PUBLISHER: The Business Research Company | PRODUCT CODE: 1810864
PUBLISHER: The Business Research Company | PRODUCT CODE: 1810864
Cytokine-based therapies and inhibitors are medical treatments designed to either stimulate or block cytokine activity-small proteins that regulate immune responses, inflammation, and cell communication. These therapies help manage various conditions like cancer, autoimmune diseases, and inflammatory disorders by modulating immune system functions.
The main categories of cytokine-based therapies and inhibitors include interleukins, tumor necrosis factor, epidermal growth factor, interferons, and chemokines. Interleukins are cytokine proteins produced by immune cells that play a key role in regulating immune responses, inflammation, and cell signaling. These treatments are applied across diverse areas such as cancer, inflammatory and immune disorders, infectious diseases, asthma and airway inflammation, among others. They are used by a range of end users including hospitals, clinics, research laboratories, academic institutions, specialty centers, and more.
Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report's Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.
The sudden escalation of U.S. tariffs and the consequent trade frictions in spring 2025 are severely impacting the pharmaceutical companies contend with tariffs on APIs, glass vials, and lab equipment inputs with few alternative sources. Generic drug makers, operating on razor-thin margins, are especially vulnerable, with some reducing production of low-profit medicines. Biotech firms face delays in clinical trials due to tariff-related shortages of specialized reagents. In response, the industry is expanding API production in India and Europe, increasing inventory stockpiles, and pushing for trade exemptions for essential medicines.
The cytokine-based therapies and inhibitors market research report is one of a series of new reports from The Business Research Company that provides cytokine-based therapies and inhibitors market statistics, including cytokine-based therapies and inhibitors industry global market size, regional shares, competitors with a cytokine-based therapies and inhibitors market share, detailed cytokine-based therapies and inhibitors market segments, market trends and opportunities, and any further data you may need to thrive in the cytokine-based therapies and inhibitors industry. The cytokine-based therapies and inhibitors market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The cytokine-based therapies and inhibitors market size has grown steadily in recent years. It will grow from $140.66 billion in 2024 to $146.95 billion in 2025 at a compound annual growth rate (CAGR) of 4.5%. The growth during the historic period can be linked to the increasing prevalence of autoimmune diseases, a rising incidence of cancer, an expanding burden of infectious diseases, heightened demand for personalized medicine, advancements in vaccine development, and greater awareness of immunotherapies.
The cytokine-based therapies and inhibitors market size is expected to see steady growth in the next few years. It will grow to $173.32 billion in 2029 at a compound annual growth rate (CAGR) of 4.2%. The growth projected for the forecast period can be attributed to the aging global population, increased adoption of targeted therapies, a rising incidence of chronic inflammatory diseases, expansion of clinical trial pipelines, government backing for immunology research, and an increased focus on patient outcomes and safety. Key trends during this period include advancements in protein engineering, development of multi-cytokine inhibitors, application of artificial intelligence in drug discovery, next-generation sequencing for biomarker identification, integration of digital health platforms, and improved formulation technologies for enhanced stability.
The increasing incidences of autoimmune disorders are expected to drive the growth of the cytokine-based therapies and inhibitors market in the future. Autoimmune disorders occur when the immune system mistakenly attacks healthy cells and tissues, treating them as foreign threats. The rise in these disorders is linked to dietary changes, especially the higher consumption of highly processed foods, which can disrupt gut microbiota and impair immune regulation. Cytokine-based therapies and inhibitors work by modulating the immune response through targeting specific cytokines involved in inflammation, making them effective in managing autoimmune conditions. For example, in November 2024, a survey by Versorgungsatlas.de, a Germany-based healthcare information portal, reported that out of 73,241,305 insured individuals in 2022, 6,304,340 were diagnosed with at least one autoimmune disease, reflecting a raw prevalence rate of 8.61%. Thus, the growing incidence of autoimmune disorders is fueling the growth of the cytokine-based therapies and inhibitors market.
Leading companies in the cytokine-based therapy and inhibitor market are developing innovative treatments such as intravesical cytokine maintenance immunotherapy, aimed at enhancing the durability of complete responses and reducing recurrence rates in patients with Bacillus Calmette-Guerin (BCG)-unresponsive non-muscle invasive bladder cancer (NMIBC). This approach involves administering immune-activating proteins directly into the bladder, followed by long-term maintenance doses to continuously stimulate local immune responses and prevent tumor regrowth. For instance, in April 2024, the US Food and Drug Administration approved nogapendekin alfa inbakicept-pmln (Anktiva), a novel cytokine-based therapy used in combination with BCG. Anktiva functions as a fusion protein targeting the interleukin-15 (IL-15) pathway, activating CD122-positive immune cells such as natural killer (NK) cells and CD8-positive T cells. This mechanism reflects the principle of cytokine-based therapy, which uses signaling proteins like IL-15 to boost the body's immune surveillance and anti-tumor activity.
In February 2022, Equillium Inc., a US-based biotechnology company, acquired Bioniz Therapeutics Inc. for an undisclosed sum. Through this acquisition, Equillium expanded its immunology pipeline by obtaining access to Bioniz's proprietary portfolio of cytokine therapies targeting immune-inflammatory diseases and certain cancers, thereby strengthening its position in autoimmune and oncology treatment areas. Bioniz Therapeutics is a US-based biotech firm specializing in the discovery and development of selective cytokine inhibitors for immune-related disorders.
Major players in the cytokine-based therapies and inhibitors market are Pfizer Inc., Johnson & Johnson, F. Hoffmann-La Roche Ltd, AbbVie Inc., Bayer AG, Novartis AG, Sanofi SA, Bristol-Myers Squibb Company, Thermo Fisher Scientific Inc., AstraZeneca Plc, GlaxoSmithKline plc, Eli Lilly and Company, Amgen Inc, Lonza Group AG, Cytiva, UCB S.A., Sartorius CellGenix GmbH, Biocon Limited, Bio-Techne Corporation, and Miltenyi Biotec B.V. & Co. KG.
North America was the largest region in the cytokine-based therapies and inhibitors market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in cytokine-based therapies and inhibitors report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.
The countries covered in the cytokine-based therapies and inhibitors market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The cytokine-based therapies and inhibitors market consists of revenues earned by entities providing services such as the development, manufacturing, and commercialization of cytokine-targeted drugs. The market value includes the value of related goods sold by the service provider or included within the service offering. The cytokine-based therapies and inhibitors market includes sales of products such as colony-stimulating factors, transforming growth factors, and monoclonal antibodies. Values in this market are 'factory gate' values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).
The revenues for a specified geography are consumption values and are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Cytokine-Based Therapies And Inhibitors Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses on cytokine-based therapies and inhibitors market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for cytokine-based therapies and inhibitors ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward, including technological disruption, regulatory shifts, and changing consumer preferences? The cytokine-based therapies and inhibitors market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
The forecasts are made after considering the major factors currently impacting the market. These include the technological advancements such as AI and automation, Russia-Ukraine war, trade tariffs (government-imposed import/export duties), elevated inflation and interest rates.