PUBLISHER: The Business Research Company | PRODUCT CODE: 1951612
PUBLISHER: The Business Research Company | PRODUCT CODE: 1951612
Chimeric antigen receptor-natural killer (CAR-NK) cell therapy is an advanced immunotherapy that genetically modifies natural killer (NK) cells with chimeric antigen receptors (CARs) to enhance their ability to recognize and destroy cancer cells. It is used for treating hematologic malignancies, solid tumors, and certain viral infections, offering advantages such as a lower risk of cytokine release syndrome (CRS), reduced potential for graft-versus-host disease (GvHD), and suitability for allogeneic (off-the-shelf) applications.
The main types of CAR-NK cell therapy include cytokine therapy, adoptive NK cell therapy, genetically engineered NK cell therapy, and others. Cytokine therapy involves the use of signaling proteins, such as interferons or interleukins, to modulate the immune system-either to stimulate anti-tumor activity or suppress harmful inflammation in autoimmune conditions. The various cell sources include peripheral blood-derived NK cells, cord blood-derived NK cells, induced pluripotent stem cell (iPSC)-derived NK cells, and NK cell lines. These therapies are applied in areas such as solid tumors, hematologic malignancies, and others, and are utilized by end users including hospitals, cancer research institutes, and biotechnology and pharmaceutical companies.
Tariffs have impacted the CAR-NK cell therapy market by increasing the cost of imported laboratory equipment, gene-editing tools, and cell culture reagents, which has disrupted the supply chain and slowed therapy production. Segments like genetically engineered NK cell therapies and cytokine-modified therapies are most affected, particularly in North America and Europe, which rely on imports for specialized materials. On the positive side, tariffs have encouraged local manufacturing, investment in domestic biomanufacturing facilities, and innovation in cost-efficient CAR-NK cell therapy solutions.
The chimeric antigen receptor-natural killer (car-nk) cell therapy market research report is one of a series of new reports from The Business Research Company that provides chimeric antigen receptor-natural killer (car-nk) cell therapy market statistics, including chimeric antigen receptor-natural killer (car-nk) cell therapy industry global market size, regional shares, competitors with a chimeric antigen receptor-natural killer (car-nk) cell therapy market share, detailed chimeric antigen receptor-natural killer (car-nk) cell therapy market segments, market trends and opportunities, and any further data you may need to thrive in the chimeric antigen receptor-natural killer (car-nk) cell therapy industry. This chimeric antigen receptor-natural killer (car-nk) cell therapy market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The chimeric antigen receptor-natural killer (car-nk) cell therapy market size has grown strongly in recent years. It will grow from $2.42 billion in 2025 to $2.58 billion in 2026 at a compound annual growth rate (CAGR) of 6.6%. The growth in the historic period can be attributed to limited availability of car-nk therapies, reliance on autologous nk cell therapy, growing incidence of hematologic cancers, increasing oncology research activities, regulatory approvals for early-generation nk cell therapies.
The chimeric antigen receptor-natural killer (car-nk) cell therapy market size is expected to see strong growth in the next few years. It will grow to $3.28 billion in 2030 at a compound annual growth rate (CAGR) of 6.2%. The growth in the forecast period can be attributed to development of genetically engineered car-nk cells, expansion of off-the-shelf therapies, rising adoption of cytokine and t cell receptor modified nk cells, increasing funding for clinical trials, integration of ai and big data in therapy optimization. Major trends in the forecast period include growth in allogeneic (off-the-shelf) car-nk cell therapies, expansion of hematological malignancy and solid tumor applications, integration of gene editing and cytokine gene modification techniques, increasing adoption of combination and immune checkpoint therapies, rising investment in clinical trials and oncology research programs.
The rising incidence of cancer worldwide is expected to drive the growth of the chimeric antigen receptor-natural killer (CAR-NK) cell therapy market in the coming years. Cancer encompasses a group of diseases characterized by the uncontrolled proliferation and spread of abnormal cells that can invade and damage body tissues. The rising incidence of cancer is attributed to factors such as aging populations and unhealthy lifestyles, as older age increases the accumulation of mutations over time, and habits like smoking, poor diet, and physical inactivity elevate cancer risk. CAR-NK cell therapy supports cancer treatment by engineering natural killer cells to specifically recognize and eliminate cancer cells, enhancing the immune system's targeted attack on tumors. For instance, in February 2024, the World Health Organization (WHO), a Switzerland-based intergovernmental organization, estimated that the 20 million new cancer cases reported in 2022 are projected to increase by 77% to over 35 million cases by 2050. Therefore, the rising incidence of cancer worldwide is propelling the growth of the CAR-NK cell therapy market.
Major companies in the CAR-NK cell therapy market are focusing on developing innovative approaches such as conditioning chemotherapy-free treatments to create safer and more effective off-the-shelf cellular therapies. Conditioning chemotherapy-free treatment eliminates the need for intensive pre-treatment chemotherapy to suppress the patient's immune system before administering cellular therapies, thereby reducing toxicity and adverse effects. For example, in November 2024, Fate Therapeutics Inc., a US-based clinical-stage biopharmaceutical company, launched FT522, an off-the-shelf CD19-targeted CAR NK cell therapy. This therapy integrates alloimmune defense receptor technology, allowing CAR NK cells to persist and selectively target pathogenic B cells in patients with relapsed or refractory B-cell lymphoma and autoimmune diseases, demonstrating promising safety and efficacy in early-phase clinical trials without requiring intensive immune suppression.
In April 2023, NKGen Biotech, a US-based biopharmaceutical company, merged with Graf Acquisition Corp. IV to become a publicly listed entity and advance its clinical development programs. Through this merger, NKGen Biotech aims to secure funding, leverage the combined expertise and resources of both organizations, accelerate innovation, expand its therapeutic pipeline, and bring transformative treatments for neurodegenerative and autoimmune diseases to patients more efficiently. Graf Acquisition Corp. IV is a US-based publicly listed special purpose acquisition company (SPAC) focused on partnering with growth-stage life sciences companies.
Major companies operating in the chimeric antigen receptor-natural killer (car-nk) cell therapy market are Artiva Biotherapeutics Inc., Nkarta Inc., Fate Therapeutics Inc., Acepodia Inc., Cartherics Inc., Century Therapeutics Inc., Catamaran Bio Inc., Glycostem Therapeutics Ltd., ImmuneBridge Co. Ltd., ONK Therapeutics Inc., Senti Biosciences Inc., Wugen Therapeutics Inc., Chimeric Therapeutics Limited, Nuwacell Biotechnologies Co. Ltd., Nkarta Therapeutics Inc., GICELL Co. Ltd.
North America was the largest region in the chimeric antigen receptor-natural killer (CAR-NK) cell therapy market in 2025. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the chimeric antigen receptor-natural killer (car-nk) cell therapy market report are Asia-Pacific, South East Asia, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
The countries covered in the chimeric antigen receptor-natural killer (car-nk) cell therapy market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Taiwan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The chimeric antigen receptor-natural killer (CAR-NK) cell therapy market includes revenues earned by entities through the research and development, clinical trial management, cell manufacturing, personalized treatment planning, and post-therapy patient monitoring. The market value includes the value of related goods sold by the service provider or included within the service offering. Only goods and services traded between entities or sold to end consumers are included.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Chimeric Antigen Receptor-Natural Killer (CAR-NK) Cell Therapy Market Global Report 2026 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses chimeric antigen receptor-natural killer (car-nk) cell therapy market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for chimeric antigen receptor-natural killer (car-nk) cell therapy ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward, including technological disruption, regulatory shifts, and changing consumer preferences? The chimeric antigen receptor-natural killer (car-nk) cell therapy market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, total addressable market (TAM), market attractiveness score (MAS), competitive landscape, market shares, company scoring matrix, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
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