXi AppTec
- Sarepta Therapeutics
- Uniqure
- Spark Therapeutics
- PTC Therapeutics
- Biomarin Pharmaceutical
- Novartis
Global AAV Market: Research Coverage
- Market Sizing and Opportunity Analysis: The report features an in-depth analysis of the global AAV vector market, focusing on key market segments, including [A] type of therapy, [B] therapeutic area, [C] route of administration, [D] scale of operation and [E] geographical regions.
- Adeno-associated Viral Vector Manufacturing Market Landscape: The report features an in-depth analysis of the global AAV vector market, focusing on key market segments, including [A] status of development, [B] therapeutic area, [C] type of gene / molecule targeted, [D] type of therapy, [E] gene delivery method used, [F] route of administration, [G] special designation awarded, [H] year of establishment, [I] company size, and [J] location of headquarters.
- Adeno-associated Viral Vector Manufacturing Market Technologies / Platforms Landscape: A comprehensive evaluation of adeno-associated viral vector manufacturing technologies / platforms, considering various parameters, such as [A] type of vector manufactured, [B] type of viral vector manufactured, [C] scale of operation [D] application area [E] therapeutic area, [F] year of establishment, [G] company size, and [H] location of headquarters .
- Company Competitiveness Analysis: A comprehensive competitive analysis of AAV viral vector manufacturers, examining factors, such as [A] manufacturer strength and [B] product portfolio strength.
- Technology Competitiveness Analysis: A comprehensive competitive analysis of AAV viral vector manufacturing technologies, examining factors, such as [A] supplier power and [B] key technology specifications.
- Company Profiles: In-depth company and drug profiles of the players, focusing on [A] company overview, [B] financial information (if available), [C] drug portfolio and [D] recent developments and an informed future outlook.
- Clinical Trial Analysis: An insightful analysis of clinical studies, based on several parameters, such as [A] trial registration year, [B] current status, [C] phase of development, [D], enrolled patient population [E] type of sponsor / collaborator and [F] regional distribution of trials.
- Partnerships and Collaborations: An in-depth analysis of the deals inked by stakeholders in the AAV vector manufacturing market, based on several parameters, such as [A] year of partnership, [B] type of partnership, [C] therapeutic area, [D] application area, [E] geographical distribution [F] most active players (in terms of number of partnerships).
- Likely Partners Analysis: A detailed review of the companies with the likelihood of establishing partnerships with adeno-associated viral vector and gene therapy product manufacturers, based on several parameters, such as [A] developer strength, [B] product strength, [C] therapeutic capability and [D] pipeline strength.
- Patent Analysis: An in-depth analysis of patents filed / granted till date in the AAV vector manufacturing domain, based on various relevant parameters, such as [A] type of patent, [B] publication year, [C] regional applicability, [D] CPC symbols, [E] emerging focus areas, [F] leading industry / non-industry players and [G] patent valuation.
- Start-up Health Indexing: A comprehensive analysis of the various start-ups engaged in the development of adeno-associated viral vectors-based therapies, based on relevant parameters, such as [A] number of candidates in discovery, preclinical and clinical phases of development, [B] number of patents and [C] number of partnerships established.
- Outsourcing: Go / No-Go Framework: An exhaustive study of the various factors that need to be taken into consideration by adeno-associated viral vector manufacturers to facilitate decision making to manufacture their respective products in-house or engage the services of a CMO.
Key Questions Answered in this Report
- How many companies are currently engaged in this market?
- Which are the leading companies in this market?
- What factors are likely to influence the evolution of this market?
- What is the current and future market size?
- What is the CAGR of this market?
- How is the current and future market opportunity likely to be distributed across key market segments?
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- The report provides a comprehensive market analysis, offering detailed revenue projections of the overall market and its specific sub-segments. This information is valuable to both established market leaders and emerging entrants.
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