PUBLISHER: The Business Research Company | PRODUCT CODE: 1949667
PUBLISHER: The Business Research Company | PRODUCT CODE: 1949667
Next-generation complement therapeutics are advanced treatments designed to precisely modulate the complement system, a critical component of the immune response. These therapies employ innovative strategies, including antibody-based therapies, RNA medicines, and gene editing, to target complex immune and inflammatory disorders more effectively while minimizing side effects compared with traditional treatments.
The main types of next-generation complement therapeutics are monotherapy and adjunctive therapy. Monotherapy involves using a complement-targeted drug alone without combining it with other treatments. These therapies include various molecule types, such as biologics and small molecules, and are administered via multiple routes, including intravenous, oral, intravitreal, and subcutaneous. They target a wide range of indications, including paroxysmal nocturnal hemoglobinuria (PNH), geographic atrophy (GA) secondary to age-related macular degeneration, generalized myasthenia gravis, atypical hemolytic uremic syndrome (aHUS), and others, across therapeutic areas such as hematology, ophthalmology, neurology, immunology, and rheumatology.
Tariffs have affected the next-generation complement therapeutics market by increasing the cost of imported biologics, small molecules, and advanced delivery systems. Segments like monotherapy, adjunctive therapy, and RNA-based therapeutics are most impacted, particularly in regions such as North America and Europe that rely heavily on imports. While tariffs have raised production costs and slowed supply chains, they have also driven local manufacturing initiatives, innovation in drug formulation, and development of cost-effective domestic therapeutic options.
The next generation complement therapeutics market research report is one of a series of new reports from The Business Research Company that provides next generation complement therapeutics market statistics, including next generation complement therapeutics industry global market size, regional shares, competitors with a next generation complement therapeutics market share, detailed next generation complement therapeutics market segments, market trends and opportunities, and any further data you may need to thrive in the next generation complement therapeutics industry. This next generation complement therapeutics market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The next generation complement therapeutics market size has grown rapidly in recent years. It will grow from $7.38 billion in 2025 to $8.56 billion in 2026 at a compound annual growth rate (CAGR) of 16.0%. The growth in the historic period can be attributed to limited availability of complement-targeting therapeutics, reliance on conventional immunosuppressive therapies, growing prevalence of rare hematologic and autoimmune disorders, regulatory approvals for first-generation complement inhibitors, increasing clinical trials in hematology and ophthalmology.
The next generation complement therapeutics market size is expected to see rapid growth in the next few years. It will grow to $15.29 billion in 2030 at a compound annual growth rate (CAGR) of 15.6%. The growth in the forecast period can be attributed to development of novel c3, c5, factor b and factor d inhibitors, expansion of combination therapy approaches, rising adoption of gene and rna-based medicines, increasing investment in rare disease research, growing healthcare expenditure on advanced immune therapies. Major trends in the forecast period include rising adoption of targeted complement therapies for rare diseases, growth in monotherapy and adjunctive therapy approaches, increasing use of biologics and small molecule complement inhibitors, expansion of ophthalmology, hematology, and immunology applications, integration of personalized medicine and gene-based therapeutics.
The rising prevalence of chronic diseases is expected to propel the growth of the next-generation complement therapeutics market going forward. Chronic diseases are long-lasting health conditions that require ongoing management to control symptoms and improve quality of life. The increase in chronic diseases is driven by sedentary lifestyles, which reduce physical activity, disrupt metabolism, and elevate long-term health risks. Next-generation complement therapeutics address these conditions by precisely targeting and modulating the overactive complement system, reducing inflammation and preventing tissue damage. For instance, in June 2024, according to the National Health Service, a UK-based government department, 3,615,330 individuals registered with a general practitioner (GP) were diagnosed with non-diabetic hyperglycemia or pre-diabetes (elevated blood sugar levels not yet classified as diabetes) in 2023, reflecting an 18% increase from 3,065,825 cases in 2022. Therefore, the rise in chronic diseases is driving the growth of the next-generation complement therapeutics market.
Major companies operating in the next-generation complement therapeutics market are focusing on developing innovative solutions, such as targeted C5 complement inhibitors, to meet the growing demand for effective treatments for rare and severe complement-mediated diseases. Targeted C5 complement inhibitors are designed to selectively block the C5 protein in the complement cascade, preventing the formation of the membrane attack complex-a key contributor to immune-mediated tissue damage. For instance, in February 2024, Chugai Pharmaceutical Co., Ltd., a Japan-based biopharmaceutical company, launched PEGPH20 (Pegcetacoplan), a novel C5-targeted complement inhibitor. PEGPH20 is a synthetic peptide conjugate that selectively inhibits complement C5 activation, preventing hemolysis and inflammation associated with conditions such as paroxysmal nocturnal hemoglobinuria (PNH) and other complement-driven disorders. The therapy offers benefits including subcutaneous administration, improved patient compliance, and a favorable safety profile compared to traditional systemic complement inhibitors.
In March 2023, Pharmaron Inc., a China-based healthcare technology company, partnered with Complement Therapeutics Inc. to accelerate the development of complement-targeted therapies. Through this partnership, Pharmaron and Complement Therapeutics aim to enhance efficiency, data quality, and time-to-market for novel therapeutics by combining Pharmaron's integrated preclinical and clinical R&D capabilities with Complement's drug discovery expertise, supporting the development of innovative treatments for rare and autoimmune diseases. Complement Therapeutics Inc. is a US-based biotechnology company specializing in therapies targeting the complement system for rare and autoimmune conditions.
Major companies operating in the next generation complement therapeutics market are AstraZeneca PLC, Novartis AG, Amgen Inc., Regeneron Pharmaceuticals Inc., Genentech Inc., Genmab A/S, Mallinckrodt Pharmaceuticals Ltd., Alnylam Pharmaceuticals Inc., Apellis Pharmaceuticals Inc., Omeros Corporation, CANbridge Pharmaceuticals Inc., Alexion Pharmaceuticals Inc., Molecular Partners AG, NovelMed Therapeutics Inc., InflaRx GmbH, Amyndas Pharmaceuticals S.A., Kira Pharmaceuticals Inc., ReAlta Life Sciences Inc.
North America was the largest region in the next generation complement therapeutics market in 2025. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the next generation complement therapeutics market report are Asia-Pacific, South East Asia, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
The countries covered in the next generation complement therapeutics market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Taiwan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The next-generation complement therapeutics market consists of revenues earned by entities by providing services such as antibody engineering services, preclinical research services, biomanufacturing services, clinical trial management services, and regulatory consulting services. The market value includes the value of related goods sold by the service provider or included within the service offering. The next-generation complement therapeutics market also includes sales of monoclonal antibodies, gene editing tools, small molecule inhibitors, recombinant proteins, and fusion proteins. Values in this market are 'factory gate' values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Next Generation Complement Therapeutics Market Global Report 2026 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses next generation complement therapeutics market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for next generation complement therapeutics ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward, including technological disruption, regulatory shifts, and changing consumer preferences? The next generation complement therapeutics market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, total addressable market (TAM), market attractiveness score (MAS), competitive landscape, market shares, company scoring matrix, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
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