PUBLISHER: The Business Research Company | PRODUCT CODE: 1751144
PUBLISHER: The Business Research Company | PRODUCT CODE: 1751144
Treatment-resistant depression (TRD) is a severe and persistent form of major depressive disorder (MDD) that is characterized by an inadequate response to at least two different antidepressant treatments, each given at an adequate dose and duration. This condition leads to prolonged psychological distress and functional impairment. Individuals with TRD often require advanced therapeutic approaches, including novel pharmacological treatments, neuromodulation techniques, and personalized mental health interventions, to achieve symptom relief and improve overall well-being.
Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report's Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.
The main drug classes used in the treatment of treatment-resistant depression include selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors, tricyclic antidepressants, psychedelics, and others. SSRIs are a class of antidepressants that work by increasing serotonin levels in the brain, inhibiting its reabsorption into neurons, which enhances mood regulation and helps treat conditions such as depression and anxiety disorders. These medications are administered through various routes, including oral, parenteral, and others, and are distributed through channels such as hospital pharmacies, retail pharmacies, and online pharmacies. Key end users include hospitals, homecare settings, specialty clinics, and other healthcare providers.
The treatment-resistant depression market research report is one of a series of new reports from The Business Research Company that provides treatment-resistant depression market statistics, including treatment-resistant depression industry global market size, regional shares, competitors with a treatment-resistant depression market share, detailed treatment-resistant depression market segments, market trends and opportunities, and any further data you may need to thrive in the treatment-resistant depression industry. This treatment-resistant depression market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The treatment-resistant depression market size has grown strongly in recent years. It will grow from$1.76 billion in 2024 to $1.88 billion in 2025 at a compound annual growth rate (CAGR) of 7.1%. The growth during the historic period can be attributed to several factors, including the rising cases of treatment-resistant depression, the increasing incidence of depression, improved access to healthcare facilities, growing awareness of available treatment options, and the high prevalence of mental health disorders.
The treatment-resistant depression market size is expected to see strong growth in the next few years. It will grow to$2.46 billion in 2029 at a compound annual growth rate (CAGR) of 6.9%. The growth during the forecast period can be attributed to factors such as the rise in chronic diseases, the increasing prevalence of anxiety disorders, growing awareness of mental health issues, enhanced government initiatives, and higher healthcare expenditure. Key trends expected in the forecast period include the expansion of telemedicine and digital health, advancements in diagnostic and therapeutic technologies, efforts to reduce mental health stigma and raise awareness, the adoption of personalized medicine, and the integration of artificial intelligence in mental health treatment.
The increasing prevalence of mental disorders is expected to drive the growth of the treatment-resistant depression (TRD) market. Mental disorders encompass a wide range of conditions that affect an individual's cognitive, emotional, and behavioral functions, often resulting in significant distress and impairment in daily life. The high prevalence of these disorders is influenced by factors such as genetic predisposition, as inherited genetic variations can alter brain chemistry and increase the susceptibility to conditions such as depression, anxiety, and schizophrenia. TRD provides support for patients by offering more personalized and advanced treatment options when standard therapies fail, thereby improving their chances of recovery and overall quality of life. For example, in November 2023, the American Psychological Association (APA) reported that 50% of adults aged 18 to 34 experienced mental illnesses, the highest rate among age groups, while adults aged 35 to 44 saw the largest increase in diagnoses, with 45% reporting a mental illness. This rise in mental health conditions is contributing to the growth of the treatment-resistant depression market.
Leading companies in the treatment-resistant depression market are focused on developing innovative therapies, such as monotherapy, to address unmet patient needs, improve efficacy, and minimize side effects. Monotherapy involves the use of a single treatment or medication, as opposed to combining multiple therapies, offering a more focused approach to treating treatment-resistant depression. This strategy is particularly beneficial for patients who have not responded to several medications. For example, in January 2025, Johnson & Johnson Services Inc., a US-based pharmaceutical and medical technology company, announced the approval of SPRAVATO (esketamine) nasal spray by the U.S. Food and Drug Administration (FDA) as a fast-acting treatment for adults with treatment-resistant depression. SPRAVATO is used in conjunction with an oral antidepressant when patients have not adequately responded to at least two other antidepressants. The drug's rapid effects address the limitations of traditional antidepressants, which often take weeks to show results. As a derivative of ketamine, esketamine works by targeting the brain's NMDA receptors, potentially improving mood within hours. This approval represents a significant advancement in mental health treatment.
In October 2024, Resilience Lab, a US-based healthcare company, acquired Options MD for an undisclosed amount. This acquisition allows Resilience Lab to enhance its mental health services by integrating Options MD's specialized platform for treating severe and treatment-resistant depression. This move aims to expand access to personalized, evidence-based care. Options MD is a US-based telepsychiatry company specializing in the treatment of severe and treatment-resistant depression, bipolar disorder, post-traumatic stress disorder (PTSD), and other mental health conditions.
Major players in the treatment-resistant depression market are Pfizer Inc., Johnson & Johnson Services Inc., Abbott Laboratories, Novartis AG, GlaxoSmithKline (GSK) plc., Hikma Pharmaceuticals plc, Neurocrine Biosciences Inc., Relmada Therapeutics Inc., Neuronetics Inc., COMPASS Pathways, Lykos Therapeutics, Reviva Pharmaceuticals, Celon Pharma SA, BrainsWay Ltd., Magstim Company Limited, MindMed, Alto Neuroscience, Sage Therapeutics Inc., MindBio Therapeutics Ltd., Reunion Neuroscience.
North America was the largest region in the treatment-resistant depression market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in treatment-resistant depression report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.
The countries covered in the treatment-resistant depression market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The treatment-resistant depression market consists of revenues earned by entities by providing services such as psychiatric counseling, cognitive behavioral therapy (CBT), transcranial magnetic stimulation (TMS) therapy, electroconvulsive therapy (ECT), and ketamine infusion therapy. The market value includes the value of related goods sold by the service provider or included within the service offering. The treatment-resistant depression market includes sales of products such as esketamine nasal spray, vagus nerve stimulation (VNS) devices, deep brain stimulation (DBS) systems, neuromodulation devices, glutamate receptor modulators, and digital therapeutics. Values in this market are 'factory gate' values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Treatment-Resistant Depression Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses on treatment-resistant depression market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for treatment-resistant depression ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The treatment-resistant depression market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.