PUBLISHER: The Business Research Company | PRODUCT CODE: 1889578
PUBLISHER: The Business Research Company | PRODUCT CODE: 1889578
Small interfering ribonucleic acid (RNA) is a short, double stranded RNA molecule that plays a key role in gene silencing through a process called RNA interference (RNAi). It binds to complementary messenger RNA (mRNA) sequences, causing their degradation and preventing protein synthesis. The primary purpose of siRNA is to regulate or suppress the expression of specific genes, and it is often used in research and therapeutic applications to target disease causing genes.
The main types of small interfering ribonucleic acid (RNA) include liposome systemic therapy and nanoparticle based systemic therapy. Liposome systemic therapy is a drug delivery method that uses liposomes to carry therapeutic agents throughout the body via the bloodstream. These therapies are indicated for conditions such as cardiovascular diseases, respiratory diseases, oncology, neurodegenerative diseases, and infectious diseases, serving end users such as hospitals, research institutions, pharmaceutical and biotechnology companies, and academic institutions.
Note that the outlook for this market is being affected by rapid changes in trade relations and tariffs globally. The report will be updated prior to delivery to reflect the latest status, including revised forecasts and quantified impact analysis. The report's Recommendations and Conclusions sections will be updated to give strategies for entities dealing with the fast-moving international environment.
The sudden escalation of U.S. tariffs and the consequent trade frictions in spring 2025 are severely impacting the pharmaceutical companies contend with tariffs on APIs, glass vials, and lab equipment inputs with few alternative sources. Generic drug makers, operating on razor-thin margins, are especially vulnerable, with some reducing production of low-profit medicines. Biotech firms face delays in clinical trials due to tariff-related shortages of specialized reagents. In response, the industry is expanding API production in India and Europe, increasing inventory stockpiles, and pushing for trade exemptions for essential medicines.
The small interfering ribonucleic acid (RNA) market research report is one of a series of new reports from the business research company that provides small interfering ribonucleic acid (RNA) market statistics, including small interfering ribonucleic acid (RNA) industry global market size, regional shares, competitors with a small interfering ribonucleic acid (RNA) market share, detailed small interfering ribonucleic acid (RNA) market segments, market trends and opportunities, and any further data you may need to thrive in the small interfering ribonucleic acid (RNA) industry. This small interfering ribonucleic acid (RNA) market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The small interfering ribonucleic acid (RNA) market size has grown exponentially in recent years. It will grow from $15.65 billion in 2024 to $18.86 billion in 2025 at a compound annual growth rate (CAGR) of 20.5%. The growth in the historic period can be attributed to rising government funding, increasing awareness of genetic disorders, growing clinical trials for small interfering ribonucleic acid (siRNA) therapies, expansion of biotechnology infrastructure, and rising adoption of targeted therapeutics. biotechnology infrastructure, and increasing adoption of targeted therapeutics.
The small interfering ribonucleic acid (RNA) market size is expected to see exponential growth in the next few years. It will grow to $39.26 billion in 2029 at a compound annual growth rate (CAGR) of 20.1%. The growth in the forecast period can be attributed to rising demand for personalized medicine, growing investment in small interfering ribonucleic acid (siRNA) research, increasing collaborations between pharma companies, and rising approvals of small interfering ribonucleic acid (siRNA) based drugs. Major trends in the forecast period include technological advancements in delivery methods, innovations in RNAi therapeutics, developments in lipid nanoparticle carriers, research and development in gene silencing, and advancements in targeted drug delivery systems.
The rising demand for personalized medicine is expected to drive the growth of the small interfering ribonucleic acid (RNA) market in the coming years. Personalized medicine is an approach that tailors treatments to individual patients based on their genetic, environmental, and lifestyle factors to optimize outcomes and improve care. Demand is increasing due to advancements in genomic technologies, which allow precise identification of genetic variations and enable customized treatments for individuals. Small interfering ribonucleic acid (siRNA) supports personalized medicine by enabling targeted gene silencing, making it suitable for treating specific genetic disorders and diseases. It minimizes off-target effects by selectively inhibiting disease-causing mRNA, enhancing therapeutic efficacy and patient outcomes. For example, in February 2024, according to the Personalized Medicine Coalition, a US based nonprofit organization, the U.S. Food and Drug Administration approved 26 new personalized medicines in 2023, a notable increase from 12 approvals in 2022. Therefore, the growing demand for personalized medicine is driving the expansion of the small interfering ribonucleic acid (RNA) market.
Major companies in the small interfering ribonucleic acid (siRNA) therapeutics market are pursuing regulatory approvals for novel mechanisms to treat rare genetic diseases, aiming to provide sustained effects and reduce dosing frequency for patients. Regulatory approvals are official clearances that permit a therapy to be safely tested, marketed, or used in patients. For instance, in March 2025, Alnylam Pharmaceuticals Inc., a US based biopharmaceutical company, received approval from the U.S. Food and Drug Administration for Qfitlia (fitusiran), the first siRNA-based therapy for adults and adolescents aged 12 years and older with hemophilia A or B, with or without inhibitors. The therapy is designed to lower antithrombin levels, enhancing thrombin generation to promote clot formation and reduce bleeding episodes. Qfitlia provides a subcutaneous, once-every-two-month dosing regimen, offering a novel, non-factor therapeutic option for hemophilia management.
In May 2025, AbbVie Inc., a US based biopharmaceutical company, partnered with ADARx Pharmaceuticals Inc. Through this partnership, AbbVie aims to combine ADARx's proprietary RNA technology with its scientific expertise to develop next-generation siRNA therapies, advancing treatment in neuroscience, immunology, and oncology. ADARx Pharmaceuticals Inc. is a biotechnology company developing siRNA-based therapies that target specific mRNA to treat diseases.
Major companies operating in the small interfering ribonucleic acid (rna) market are Novartis AG, Thermo Fisher Scientific Inc., GlaxoSmithKline plc, Sanofi S.A., Sarepta Therapeutics Inc., Alnylam Pharmaceuticals Inc., Ionis Pharmaceuticals Inc., Wave Life Sciences Ltd., Silence Therapeutics plc, Arrowhead Pharmaceuticals Inc., Quark Pharmaceuticals Inc., Arbutus Biopharma Corporation, Evox Therapeutics Ltd., Phio Pharmaceuticals Inc., Genecon Biotechnologies Co., Ltd., Olix Pharmaceuticals, Inc., Benitec Biopharma Ltd., Bio-Path Holdings, Inc., Calando Pharmaceuticals, Inc., Sirnaomics, Ltd.
North America was the largest region in the small interfering ribonucleic acid (RNA) market in 2024. The regions covered in small interfering ribonucleic acid (RNA) report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.
The countries covered in the small interfering ribonucleic acid (RNA) market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The small interfering ribonucleic acid (RNA) market consists of revenues earned by entities by providing services such as gene silencing assays, delivery system development, molecular diagnostics, preclinical testing, and laboratory research support. The market value includes the value of related goods sold by the service provider or included within the service offering. The small interfering ribonucleic acid (RNA) market also includes sales of synthesis kits, lipid nanoparticles, delivery vectors, RNAi assay kits, transfection reagents, and RNA extraction kits. Values in this market are 'factory gate' values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Small Interfering Ribonucleic Acid (RNA) Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses on small interfering ribonucleic acid (rna) market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for small interfering ribonucleic acid (rna) ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward, including technological disruption, regulatory shifts, and changing consumer preferences? The small interfering ribonucleic acid (rna) market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
The forecasts are made after considering the major factors currently impacting the market. These include the technological advancements such as AI and automation, Russia-Ukraine war, trade tariffs (government-imposed import/export duties), elevated inflation and interest rates.