PUBLISHER: The Business Research Company | PRODUCT CODE: 1750907
PUBLISHER: The Business Research Company | PRODUCT CODE: 1750907
Anticoagulant reversal drugs are medications used to counteract the effects of anticoagulants, helping restore normal blood clotting in patients experiencing excessive bleeding. These drugs are typically administered in emergency situations, such as life-threatening hemorrhages or urgent surgeries, to quickly reverse anticoagulation and prevent severe complications.
Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report's Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.
The primary anticoagulant reversal drugs include prothrombin complex concentrates, phytonadione (vitamin K), andexanet alfa, idarucizumab, protamine, and others. Prothrombin complex concentrates (PCCs) are blood-derived products containing clotting factors that help manage excessive bleeding. They can be administered via both injectable and oral routes and are distributed through hospital pharmacies, retail pharmacies, and online pharmacies. PCCs are used for reversing direct oral anticoagulants (DOACs), warfarin, heparin, low-molecular-weight heparin (LMWH), and other anticoagulant treatments.
The anticoagulant reversal drugs market research report is one of a series of new reports from The Business Research Company that provides anticoagulant reversal drugs market statistics, including anticoagulant reversal drugs industry global market size, regional shares, competitors with a anticoagulant reversal drugs market share, detailed anticoagulant reversal drugs market segments, market trends and opportunities, and any further data you may need to thrive in the anticoagulant reversal drugs industry. This anticoagulant reversal drugs market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The anticoagulant reversal drugs market size has grown strongly in recent years. It will grow from$1.52 billion in 2024 to $1.68 billion in 2025 at a compound annual growth rate (CAGR) of 10.6%. The growth during the historic period can be attributed to the increase in bleeding disorders, the growing elderly population, expanded healthcare spending, a rise in the prevalence of strokes, and increased investments in the pharmaceutical sector.
The anticoagulant reversal drugs market size is expected to see strong growth in the next few years. It will grow to$2.48 billion in 2029 at a compound annual growth rate (CAGR) of 10.2%. The growth during the forecast period can be attributed to the rising demand for antidotes, improvements in healthcare infrastructure, an increasing incidence of thromboembolic disorders, a growing prevalence of cardiovascular diseases, and expanded awareness campaigns. Key trends expected in the forecast period include technological advancements, AI-driven drug discovery, progress in nanomedicine, the integration of digital health solutions, and the use of blockchain in drug supply management.
The growing prevalence of cardiovascular diseases (CVDs) is expected to drive the expansion of the anticoagulant reversal drugs market. CVDs, which encompass heart and blood vessel disorders such as coronary artery disease, stroke, and heart failure, are on the rise, largely due to poor lifestyle choices. Factors such as increased consumption of processed foods, lack of physical activity, and high stress levels contribute to obesity, hypertension, and diabetes. Patients with CVDs often require anticoagulant reversal drugs to mitigate excessive bleeding risks, as individuals on blood thinners for conditions such as atrial fibrillation or deep vein thrombosis may face life-threatening hemorrhages that demand quick intervention to restore normal blood clotting. For example, in December 2024, the Office for Health Improvement and Disparities reported that, in the financial year ending March 2023, 1,879,000 people (3%) in England had a GP diagnosis of coronary heart disease (CHD). Regional variations in heart failure admission rates were more pronounced than for CHD, with a fourfold difference observed, peaking at 396.5 admissions per 100,000 people in Hounslow. This surge in cardiovascular diseases is, therefore, fueling the growth of the anticoagulant reversal drugs market.
Key players in the anticoagulant reversal drugs market are focusing on innovation, particularly the development of new reversal agents, to enhance treatment effectiveness and ensure patient safety. These reversal agents are specialized therapeutics designed to rapidly and selectively counteract the effects of anticoagulants, providing swift and efficient reversal of blood-thinning medications. For example, in March 2022, AstraZeneca plc, a UK-based pharmaceutical and biotechnology company, received approval for Ondexxya (andexanet alfa) in Japan to reverse the effects of Factor Xa inhibitors (such as apixaban, rivaroxaban, and edoxaban) during life-threatening bleeds. This was the first approved drug in Japan for this purpose, based on the ANNEXA-4 trial, which demonstrated its ability to rapidly and effectively reverse anti-FXa activity. This approval addresses the major bleeding risks associated with these commonly prescribed anticoagulant drugs.
In February 2025, Novartis AG, a pharmaceutical giant based in Switzerland, acquired Anthos Therapeutics Inc. for $3.1 billion. This acquisition aims to bolster Novartis's cardiovascular portfolio with abelacimab, a next-generation anticoagulant designed to reduce blood clot risks while minimizing bleeding complications. Anthos Therapeutics Inc., a US-based biopharmaceutical company, specializes in developing innovative anticoagulant therapies to address thrombosis-related disorders.
Major players in the anticoagulant reversal drugs market are Pfizer Inc., Bristol-Myers Squibb Company, AstraZeneca PLC, Takeda Pharmaceutical Company Limited, Teva Pharmaceutical Industries Ltd., Boehringer Ingelheim International GmbH, CSL Behring LLC, Daiichi Sankyo Company Limited, Avantor Inc., Daicel Pharma Services GmbH, Octapharma AG, Dr. Reddy's Laboratories Ltd., Amneal Pharmaceuticals LLC, AMAG Pharmaceuticals Inc, Glenmark Pharmaceuticals Inc USA, Alexion Pharmaceuticals Inc, Amphastar Pharmaceuticals Inc, Portola Pharmaceuticals Inc, Transo-Pharm USA LLC, and Join Hub Pharma.
North America was the largest region in the anticoagulant reversal drugs market in 2024. The regions covered in anticoagulant reversal drugs report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.
The countries covered in the anticoagulant reversal drugs market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The anticoagulant reversal drugs market consists of sales of fresh frozen plasma, tranexamic acid, desmopressin, activated charcoal, and recombinant factor vIIa. Values in this market are 'factory gate' values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Anticoagulant Reversal Drugs Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses on anticoagulant reversal drugs market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for anticoagulant reversal drugs ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The anticoagulant reversal drugs market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.