PUBLISHER: The Business Research Company | PRODUCT CODE: 1833956
PUBLISHER: The Business Research Company | PRODUCT CODE: 1833956
Metabolic dysfunction-associated steatohepatitis (MASH), previously known as non-alcoholic steatohepatitis (NASH), is a chronic and progressive liver disease characterized by fat accumulation, inflammation and fibrosis in the liver, primarily linked to obesity, insulin resistance, type 2 diabetes and other metabolic disorders. The primary purpose of metabolic dysfunction-associated steatohepatitis (MASH) treatment is to halt or reverse liver damage, prevent disease progression to cirrhosis or liver failure, and manage associated metabolic conditions. The treatment typically includes lifestyle interventions, pharmacotherapy, and in some cases, surgical options to reduce liver inflammation, fibrosis, and metabolic risk factors.
The MASH treatment market consists of sales by entities (organizations, sole traders and partnerships) of MASH treatment drugs and therapy that is used when lifestyle modifications alone are insufficient to halt or reverse liver damage. It is utilized across a continuum of care, beginning with non-invasive interventions and progressing to pharmacological treatment or bariatric surgery in advanced cases.
The global MASH treatment market was valued at $978.91 million in 2019 which grew till 2024 at a compound annual growth rate (CAGR) of more than 21.00%.
Rising Research And Development (R&D) Spending In Life Sciences
Rising research and development (R&D) spending in life sciences fueled the growth of the MASH treatment in the historic period. MASH, a progressive liver disease linked to metabolic disorders like obesity and diabetes, has seen a surge in prevalence globally, driving pharmaceutical and biotech firms to invest heavily in novel therapeutics. Enhanced R&D funding has enabled breakthroughs in understanding disease mechanisms, such as lipid metabolism dysregulation, inflammation and fibrosis, leading to targeted drug development. Innovations in biomarkers, genetic research and preclinical models have accelerated drug discovery, while clinical trials for promising candidates like FXR agonists, THR-B agonists and GLP-1 receptor agonists have expanded. For instance, in July 2024, according to the GOV.UK, a UK-based government department, in 2022, the business enterprise sector conducted £9.0 billion ($11.7 billion) in pharmaceutical R&D, representing 0.36% of the UK's GDP. Pharmaceutical R&D made up 18% of all R&D carried out by businesses in the UK, the highest percentage among all product areas. Therefore, the rising research and development (R&D) spending in life sciences drove the growth of the MASH treatment market.
Advancements In Fibroblast Growth Factors (FGFs) Through Acquisitions
Major companies operating in the MASH treatment market are focusing on advancing fibroblast growth factor to strengthen their market position. Fibroblast growth factor 21 (FGF21) is a hormone-like protein that regulates lipid, glucose and energy metabolism in the body. FGF21 analogs have shown promise by reducing liver fat, inflammation and fibrosis, thus improving liver health and helping to resolve MASH without worsening fibrosis. These effects make FGF21-based therapies a leading strategy for addressing the metabolic and fibrotic complications of MASH. For example, in May 2025, GlaxoSmithKline (GSK), a UK-based pharma company acquired Efimosfermin (also known as efimosfermin alfa), a once-monthly fibroblast growth factor 21 (FGF21) from Boston Pharmaceuticals, a US-based pharma company. Efimosfermin is designed to provide direct antifibrotic action, aiming to reverse liver fibrosis and halt the progression of Metabolic Dysfunction-Associated Steatohepatitis (MASH), including cases that have advanced to cirrhosis. In addition to MASH, the therapy is being developed for alcohol-related liver disease (ALD) and both forms of steatotic liver disease (SLD), broadening its potential impact on serious liver conditions. GSK plans to explore efimosfermin both as a monotherapy and in combination with other investigational agents, including their siRNA therapeutic for liver disease. The acquisition and development of efimosfermin position GSK as a significant player in the evolving market for innovative liver disease therapies.
The global MASH treatment markets is fragmented, with large number of players operating in the market. The top 10 competitors in the market made up 9.15% of the total market in 2024.
MASH Treatment Global Market Opportunities and Strategies To 2034 from The Business Research Company provides the strategists; marketers and senior management with the critical information they need to assess the global MASH treatment market as it emerges from the COVID-19 shut down.
Where is the largest and fastest-growing market for MASH treatment? How does the market relate to the overall economy; demography and other similar markets? What forces will shape the market going forward? The MASH treatment market global report from The Business Research Company answers all these questions and many more.
The report covers market characteristics; size and growth; segmentation; regional and country breakdowns; competitive landscape; market shares; trends and strategies for this market. It traces the market's history and forecasts market growth by geography. It places the market within the context of the wider MASH treatment market; and compares it with other markets.