PUBLISHER: The Business Research Company | PRODUCT CODE: 1826856
PUBLISHER: The Business Research Company | PRODUCT CODE: 1826856
Adenosine deaminase-severe combined immunodeficiency (ADA-SCID) is a rare genetic disorder caused by a deficiency of the enzyme adenosine deaminase, resulting in the toxic accumulation of metabolites that hinder immune cell development. Understanding ADA-SCID is crucial for early diagnosis and management to prevent life-threatening infections and complications.
The primary treatment options for ADA-SCID include enzyme replacement therapy (ERT), gene therapy, stem cell transplantation, and supportive care. ERT involves administering synthetic or recombinant enzymes to compensate for the deficient or absent enzyme in individuals with genetic disorders. These therapies are delivered through various routes, including intravenous, subcutaneous, and oral administration. Designed for both pediatric and adult patients, they are distributed through hospital, retail, and online pharmacies. Key end-users include hospitals, specialty clinics, research institutes, and other healthcare facilities.
Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report's Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.
The sharp rise in U.S. tariffs and the resulting trade tensions in spring 2025 are having a significant impact on the healthcare sector, especially in the supply of essential medical devices, diagnostic equipment, and pharmaceuticals. Hospitals and healthcare providers are grappling with higher costs for imported surgical tools, imaging systems, and consumables like syringes and catheters, many of which have limited domestic substitutes. These escalating expenses are putting pressure on healthcare budgets, prompting some providers to delay equipment upgrades or pass increased costs on to patients. Furthermore, tariffs on raw materials and components are disrupting the manufacturing of vital drugs and devices, leading to supply chain delays. In response, the industry is adopting diversified sourcing strategies, expanding local production where feasible, and pushing for tariff exemptions on critical medical products.
The adenosine deaminase-severe combined immunodeficiency market research report is one of a series of new reports from The Business Research Company that provides adenosine deaminase-severe combined immunodeficiency market statistics, including the adenosine deaminase-severe combined immunodeficiency industry global market size, regional shares, competitors with the adenosine deaminase-severe combined immunodeficiency market share, detailed adenosine deaminase-severe combined immunodeficiency market segments, market trends, and opportunities, and any further data you may need to thrive in the adenosine deaminase-severe combined immunodeficiency industry. This adenosine deaminase-severe combined immunodeficiency market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.
The adenosine deaminase-severe combined immunodeficiency market size has grown strongly in recent years. It will grow from $5.57 billion in 2024 to $5.94 billion in 2025 at a compound annual growth rate (CAGR) of 6.6%. The growth in the historic period can be attributed to the increasing prevalence of severe combined immunodeficiency, rising incidence of PID, growing prevalence of immunodeficiencies, increasing healthcare investments, and increasing awareness of immunodeficiencies.
The adenosine deaminase-severe combined immunodeficiency market size is expected to see strong growth in the next few years. It will grow to $7.64 billion in 2029 at a compound annual growth rate (CAGR) of 6.5%. The growth in the forecast period can be attributed to the rising prevalence of genetic disorders, rising usage of bone marrow transplantation, increasing demand for non-conditioned stem cell transplantation, increasing prevalence of ADA deficiency, and rising number of adenosine deaminase deficiency (PDA). Major trends in the forecast period include technological advancements, adoption of gene therapy, government initiatives, advanced genetic testing, and advances in biotechnology.
The forecast of 6.5% growth over the next five years reflects a slight reduction of 0.1% from the previous projection. This reduction is primarily due to the impact of tariffs between the US and other countries. Trade tensions could hinder U.S. pediatric care by inflating prices of enzyme replacement therapies and gene-editing components developed in Belgium and the Netherlands, resulting in prolonged immune deficiency risks and higher neonatal ICU costs. The effect will also be felt more widely due to reciprocal tariffs and the negative effect on the global economy and trade due to increased trade tensions and restrictions.
The increasing prevalence of genetic disorders is expected to drive the growth of the adenosine deaminase-severe combined immunodeficiency (ADA-SCID) market. Genetic disorders result from abnormalities or mutations in an individual's DNA, either inherited or occurring spontaneously. Factors such as advancements in diagnostic technologies, greater awareness, higher parental age, environmental influences, and population growth contribute to the rising prevalence of genetic conditions. In particular, the increasing occurrence of genetic disorders, including ADA-SCID, is fueling the demand for advanced diagnostic techniques and targeted treatments. For example, in December 2022, a report published by the Department of Health & Social Care (DHSC), a UK-based government department, revealed that as of October 2022, approximately 33,000 whole genome equivalents had been sequenced, with an average diagnostic yield of 32%, rising to 61% in specific conditions. Consequently, the growing prevalence of genetic disorders is propelling the expansion of the ADA-SCID market.
Leading companies in the ADA-SCID market are prioritizing the development of innovative treatments, such as gene therapy, to improve patient outcomes, enhance survival rates, and address the underlying genetic causes of the disorder using advanced medical technologies. Gene therapy for ADA-SCID aims to correct the genetic defect by introducing a functional copy of the ADA gene, potentially offering a long-term cure for this rare and life-threatening immune condition. For instance, in May 2022, Danaher Corporation, a US-based life sciences and diagnostics company, joined the Bespoke Gene Therapy Consortium (BGTC) as part of the Accelerating Medicines Partnership (AMP) program. This initiative, in collaboration with the U.S. Food and Drug Administration (FDA), the National Institutes of Health (NIH), pharmaceutical companies, and non-profit organizations, seeks to advance customized gene therapies for rare diseases and streamline their development. This collaboration is particularly important as it addresses the challenges of traditional drug development for rare diseases, which often receive limited commercial interest due to their low prevalence.
In January 2024, Kyowa Kirin Co., Ltd., a Japan-based pharmaceutical company, acquired Orchard Therapeutics plc. for an undisclosed amount. This acquisition enhances Kyowa Kirin's focus on developing innovative treatments for rare and complex diseases by leveraging Orchard Therapeutics' expertise in gene therapy. Orchard Therapeutics plc, a UK-based company, specializes in creating gene therapies for rare genetic disorders.
Major players in the adenosine deaminase-severe combined immunodeficiency market are Novartis AG, GlaxoSmithKline plc (GSK), Astellas Pharma, Orient EuroPharma, Charles River Laboratories, Chiesi Farmaceutici S.p.A., Spark Therapeutics, Rocket Pharmaceuticals, Bluebird Bio, Ospedale San Raffaele (OSR), Oxford Biomedica PLC, Teijin Pharma, Leadiant Biosciences, Orchard Therapeutics PLC, Fondazione Telethon, Mustang Bio Inc., Sigma-Tau Pharmaceuticals, Shenzhen Geno-Immune Medical Institute, ENZON Pharmaceuticals, and QED Bioscience Inc.
North America was the largest region in the adenosine deaminase-severe combined immunodeficiency market in 2024. The regions covered in adenosine deaminase-severe combined immunodeficiency report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.
The countries covered in the adenosine deaminase-severe combined immunodeficiency market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The adenosine deaminase-severe combined immunodeficiency market consists of revenues earned by entities by providing services such as diagnosis and genetic testing, therapy services, and consultation & genetic counseling. The market value includes the value of related goods sold by the service provider or included within the service offering. The adenosine deaminase-severe combined immunodeficiency market also includes sales of diagnostic tools, supportive therapies, and genetic testing kits. Values in this market are 'factory gate' values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Adenosine Deaminase-Severe Combined Immunodeficiency Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses on adenosine deaminase-severe combined immunodeficiency market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for adenosine deaminase-severe combined immunodeficiency ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward, including technological disruption, regulatory shifts, and changing consumer preferences? The adenosine deaminase-severe combined immunodeficiency market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
The forecasts are made after considering the major factors currently impacting the market. These include the technological advancements such as AI and automation, Russia-Ukraine war, trade tariffs (government-imposed import/export duties), elevated inflation and interest rates.