Tangential flow filtration (TFF), also known as crossflow filtration, is a membrane-based separation technique where a liquid solution flows tangentially across the surface of a filter membrane. This method allows smaller molecules and solvents to pass through the membrane (permeate), while larger particles like proteins, cells, or other macromolecules are retained (retentate). The primary purpose of TFF is to concentrate, clarify, and purify biological products such as proteins, enzymes, antibodies, and cell cultures.
The tangential flow filtration market consists of sales, by entities (organizations, sole traders and partnerships), of tangential flow filtration that are used extensively in biopharmaceutical and diagnostic workflows. TFF is employed during downstream processing of biologics, vaccine manufacture, viral vector purification, cell-therapy operations and academic research. This technique offers high throughput, scalability, gentle processing and reduced fouling compared to dead-end filtration.
The global tangential flow filtration market was valued at $1,134.66 million in 2019 which grew till 2024 at a compound annual growth rate (CAGR) of more than 12.00%.
Rising R&D Spending in Life Sciences
During the historic period, the rising R&D (Research and Development) spending in life sciences supported the growth of the tangential flow filtration market. Rising R&D spending in pharma and biotech is accelerating the development of biologics and advanced therapies, driving demand for scalable, GMP (Good Manufacturing Practice) -compliant purification technologies. TFF is essential for ultrafiltration and diafiltration of sensitive biologics, offering gentle, sterile processing from lab to commercial scale. Its role is especially critical in clinical-grade drug production and in the purification of gene therapies, cell therapies and mRNA vaccines, where product integrity must be maintained. For instance, in July 2024, according to the GOV.UK, a UK-based government department, in 2022, the business enterprise sector conducted £9.0 billion ($11.7 billion) in pharmaceutical R&D, representing 0.36% of the UK's GDP. Pharmaceutical R&D made up 18% of all R&D carried out by businesses in the UK, the highest percentage among all product areas. Therefore, the rising R&D spending on life sciences drove the growth of the TFF market.
Strategic Acquisitions Drive Expansion in the Tangential Flow Filtration Market
Companies in the TFF market are increasingly adopting strategic acquisitions as a key approach to business expansion. These acquisitions allow organizations to leverage each other's strengths, expand their geographic footprint and enhance their service offerings. For example, in February 2025, Thermo Fisher Scientific, a US-based company specializing in life sciences, acquired Solventum $4.1 billion. This acquisition is designed to strengthen Thermo Fisher's bioproduction capabilities, particularly in supporting biologics and advanced therapies. By integrating Solventum's membrane technologies and critical filtration media-including TFF-Thermo Fisher will enhance both upstream and downstream bioprocessing workflows. The acquisition is highly complementary to Thermo Fisher's existing portfolio in cell culture media and single-use technologies, expanding its ability to serve the rapidly growing market for biologics production. Solventum is a US-based company that provides TFF as part of its bioprocessing solutions.
The global tangential flow filtration market is fairly concentrated, with large players operating in the market. The top 10 competitors in the market made up 32.13% of the total market in 2023.
Tangential Flow Filtration Global Market Opportunities And Strategies To 2034 from The Business Research Company provides the strategists; marketers and senior management with the critical information they need to assess the global tangential flow filtration market as it emerges from the COVID-19 shut down.
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Where is the largest and fastest-growing market for tangential flow filtration? How does the market relate to the overall economy; demography and other similar markets? What forces will shape the market going forward? The tangential flow filtration market global report from The Business Research Company answers all these questions and many more.
The report covers market characteristics; size and growth; segmentation; regional and country breakdowns; competitive landscape; market shares; trends and strategies for this market. It traces the market's history and forecasts market growth by geography. It places the market within the context of the wider tangential flow filtration market; and compares it with other markets.
The report covers the following chapters
- Introduction And Market Characteristics- Brief introduction to the segmentations covered in the market, definitions and explanations about the segment by product, by technology and by application.
- Key Trends- Highlights the major trends shaping the global market. This section also highlights likely future developments in the market.
- Growth Analysis And Strategic Analysis Framework- Analysis on PESTEL, end use industries, market growth rate, global historic (2019-2024) and forecast (2024-2029, 2034F) market values and drivers and restraints that support and control the growth of the market in the historic and forecast periods, forecast growth contributors and total addressable market (TAM).
- Global Market Size And Growth- Global historic (2019-2024) and forecast (2024-2029, 2034F) market values and drivers and restraints that support and control the growth of the market in the historic and forecast periods.
- Regional And Country Analysis- Historic (2019-2024) and forecast (2024-2029, 2034F) market values and growth and market share comparison by region and country.
- Market Segmentation- Contains the market values (2019-2024) (2024-2029, 2034F) and analysis for each segment by product, by technology and by application in the market. Historic (2019-2024) and forecast (2024-2029) and (2029-2034) market values and growth and market share comparison by region market.
- Regional Market Size And Growth- Regional market size (2024), historic (2019-2024) and forecast (2024-2029, 2034F) market values and growth and market share comparison of countries within the region. This report includes information on all the regions Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa and major countries within each region.
- Competitive Landscape- Details on the competitive landscape of the market, estimated market shares and company profiles of the leading players.
- Other Major And Innovative Companies- Details on the company profiles of other major and innovative companies in the market.
- Competitive Benchmarking- Briefs on the financials comparison between major players in the market.
- Competitive Dashboard- Briefs on competitive dashboard of major players.
- Key Mergers And Acquisitions- Information on recent mergers and acquisitions in the market covered in the report. This section gives key financial details of mergers and acquisitions, which have shaped the market in recent years.
- Recent Developments- Information on recent developments in the market covered in the report.
- Market Opportunities And Strategies- Describes market opportunities and strategies based on findings of the research, with information on growth opportunities across countries, segments and strategies to be followed in those markets.
- Conclusions And Recommendations- This section includes recommendations for tangential flow filtration market providers in terms of product/service offerings geographic expansion, marketing strategies and target groups.
- Appendix- This section includes details on the NAICS codes covered, abbreviations and currencies codes used in this report.
Markets Covered:
- 1) By Product: Reusable Systems; Single-Use Systems; Membrane Filters; Filtration Accessories
- 2) By Technology: Ultrafiltration; Microfiltration; Reverse Osmosis; Nanofiltration
- 3) By Application: Bioprocess Applications; Viral Vector And Vaccine Purification; Other Applications
- Companies Mentioned: Danaher Corporation (Pall Corporation); Merck KGaA (Millipore); Sartorius AG; Repligen Corporation; Parker Hannifin Corporation
- Countries: China; Australia; India; Indonesia; Japan; South Korea; USA; Canada; Brazil; France; Germany; UK; Italy; Spain; Russia
- Regions: Asia-Pacific; Western Europe; Eastern Europe; North America; South America; Middle East; Africa
- Time-series: Five years historic and ten years forecast.
- Data: Ratios of market size and growth to related markets; GDP proportions; expenditure per capita; tangential flow filtration indicators comparison.
- Data segmentations: country and regional historic and forecast data; market share of competitors; market segments.
- Sourcing and Referencing: Data and analysis throughout the report is sourced using end notes.