PUBLISHER: The Business Research Company | PRODUCT CODE: 1826927
PUBLISHER: The Business Research Company | PRODUCT CODE: 1826927
Gastroesophageal junction adenocarcinoma is a malignant tumor that forms at the junction of the esophagus and stomach, often linked to chronic acid reflux, obesity, and other risk factors. Its treatment options include targeted therapies, immunotherapy, chemotherapy, and surgical procedures designed to slow tumor progression, improve survival rates, and enhance patient outcomes.
The primary therapeutics for gastroesophageal junction adenocarcinoma include trastuzumab and ramucirumab. Trastuzumab is a targeted therapy drug used to treat HER2-positive gastroesophageal junction adenocarcinoma by blocking the HER2 protein, which contributes to cancer growth. Diagnosis is conducted through procedures such as endoscopy, X-ray, computed tomography (CT) scan, and positron emission tomography (PET) scan. Treatment approaches include esophagectomy surgery, esophageal dilation, chemotherapy, and targeted therapy. These therapeutics are distributed through hospital pharmacies, retail pharmacies, and online pharmacies.
Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report's Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.
The sharp rise in U.S. tariffs and the resulting trade tensions in spring 2025 are having a significant impact on the healthcare sector, especially in the supply of essential medical devices, diagnostic equipment, and pharmaceuticals. Hospitals and healthcare providers are grappling with higher costs for imported surgical tools, imaging systems, and consumables like syringes and catheters, many of which have limited domestic substitutes. These escalating expenses are putting pressure on healthcare budgets, prompting some providers to delay equipment upgrades or pass increased costs on to patients. Furthermore, tariffs on raw materials and components are disrupting the manufacturing of vital drugs and devices, leading to supply chain delays. In response, the industry is adopting diversified sourcing strategies, expanding local production where feasible, and pushing for tariff exemptions on critical medical products.
The gastroesophageal junction adenocarcinoma therapeutics market research report is one of a series of new reports from The Business Research Company that provides gastroesophageal junction adenocarcinoma therapeutics market statistics, including the gastroesophageal junction adenocarcinoma therapeutics industry global market size, regional shares, competitors with the gastroesophageal junction adenocarcinoma therapeutics market share, detailed gastroesophageal junction adenocarcinoma therapeutics market segments, market trends, and opportunities, and any further data you may need to thrive in the gastroesophageal junction adenocarcinoma therapeutics industry. This gastroesophageal junction adenocarcinoma therapeutics market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.
The gastroesophageal junction adenocarcinoma therapeutics market size has grown rapidly in recent years. It will grow from $3.85 billion in 2024 to $4.47 billion in 2025 at a compound annual growth rate (CAGR) of 16.1%. The growth in the historic period can be attributed to the increasing prevalence of helicobacter pylori infection, the increasing number of barrett's esophagus cases, the growing number of screening programs, the increasing research and development investment, and the rise in healthcare access.
The gastroesophageal junction adenocarcinoma therapeutics market size is expected to see rapid growth in the next few years. It will grow to $8.07 billion in 2029 at a compound annual growth rate (CAGR) of 16.0%. The growth in the forecast period can be attributed to a focus on precision oncology, a rise in multidisciplinary treatment approaches, a growing use of liquid biopsies, a shift toward minimally invasive procedures, and an increasing acceptance and use of immuno-oncology treatments. Major trends in the forecast period include the development of next-generation sequencing in clinical practice, innovations in targeted radiation therapy, advancements in molecular imaging, the integration of artificial intelligence in treatment planning, and advancements in surgical techniques.
The forecast of 16.0% growth over the next five years reflects a slight reduction of 0.2% from the previous projection. This reduction is primarily due to the impact of tariffs between the US and other countries. Tariff barriers are expected to increase costs for immune checkpoint inhibitors and HER2-targeted therapies sourced from Switzerland and Germany, delaying life-extending treatments for this aggressive cancer and raising oncology department expenses. The effect will also be felt more widely due to reciprocal tariffs and the negative effect on the global economy and trade due to increased trade tensions and restrictions.
The rising obesity rates are expected to drive the growth of the gastroesophageal junction adenocarcinoma (GEJA) therapeutics market. Obesity, a condition characterized by excessive body fat accumulation, is increasing due to factors such as poor dietary habits, sedentary lifestyles, lack of physical activity, and the consumption of processed and high-calorie foods. GEJA therapeutics play a crucial role in addressing the underlying mechanisms that contribute to weight gain, including inflammation, metabolic disruption, and hormonal imbalances, which can be exacerbated by the disease. For instance, in March 2024, the World Health Organization (WHO), a Switzerland-based intergovernmental organization, reported that approximately one in eight people worldwide were struggling with obesity. This included 2.5 billion adults classified as overweight, with 890 million of them living with obesity. Among adults, 43% were overweight, and 16% were classified as obese. Additionally, the number of overweight children under the age of 5 reached 37 million. Therefore, the growing obesity rates are fueling the expansion of the GEJA therapeutics market.
Leading companies in the GEJA therapeutics market are focused on developing innovative combination therapies to enhance treatment efficacy, improve patient outcomes, and address resistance to existing treatments. Combination therapy involves using two or more therapeutic agents, such as drugs or treatment modalities, to improve effectiveness and target multiple aspects of a disease simultaneously. For example, in October 2024, Astellas Pharma Inc., a Japan-based pharmaceutical company, received U.S. Food and Drug Administration (FDA) approval for zolbetuximab-clzb in combination with fluoropyrimidine- and platinum-containing chemotherapy. Zolbetuximab-clzb is a first-in-class monoclonal antibody specifically targeting Claudin 18.2, a protein highly expressed in gastric and GEJ cancers, thereby improving treatment precision and effectiveness. By selectively binding to CLDN18.2-expressing cancer cells, this therapy enables a targeted approach, minimizing damage to healthy tissues while optimizing therapeutic outcomes.
In January 2023, Leap Therapeutics Inc., a US-based biotech company, acquired Flame Biosciences Inc. for $115 million. This acquisition strengthens Leap Therapeutics' oncology pipeline by integrating innovative cancer therapies developed by Flame Biosciences, expanding its portfolio of targeted treatments, and advancing research efforts to develop cutting-edge solutions for GEJA and other cancers. Flame Biosciences Inc., a US-based company, specializes in developing therapeutics for gastroesophageal junction adenocarcinoma, further enhancing Leap Therapeutics' capabilities in this market.
Major players in the gastroesophageal junction adenocarcinoma therapeutics market are Pfizer Inc., F Hoffmann-La Roche AG, Merck & Co. Inc., Bristol-Myers Squibb Company, AstraZeneca plc, Teva Pharmaceutical Industries Ltd., Daiichi Sankyo Company Limited, Genentech Inc., Incyte Corporation, Ono Pharmaceutical Co. Ltd., BeiGene Ltd., Zymeworks Inc., Zai Lab Limited, ImmunoGen Inc., Elevar Therapeutics Inc., Mirati Therapeutics Inc., Shanghai Henlius Biotech Inc., Taiho Pharmaceutical Co. Ltd., LintonPharm Ltd., Celltrion Healthcare Co. Ltd.
North America was the largest region in the gastroesophageal junction adenocarcinoma therapeutics market in 2024. The regions covered in gastroesophageal junction adenocarcinoma therapeutics report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.
The countries covered in the gastroesophageal junction adenocarcinoma therapeutics market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The gastroesophageal junction adenocarcinoma therapeutics market includes revenues earned by entities by providing services such as radiation therapy, immunotherapy, surgical oncology, and palliative care and related products such as angiogenesis inhibitors, chemoradiation therapy, biosimilars, and combination therapies. The market value includes the value of related goods sold by the service provider or included within the service offering. Only goods and services traded between entities or sold to end consumers are included.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values and are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Gastroesophageal Junction Adenocarcinoma Therapeutics Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses on gastroesophageal junction adenocarcinoma therapeutics market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for gastroesophageal junction adenocarcinoma therapeutics ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward, including technological disruption, regulatory shifts, and changing consumer preferences? The gastroesophageal junction adenocarcinoma therapeutics market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
The forecasts are made after considering the major factors currently impacting the market. These include the technological advancements such as AI and automation, Russia-Ukraine war, trade tariffs (government-imposed import/export duties), elevated inflation and interest rates.