PUBLISHER: The Business Research Company | PRODUCT CODE: 1751037
PUBLISHER: The Business Research Company | PRODUCT CODE: 1751037
Leber hereditary optic neuropathy (LHON) treatment involves medical strategies designed to manage or alleviate the effects of LHON, a rare genetic condition that leads to sudden vision loss, most often in young adults. This disorder is caused by mutations in mitochondrial DNA, which result in degeneration of the optic nerve due to impaired function of retinal ganglion cells, leading to significant vision impairment.
Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report's Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.
Primary treatment options for LHON include medication, stem cell therapy, gene therapy, and genetic counseling. Medications help manage symptoms by addressing underlying causes and may be administered in forms such as tablets or injections to reduce inflammation, support nerve health, and treat conditions associated with LHON. These treatments are delivered through various routes, including intramuscular, oral, and others. Diagnosis is made using a range of methods such as molecular genetic testing, magnetic resonance imaging (MRI), and blood tests. Treatments are distributed through hospital pharmacies, retail pharmacies, and online pharmacies, and are used by a variety of end-users, including clinics, hospitals, and other healthcare facilities.
The leber hereditary optic neuropathy treatment market research report is one of a series of new reports from The Business Research Company that provides leber hereditary optic neuropathy treatment market statistics, including the leber hereditary optic neuropathy treatment industry global market size, regional shares, competitors with the leber hereditary optic neuropathy treatment market share, detailed leber hereditary optic neuropathy treatment market segments, market trends, and opportunities, and any further data you may need to thrive in the leber hereditary optic neuropathy treatment industry. This leber hereditary optic neuropathy treatment market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.
The leber hereditary optic neuropathy treatment market size has grown strongly in recent years. It will grow from $0.36 billion in 2024 to $0.39 billion in 2025 at a compound annual growth rate (CAGR) of 8.1%. The growth during the historic period can be attributed to the rising prevalence of Leber hereditary optic neuropathy, an aging population, an increasing incidence of diabetes, growing demand for cell-free DNA in maternal plasma testing, and increased investment in the healthcare sector.
The leber hereditary optic neuropathy treatment market size is expected to see strong growth in the next few years. It will grow to $0.53 billion in 2029 at a compound annual growth rate (CAGR) of 7.8%. The anticipated growth in the forecast period can be attributed to the rising demand for innovative therapies and interventions, increasing need for specialized diagnostic services, greater awareness and early detection of optic neuropathies, growing interest in novel treatments for LHON, and ongoing advancements in product design and quality improvement. Key trends expected during this period include the development of targeted therapies, progress in genetic testing technologies, advancements in both surgical and pharmacological treatment options, innovations in gene therapy techniques, and the broader expansion of gene therapy applications.
The increasing incidence of glaucomas and optic neuritis is expected to contribute significantly to the growth of the Leber hereditary optic neuropathy (LHON) treatment market in the coming years. Glaucoma and optic neuritis are eye disorders that result in damage to the optic nerve, with glaucoma commonly caused by elevated intraocular pressure, and optic neuritis typically associated with inflammation linked to autoimmune conditions, both potentially leading to vision loss. The growing occurrence of these conditions is largely attributed to an aging population and advancements in diagnostic technologies. As the global population continues to age, the risk of developing glaucoma characterized by optic nerve damage due to increased intraocular pressure rises markedly. Both glaucoma and optic neuritis involve optic nerve degeneration, a condition similar to LHON. With the rising prevalence of these disorders, research and awareness efforts are becoming more focused on therapies targeting optic nerve damage, which also aids in advancing treatment options for LHON. For example, in October 2024, the Centers for Disease Control and Prevention reported that over 3 million Americans currently suffer from glaucoma, a number expected to double to 6.3 million by 2050 due to the aging population. This trend is contributing to the growing demand for LHON treatment solutions.
Advancements in targeted therapies are also playing a key role in driving innovation in the genetic treatment of vision-related disorders. Leading companies in the LHON treatment market are prioritizing the development of cutting-edge treatments, including gene therapy clinical trials, with the aim of enhancing therapeutic efficacy, restoring mitochondrial function, and addressing the genetic basis of LHON. These gene therapy initiatives are designed to restore vision by delivering functional copies of defective mitochondrial genes, such as ND4. These treatments undergo rigorous phases, from preclinical studies through to phase 1, 2, and 3 clinical trials, before regulatory approval can be granted. For instance, in August 2023, Neurophth Therapeutics, a gene therapy company based in China, launched a Phase I/II clinical trial for ND1-LHON treatment in China and the United States. This trial, which received approval from both the U.S. FDA and China's NMPA, aims to assess the safety, tolerability, and effectiveness of its NFS-02 therapy. The dosing of the first patient marked a significant milestone in the company's global development strategy, as it continues to accelerate patient recruitment and explore further gene therapy solutions for other rare and unmet medical needs.
In July 2023, Chiesi Farmaceutici S.p.A., an Italy-based company specializing in research-driven healthcare solutions, acquired the Raxone/idebenone business from Santhera Pharmaceuticals for an undisclosed sum. This acquisition is intended to enhance Chiesi's rare disease portfolio and reinforce its position in the treatment of Leber hereditary optic neuropathy (LHON). Santhera Pharmaceuticals, based in Switzerland, focuses on developing treatments for LHON.
Major players in the leber hereditary optic neuropathy treatment market are UPMC, Astellas Pharma Inc., Mayo Foundation for Medical Education and Research, Cleveland Clinic Foundation, The Children's Hospital of Philadelphia, Chiesi Farmaceutici S.p.A., Medicover Hospitals, Harvard Medical School, BridgeBio Pharma Inc., Neurophth Therapeutics Co. Ltd., PreventionGenetics, Stealth BioTherapeutics Corp., Genethon, Reneo Pharmaceuticals Inc., GenSight Biologics S.A., Eye Stem Cell Center, Khondrion B.V., Ixchel Pharma Inc., Abliva AB, Mitotech S.A.
North America was the largest region in the leber hereditary optic neuropathy treatment market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in leber hereditary optic neuropathy treatment report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.
The countries covered in the leber hereditary optic neuropathy treatment market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The leber hereditary optic neuropathy treatment market consists of revenues earned by entities providing services such as mitochondrial support therapies, diagnostic testing, and vision rehabilitation services. The market value includes the value of related goods sold by the service provider or included within the service offering. The leber hereditary optic neuropathy (LHON) treatment market also includes sales of antioxidants and supportive care medications aimed at managing vision loss and disease progression. Values in this market are 'factory gate' values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Leber Hereditary Optic Neuropathy Treatment Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses on leber hereditary optic neuropathy treatment market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for leber hereditary optic neuropathy treatment ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The leber hereditary optic neuropathy treatment market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.