PUBLISHER: The Business Research Company | PRODUCT CODE: 1951680
PUBLISHER: The Business Research Company | PRODUCT CODE: 1951680
Cytokine-based therapies and inhibitors are medical treatments that either stimulate or inhibit the activity of cytokines, which are small proteins responsible for regulating immune responses, inflammation, and cell-to-cell communication. These therapies are applied in the treatment of various conditions, including cancer, autoimmune diseases, and inflammatory disorders, by modulating immune system functions.
The main types of cytokine-based therapies and inhibitors include interleukins, tumor necrosis factor, epidermal growth factor, interferons, and chemokines. Interleukins are cytokine proteins produced by immune cells that play a key role in controlling immune responses, inflammation, and cellular signaling. These therapies are used across a range of applications such as cancer and malignancies, inflammatory and immune disorders, infectious diseases, asthma and airway inflammation, and other conditions. They are utilized by diverse end users, including hospitals, clinics, research laboratories, academic and research institutes, specialty centers, and others.
Tariffs have impacted the cytokine-based therapies and inhibitors market by increasing costs for imported raw materials, bioreactors, and specialized reagents used in manufacturing biologics. Segments such as interleukins and tumor necrosis factor inhibitors are particularly affected, with regions like North America and Asia-Pacific facing higher import duties. This has led to increased production costs and supply chain adjustments. Positively, tariffs are encouraging local manufacturing, technology innovation, and the development of domestic biologics production capacities.
The cytokine-based therapies and inhibitors market research report is one of a series of new reports from The Business Research Company that provides cytokine-based therapies and inhibitors market statistics, including cytokine-based therapies and inhibitors industry global market size, regional shares, competitors with a cytokine-based therapies and inhibitors market share, detailed cytokine-based therapies and inhibitors market segments, market trends and opportunities, and any further data you may need to thrive in the cytokine-based therapies and inhibitors industry. This cytokine-based therapies and inhibitors market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The cytokine-based therapies and inhibitors market size has grown steadily in recent years. It will grow from $146.95 billion in 2025 to $153.47 billion in 2026 at a compound annual growth rate (CAGR) of 4.4%. The growth in the historic period can be attributed to limited availability of cytokine modulators, early-stage research in immunotherapies, reliance on conventional treatment methods, increasing prevalence of cancer and autoimmune diseases, limited biologics manufacturing capabilities.
The cytokine-based therapies and inhibitors market size is expected to see steady growth in the next few years. It will grow to $180.3 billion in 2030 at a compound annual growth rate (CAGR) of 4.1%. The growth in the forecast period can be attributed to advances in recombinant cytokine engineering, rising investment in immuno-oncology and inflammatory disorder treatments, integration of AI for drug discovery, growing biopharmaceutical manufacturing infrastructure, expansion of clinical trials and personalized medicine initiatives. Major trends in the forecast period include rising adoption of cytokine-based therapies in oncology, expansion of targeted immune modulation therapies, growth in biopharmaceutical research and clinical trials, increasing focus on personalized medicine and precision therapies, enhanced regulatory and safety compliance in drug development.
The increasing incidence of autoimmune disorders is anticipated to drive the growth of the cytokine-based therapies and inhibitors market in the coming years. Autoimmune disorders are conditions in which the immune system mistakenly attacks the body's own healthy cells and tissues, misidentifying them as foreign threats. The rise in autoimmune disorders is largely linked to dietary changes, particularly the growing intake of highly processed foods, which can disrupt gut microbiota and impair immune regulation. Cytokine-based therapies and inhibitors help regulate immune activity by targeting specific cytokines involved in inflammatory processes, making them effective treatment options for managing autoimmune conditions. For instance, in February 2024, according to Arthritis Australia, an Australia-based non-profit organization, an estimated 562,378 Australians are projected to be living with rheumatoid arthritis (RA) in 2025, accounting for 14% of all arthritis cases that year. By 2040, this figure is expected to increase by 33% to 748,721 individuals, representing an additional 186,343 Australians living with RA compared with 2025. Therefore, the rising incidence of autoimmune disorders is contributing to the growth of the cytokine-based therapies and inhibitors market.
Major companies operating in the cytokine-based therapy and inhibitor market are emphasizing the development of innovative treatment approaches, such as intravesical cytokine maintenance immunotherapy, to enhance the durability of complete responses and lower recurrence rates in patients with Bacillus Calmette-Guerin (BCG)-unresponsive non-muscle invasive bladder cancer (NMIBC). Intravesical cytokine maintenance immunotherapy involves administering immune-stimulating cytokines directly into the bladder, followed by sustained maintenance dosing to continuously activate localized immune responses and suppress tumor regrowth. For instance, in April 2024, the US Food and Drug Administration approved nogapendekin alfa inbakicept-pmln (Anktiva), a novel cytokine-based therapy indicated for use in combination with Bacillus Calmette-Guerin. This advanced immunotherapy functions as a fusion protein that targets interleukin-15 (IL-15) signaling pathways, activating CD122-positive immune cells such as natural killer (NK) cells and CD8-positive T cells. This mechanism reflects the core principles of cytokine-based therapy, which harnesses immune signaling proteins like IL-15 to strengthen immune surveillance and anti-tumor activity.
In May 2024, Vertex Pharmaceuticals Incorporated, a US-based biotechnology company, acquired Alpine Immune Sciences, Inc. for approximately $4.9 billion in cash. Through this acquisition, Vertex aims to enhance its immunology portfolio by integrating Alpine's protein engineering platform and its lead therapeutic candidate, povetacicept, to address serious autoimmune and kidney diseases. Alpine Immune Sciences, Inc. is a US-based clinical-stage biotechnology company focused on developing innovative protein-based immunotherapies.
Major companies operating in the cytokine-based therapies and inhibitors market are Pfizer Inc., Johnson & Johnson, F. Hoffmann-La Roche Ltd, AbbVie Inc., Novartis AG, Sanofi SA, Bristol-Myers Squibb Company, AstraZeneca Plc, GlaxoSmithKline plc, Eli Lilly and Company, Amgen Inc, UCB S.A., Biocon Limited.
North America was the largest region in the cytokine-based therapies and inhibitors market in 2025. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the cytokine-based therapies and inhibitors market report are Asia-Pacific, South East Asia, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
The countries covered in the cytokine-based therapies and inhibitors market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Taiwan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The cytokine-based therapies and inhibitors market consists of revenues earned by entities providing services such as the development, manufacturing, and commercialization of cytokine-targeted drugs. The market value includes the value of related goods sold by the service provider or included within the service offering. The cytokine-based therapies and inhibitors market includes sales of products such as colony-stimulating factors, transforming growth factors, and monoclonal antibodies. Values in this market are 'factory gate' values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Cytokine-Based Therapies And Inhibitors Market Global Report 2026 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses cytokine-based therapies and inhibitors market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for cytokine-based therapies and inhibitors ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward, including technological disruption, regulatory shifts, and changing consumer preferences? The cytokine-based therapies and inhibitors market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, total addressable market (TAM), market attractiveness score (MAS), competitive landscape, market shares, company scoring matrix, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
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