PUBLISHER: The Business Research Company | PRODUCT CODE: 1826938
PUBLISHER: The Business Research Company | PRODUCT CODE: 1826938
Heterozygous familial hypercholesterolemia (HeFH) management is a comprehensive strategy aimed at controlling elevated low-density lipoprotein cholesterol (LDL-C) levels in individuals with a genetic predisposition to high cholesterol. The goal is to lower the risk of premature cardiovascular disease (CVD) through lifestyle modifications, lipid-lowering medications, and, in certain cases, advanced treatments such as lipoprotein apheresis.
The primary treatment options for HeFH management include statins, ezetimibe, PCSK9 inhibitors, lomitapide, and mipomersen. Statins are a class of medications that lower cholesterol levels by inhibiting HMG-CoA reductase, a key enzyme in cholesterol production in the liver. The available routes of administration include oral, injectable, and intravenous. The treatment applies to various patient demographics, including children, adults, and the elderly, and is utilized in multiple healthcare settings such as hospitals, medical centers, clinics, and others.
Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report's Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.
The sharp rise in U.S. tariffs and the resulting trade tensions in spring 2025 are having a significant impact on the healthcare sector, especially in the supply of essential medical devices, diagnostic equipment, and pharmaceuticals. Hospitals and healthcare providers are grappling with higher costs for imported surgical tools, imaging systems, and consumables like syringes and catheters, many of which have limited domestic substitutes. These escalating expenses are putting pressure on healthcare budgets, prompting some providers to delay equipment upgrades or pass increased costs on to patients. Furthermore, tariffs on raw materials and components are disrupting the manufacturing of vital drugs and devices, leading to supply chain delays. In response, the industry is adopting diversified sourcing strategies, expanding local production where feasible, and pushing for tariff exemptions on critical medical products.
The heterozygous familial hypercholesterolemia management market research report is one of a series of new reports from The Business Research Company that provides heterozygous familial hypercholesterolemia management market statistics, including the heterozygous familial hypercholesterolemia management industry global market size, regional shares, competitors with the heterozygous familial hypercholesterolemia management market share, detailed heterozygous familial hypercholesterolemia management market segments, market trends, and opportunities, and any further data you may need to thrive in the heterozygous familial hypercholesterolemia management industry. This heterozygous familial hypercholesterolemia management market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.
The heterozygous familial hypercholesterolemia management market size has grown rapidly in recent years. It will grow from $10.84 billion in 2024 to $12.04 billion in 2025 at a compound annual growth rate (CAGR) of 11.0%. The growth in the historic period can be attributed to the rising prevalence of cardiovascular diseases, governmental initiatives, increasing investment in research and development activities, increasing awareness and diagnosis of Hefh, and growing demand for personalized therapies.
The heterozygous familial hypercholesterolemia management market size is expected to see rapid growth in the next few years. It will grow to $18.22 billion in 2029 at a compound annual growth rate (CAGR) of 10.9%. The growth in the forecast period can be attributed to the expansion of telehealth services, the prevalence of chronic illnesses, the increase in the number of clinical trials, the growing geriatric population, and the surge in the number of drugs in the pipeline. Major trends in the forecast period include the integration of digital health solutions, advancements in therapeutic options, the development of combination therapies, technological advancements, and the development of novel therapies.
The forecast of 10.9% growth over the next five years reflects a slight reduction of 0.2% from the previous projection. This reduction is primarily due to the impact of tariffs between the US and other countries. Trade tensions could hinder U.S. adoption of PCSK9 inhibitors by inflating prices of evolocumab and alirocumab developed in the U.S. and France, resulting in delayed LDL control and higher cardiology costs. The effect will also be felt more widely due to reciprocal tariffs and the negative effect on the global economy and trade due to increased trade tensions and restrictions.
The increasing prevalence of cardiovascular diseases is expected to drive the expansion of the heterozygous familial hypercholesterolemia management market. Cardiovascular diseases (CVDs) encompass a range of disorders affecting the heart and blood vessels, including coronary artery disease, heart failure, and stroke. The growing incidence of CVDs worldwide is linked to rising risk factors such as unhealthy diets, sedentary lifestyles, obesity, and an aging population. Effective management of heterozygous familial hypercholesterolemia plays a vital role in preventing cardiovascular diseases by controlling high cholesterol levels, a major risk factor for atherosclerosis and heart-related complications. For example, according to the Centers for Disease Control and Prevention (CDC), a US-based government agency, approximately 805,000 people in the United States suffered a heart attack in 2022, with 605,000 being first-time cases and 200,000 occurring in individuals with a previous history of heart attacks. As a result, the rising prevalence of cardiovascular diseases is fueling the growth of the heterozygous familial hypercholesterolemia management market.
Leading companies in the heterozygous familial hypercholesterolemia management market are focusing on developing innovative treatments, such as angiopoietin-based therapies, to improve lipid metabolism and lower cholesterol levels. Angiopoietins are a family of proteins that regulate blood vessel formation (angiogenesis) and maintain vascular stability. For instance, in March 2023, Regeneron Pharmaceuticals Inc., a US-based biotechnology company, received approval from the U.S. Food and Drug Administration (FDA) for Evkeeza (evinacumab-dgnb) for children aged 5 to 11 years with homozygous familial hypercholesterolemia (HoFH). This first-in-class monoclonal antibody works by inhibiting ANGPTL3, a protein that disrupts lipid metabolism, thereby reducing low-density lipoprotein (LDL) cholesterol and triglyceride levels. This approval provides a novel therapeutic option for pediatric patients with limited treatment alternatives and a high risk of cardiovascular events.
In February 2025, Tempus AI Inc., a US-based testing laboratory company, acquired Ambry Genetics for an undisclosed amount. This acquisition aims to enhance diagnostics and patient care by integrating artificial intelligence with genetic testing and expanding into new disease areas. Ambry Genetics Corporation, a US-based company, specializes in genetic testing for heterozygous familial hypercholesterolemia (HeFH).
Major players in the heterozygous familial hypercholesterolemia management market are Pfizer Inc., Johnson & Johnson, Roche Holding AG, Merck & Co. Inc., AbbVie Inc., Sanofi S.A., Bristol-Myers Squibb, AstraZeneca plc, Novartis International AG, Takeda Pharmaceutical Company Limited, Eli Lilly and Company, Gilead Sciences Inc., Amgen Inc., Merck KGaA, Regeneron Pharmaceuticals Inc., Ipsen S.A., Chiesi Farmaceutici S.p.A., Ferring Pharmaceuticals Limited, Esperion Therapeutics Inc., Aegerion Pharmaceuticals Inc., Verve Therapeutics Inc.
North America was the largest region in the heterozygous familial hypercholesterolemia management market in 2024. The regions covered in heterozygous familial hypercholesterolemia management report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.
The countries covered in the heterozygous familial hypercholesterolemia management market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The heterozygous familial hypercholesterolemia management market includes revenues earned by entities by providing services such as genetic testing and diagnosis, cholesterol monitoring, and lifestyle counseling. The market value includes the value of related goods sold by the service provider or included within the service offering. Only goods and services traded between entities or sold to end consumers are included.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Heterozygous Familial Hypercholesterolemia Management Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses on heterozygous familial hypercholesterolemia management market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for heterozygous familial hypercholesterolemia management ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward, including technological disruption, regulatory shifts, and changing consumer preferences? The heterozygous familial hypercholesterolemia management market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
The forecasts are made after considering the major factors currently impacting the market. These include the technological advancements such as AI and automation, Russia-Ukraine war, trade tariffs (government-imposed import/export duties), elevated inflation and interest rates.