Oligonucleotide Synthesis Market - Global Industry Size, Share, Trends, Opportunity, and Forecast, Segmented By Product Type, By Application, By End User, By Region and Competition, 2020-2030F

Description

The Global Oligonucleotide Synthesis Market was valued at USD 4.26 billion in 2024 and is projected to reach USD 8.97 billion by 2030, growing at a CAGR of 13.21% during the forecast period. This market plays a vital role in advancing biopharmaceutical innovation, serving as a cornerstone for applications such as gene editing, molecular diagnostics, and RNA-based therapies. The sector's rapid expansion is closely tied to breakthroughs in genomics and personalized medicine, where demand for high-fidelity, tailor-made oligonucleotides has soared. As pharmaceutical companies and research institutions increasingly focus on RNA therapeutics and gene-targeting treatments, the need for scalable and precise oligonucleotide production continues to intensify. Clinical trials-particularly in North America and Europe-underscore the broadening scope of oligonucleotide-based treatments. With robust investments, growing biotech collaborations, and the evolution of synthesis technologies, the market is positioned for sustained innovation and global adoption.

Market Overview
Forecast Period	2026-2030
Market Size 2024	USD 4.26 Billion
Market Size 2030	USD 8.97 Billion
CAGR 2025-2030	13.21%
Fastest Growing Segment	Therapeutics
Largest Market	North America

Key Market Drivers

RNA-Based Therapeutics

RNA-based therapeutics have emerged as a powerful tool for treating a wide range of diseases, propelling the demand for synthetic oligonucleotides. Applications like small interfering RNA (siRNA), antisense oligonucleotides (ASOs), and messenger RNA (mRNA) therapies rely on precise nucleotide synthesis. The global spotlight on mRNA vaccines-particularly those developed for COVID-19-has significantly increased awareness and investment in this segment. Beyond vaccines, RNA-based therapeutics are targeting chronic conditions and rare genetic disorders by altering or silencing specific gene expressions. These therapies require advanced oligonucleotide sequences manufactured with stringent quality and precision standards, highlighting the growing dependence on oligonucleotide synthesis for modern drug development pipelines.

Key Market Challenges

Efficiency and Scalability

Despite strong demand, the industry faces persistent challenges in scaling up oligonucleotide production without compromising quality. High-throughput synthesis processes require consistent optimization to maintain cost-effectiveness, especially as research moves from lab-scale to commercial-scale applications. Additionally, synthesizing complex, longer, or chemically modified oligonucleotides can be resource-intensive, requiring specialized equipment and infrastructure. Compliance with global regulatory standards adds another layer of complexity, necessitating rigorous quality controls. These hurdles can increase production timelines and costs, potentially slowing down commercialization, especially for startups and smaller biopharma companies.

Key Market Trends

Therapeutic Advancements

Therapeutic innovation remains a defining trend in the oligonucleotide synthesis market. The success of mRNA vaccines has validated RNA-based platforms, sparking a surge in R&D investments aimed at tackling conditions like cancer, neurodegenerative diseases, and rare genetic disorders. Oligonucleotides are central to these developments, forming the basis for antisense therapies, RNA interference (RNAi), and gene-editing technologies such as CRISPR. This growing reliance on synthetic nucleic acids has intensified efforts to develop faster, purer, and more cost-efficient synthesis technologies. As pharmaceutical pipelines increasingly include nucleic acid-based drugs, demand for specialized synthesis services and materials is expected to rise significantly, solidifying the sector's strategic importance in modern medicine.

Key Market Players

Thermo Fisher Scientific Inc
Agilent Technologies, Inc.
Merck KGaA
BIO-Synthesis Inc
Eurofins Scientific SE
Danaher Corporation
Ajinomoto Bio-Pharma Services
Biogen Inc.
Ionis Pharmaceuticals, Inc.
Sarepta Therapeutics, Inc.

Report Scope

In this report, the Oligonucleotide Synthesis Market has been segmented into the following categories, in addition to the industry trends which have also been detailed below:

Oligonucleotide Synthesis Market, By Product Type:

Synthesized Oligonucleotide Products
Reagents
Equipment
Services

Oligonucleotide Synthesis Market, By Application:

Research
Therapeutics
Diagnostics

Oligonucleotide Synthesis Market, By End User:

Academic Research Institutes
Pharmaceutical & Biotechnology Companies
Hospital & Diagnostic Laboratories

Oligonucleotide Synthesis Market, By Region:

North America
United States
Mexico
Canada
Europe
France
Germany
United Kingdom
Italy
Spain
Asia-Pacific
China
India
South Korea
Japan
Australia
South America
Brazil
Argentina
Colombia
Middle East and Africa
South Africa
Saudi Arabia
UAE

Competitive Landscape

Company Profiles: Detailed analysis of the major companies present in the Oligonucleotide Synthesis Market.

Available Customizations

Oligonucleotide Synthesis Market report with the given market data, TechSci Research offers customizations according to a company's specific needs. The following customization options are available for the report:

1. Product Overview

1.1. Market Definition
1.2. Scope of the Market
- 1.2.1. Markets Covered
- 1.2.2. Years Considered for Study
- 1.2.3. Key Market Segmentations

2. Research Methodology

2.1. Objective of the Study
2.2. Baseline Methodology
2.3. Key Industry Partners
2.4. Major Association and Secondary Sources
2.5. Forecasting Methodology
2.6. Data Triangulation & Validations
2.7. Assumptions and Limitations

3. Executive Summary

3.1. Overview of the Market
3.2. Overview of Key Market Segmentations
3.3. Overview of Key Market Players
3.4. Overview of Key Regions/Countries
3.5. Overview of Market Drivers, Challenges, Trends

4. Voice of Customer

5. Global Oligonucleotide Synthesis Market Outlook

5.1. Market Size & Forecast
- 5.1.1. By Value
5.2. Market Share & Forecast
- 5.2.1. By Product Type (Synthesized Oligonucleotide Products, Reagents, Equipment, and Services)
- 5.2.2. By Application (Research, Therapeutics, and Diagnostics)
- 5.2.3. By End User (Academic Research Institutes, Pharmaceutical and Biotechnology Companies, and Hospital and Diagnostic Laboratories)
- 5.2.4. By Region
- 5.2.5. By Company (2024)
5.3. Market Map

6. North America Oligonucleotide Synthesis Market Outlook

6.1. Market Size & Forecast
- 6.1.1. By Value
6.2. Market Share & Forecast
- 6.2.1. By Product Type
- 6.2.2. By Application
- 6.2.3. By End User
- 6.2.4. By Country
6.3. North America: Country Analysis
- 6.3.1. United States Oligonucleotide Synthesis Market Outlook
  - 6.3.1.1. Market Size & Forecast
    - 6.3.1.1.1. By Value
  - 6.3.1.2. Market Share & Forecast
    - 6.3.1.2.1. By Product Type
    - 6.3.1.2.2. By Application
    - 6.3.1.2.3. By End User
- 6.3.2. Canada Oligonucleotide Synthesis Market Outlook
  - 6.3.2.1. Market Size & Forecast
    - 6.3.2.1.1. By Value
  - 6.3.2.2. Market Share & Forecast
    - 6.3.2.2.1. By Product Type
    - 6.3.2.2.2. By Application
    - 6.3.2.2.3. By End User
- 6.3.3. Mexico Oligonucleotide Synthesis Market Outlook
  - 6.3.3.1. Market Size & Forecast
    - 6.3.3.1.1. By Value
  - 6.3.3.2. Market Share & Forecast
    - 6.3.3.2.1. By Product Type
    - 6.3.3.2.2. By Application
    - 6.3.3.2.3. By End User

7. Europe Oligonucleotide Synthesis Market Outlook

7.1. Market Size & Forecast
- 7.1.1. By Value
7.2. Market Share & Forecast
- 7.2.1. By Product Type
- 7.2.2. By Application
- 7.2.3. By End User
- 7.2.4. By Country
7.3. Europe: Country Analysis
- 7.3.1. Germany Oligonucleotide Synthesis Market Outlook
  - 7.3.1.1. Market Size & Forecast
    - 7.3.1.1.1. By Value
  - 7.3.1.2. Market Share & Forecast
    - 7.3.1.2.1. By Product Type
    - 7.3.1.2.2. By Application
    - 7.3.1.2.3. By End User
- 7.3.2. United Kingdom Oligonucleotide Synthesis Market Outlook
  - 7.3.2.1. Market Size & Forecast
    - 7.3.2.1.1. By Value
  - 7.3.2.2. Market Share & Forecast
    - 7.3.2.2.1. By Product Type
    - 7.3.2.2.2. By Application
    - 7.3.2.2.3. By End User
- 7.3.3. Italy Oligonucleotide Synthesis Market Outlook
  - 7.3.3.1. Market Size & Forecast
    - 7.3.3.1.1. By Value
  - 7.3.3.2. Market Share & Forecast
    - 7.3.3.2.1. By Product Type
    - 7.3.3.2.2. By Application
    - 7.3.3.2.3. By End User
- 7.3.4. France Oligonucleotide Synthesis Market Outlook
  - 7.3.4.1. Market Size & Forecast
    - 7.3.4.1.1. By Value
  - 7.3.4.2. Market Share & Forecast
    - 7.3.4.2.1. By Product Type
    - 7.3.4.2.2. By Application
    - 7.3.4.2.3. By End User
- 7.3.5. Spain Oligonucleotide Synthesis Market Outlook
  - 7.3.5.1. Market Size & Forecast
    - 7.3.5.1.1. By Value
  - 7.3.5.2. Market Share & Forecast
    - 7.3.5.2.1. By Product Type
    - 7.3.5.2.2. By Application
    - 7.3.5.2.3. By End User

8. Asia-Pacific Oligonucleotide Synthesis Market Outlook

8.1. Market Size & Forecast
- 8.1.1. By Value
8.2. Market Share & Forecast
- 8.2.1. By Product Type
- 8.2.2. By Application
- 8.2.3. By End User
- 8.2.4. By Country
8.3. Asia-Pacific: Country Analysis
- 8.3.1. China Oligonucleotide Synthesis Market Outlook
  - 8.3.1.1. Market Size & Forecast
    - 8.3.1.1.1. By Value
  - 8.3.1.2. Market Share & Forecast
    - 8.3.1.2.1. By Product Type
    - 8.3.1.2.2. By Application
    - 8.3.1.2.3. By End User
- 8.3.2. India Oligonucleotide Synthesis Market Outlook
  - 8.3.2.1. Market Size & Forecast
    - 8.3.2.1.1. By Value
  - 8.3.2.2. Market Share & Forecast
    - 8.3.2.2.1. By Product Type
    - 8.3.2.2.2. By Application
    - 8.3.2.2.3. By End User
- 8.3.3. Japan Oligonucleotide Synthesis Market Outlook
  - 8.3.3.1. Market Size & Forecast
    - 8.3.3.1.1. By Value
  - 8.3.3.2. Market Share & Forecast
    - 8.3.3.2.1. By Product Type
    - 8.3.3.2.2. By Application
    - 8.3.3.2.3. By End User
- 8.3.4. South Korea Oligonucleotide Synthesis Market Outlook
  - 8.3.4.1. Market Size & Forecast
    - 8.3.4.1.1. By Value
  - 8.3.4.2. Market Share & Forecast
    - 8.3.4.2.1. By Product Type
    - 8.3.4.2.2. By Application
    - 8.3.4.2.3. By End User
- 8.3.5. Australia Oligonucleotide Synthesis Market Outlook
  - 8.3.5.1. Market Size & Forecast
    - 8.3.5.1.1. By Value
  - 8.3.5.2. Market Share & Forecast
    - 8.3.5.2.1. By Product Type
    - 8.3.5.2.2. By Application
    - 8.3.5.2.3. By End User

9. South America Oligonucleotide Synthesis Market Outlook

9.1. Market Size & Forecast
- 9.1.1. By Value
9.2. Market Share & Forecast
- 9.2.1. By Product Type
- 9.2.2. By Application
- 9.2.3. By End User
- 9.2.4. By Country
9.3. South America: Country Analysis
- 9.3.1. Brazil Oligonucleotide Synthesis Market Outlook
  - 9.3.1.1. Market Size & Forecast
    - 9.3.1.1.1. By Value
  - 9.3.1.2. Market Share & Forecast
    - 9.3.1.2.1. By Product Type
    - 9.3.1.2.2. By Application
    - 9.3.1.2.3. By End User
- 9.3.2. Argentina Oligonucleotide Synthesis Market Outlook
  - 9.3.2.1. Market Size & Forecast
    - 9.3.2.1.1. By Value
  - 9.3.2.2. Market Share & Forecast
    - 9.3.2.2.1. By Product Type
    - 9.3.2.2.2. By Application
    - 9.3.2.2.3. By End User
- 9.3.3. Colombia Oligonucleotide Synthesis Market Outlook
  - 9.3.3.1. Market Size & Forecast
    - 9.3.3.1.1. By Value
  - 9.3.3.2. Market Share & Forecast
    - 9.3.3.2.1. By Product Type
    - 9.3.3.2.2. By Application
    - 9.3.3.2.3. By End User

10. Middle East and Africa Oligonucleotide Synthesis Market Outlook

10.1. Market Size & Forecast
- 10.1.1. By Value
10.2. Market Share & Forecast
- 10.2.1. By Product Type
- 10.2.2. By Application
- 10.2.3. By End User
- 10.2.4. By Country
10.3. MEA: Country Analysis
- 10.3.1. South Africa Oligonucleotide Synthesis Market Outlook
  - 10.3.1.1. Market Size & Forecast
    - 10.3.1.1.1. By Value
  - 10.3.1.2. Market Share & Forecast
    - 10.3.1.2.1. By Product Type
    - 10.3.1.2.2. By Application
    - 10.3.1.2.3. By End User
- 10.3.2. Saudi Arabia Oligonucleotide Synthesis Market Outlook
  - 10.3.2.1. Market Size & Forecast
    - 10.3.2.1.1. By Value
  - 10.3.2.2. Market Share & Forecast
    - 10.3.2.2.1. By Product Type
    - 10.3.2.2.2. By Application
    - 10.3.2.2.3. By End User
- 10.3.3. UAE Oligonucleotide Synthesis Market Outlook
  - 10.3.3.1. Market Size & Forecast
    - 10.3.3.1.1. By Value
  - 10.3.3.2. Market Share & Forecast
    - 10.3.3.2.1. By Product Type
    - 10.3.3.2.2. By Application
    - 10.3.3.2.3. By End User

11. Market Dynamics

11.1. Drivers
11.2. Challenges

12. Market Trends & Developments

12.1. Recent Development
12.2. Mergers & Acquisitions

13. Global Oligonucleotide Synthesis Market: SWOT Analysis

14. Porter's Five Forces Analysis

14.1. Competition in the Industry
14.2. Potential of New Entrants
14.3. Power of Suppliers
14.4. Power of Customers
14.5. Threat of Substitute Treatment Types

15. Competitive Landscape

15.1. Thermo Fisher Scientific Inc
- 15.1.1. Business Overview
- 15.1.2. Company Snapshot
- 15.1.3. Products & Services
- 15.1.4. Financials (As Reported)
- 15.1.5. Recent Developments
- 15.1.6. Key Personnel Details
- 15.1.7. SWOT Analysis
15.2. Agilent Technologies, Inc.
15.3. Merck KGaA
15.4. BIO-Synthesis Inc
15.5. Eurofins Scientific SE
15.6. Danaher Corporation
15.7. Ajinomoto Bio-Pharma Services
15.8. Biogen Inc.
15.9. Ionis Pharmaceuticals, Inc.
15.10. Sarepta Therapeutics, Inc.