PUBLISHER: DelveInsight | PRODUCT CODE: 1096497
PUBLISHER: DelveInsight | PRODUCT CODE: 1096497
DelveInsight's, "Dyskinesia- Pipeline Insight, 2022," report provides comprehensive insights about 40+ companies and 45+ pipeline drugs in Dyskinesia pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Dyskinesia's are involuntary, erratic, writhing movements of the face, arms, legs or trunk. They are often fluid and dance-like, but they may also cause rapid jerking or slow and extended muscle spasms. They are not a symptom of Parkinson's itself. Rather, they are a complication from some Parkinson's medications. They may be caused by systemic, metabolic, endocrinologic, structural, vascular, infectious or inherited degenerative conditions, or be toxin- or drug-induced. Dyskinesia's usually begin after a few years of treatment with levodopa and can often be alleviated by adjusting dopaminergic medications. Younger people with PD are thought to develop earlier motor fluctuations and dyskinesia's in response to levodopa. Dyskinesia's may be mild and non-bothersome, or they can be severe. Most people with Parkinson's prefer to be "on" with some dyskinesia's rather than "off" and unable to move well. However, for some people, dyskinesia's can be severe enough that they interfere with normal functioning. The most common kind of dyskinesias are "peak dose." These occur when the concentration of levodopa in the blood is at its highest - usually one to two hours after the persons takes it. This typically matches up with when the medications are working best to control motor symptoms. In the earliest stages of Parkinson's, they are usually not bothersome, and person may not even notice the extra movements. With many non-drug-induced dyskinesias, treatment of the underlying condition may be sufficient to eliminate the movements, although temporary treatment may be required to control the movements if they are severe. Drug-induced dyskinesias often resolve when the offending drug is discontinued. A notable exception is tardive dyskinesia, which is caused by exposure to dopamine receptor blocking drugs, the majority of which are antipsychotic agents. Tardive dyskinesias will persist, or may even develop after the causative agent has been stopped and may not spontaneously remit. Another commonly encountered form of drug-induced dyskinesia is seen in patients with Parkinson's disease who are receiving levodopa. Medications which deplete dopamine are most successful in treating choreiform dyskinesias, although anticholinergics, GABAergics, serotonergics, and calcium channel blocking agents have been reportedly beneficial in some cases. Treatment of levodopa-induced dyskinesias requires manipulation of the patient's antiparkinsonian drug regimen.
"Dyskinesia- Pipeline Insight, 2022" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Dyskinesia pipeline landscape is provided which includes the disease overview and Dyskinesia treatment guidelines. The assessment part of the report embraces, in depth Dyskinesia commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Dyskinesia collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
The companies and academics are working to assess challenges and seek opportunities that could influence Dyskinesia R&D. The therapies under development are focused on novel approaches to treat/improve Dyskinesia.
This segment of the Dyskinesia report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
JM-010 is developed as an innovative approach to accelerate the development of new treatment options for Parkinson's disease patients suffering from dyskinesia.JM-010 acts as a dual molecular switch by which the target efficacies of two existing and safe medications are perfectly fine-tuned to effectively treat the disease. Using a proprietary formulation, JM-010 targets central mechanisms underlying the development of dyskinesia in Parkinson's disease. JM-010 has successfully demonstrated its efficacy and safety in preclinical studies, as well as in Phase I clinical safety and Phase II clinical proof of concept studies. Currently, JM-010 is undergoing Phase II clinical studies in Europe and US.
NLX-112 (also known as befiradol or F13640) is a novel compound that activates serotonin 5-HT1A receptors. NLX-112 has two main advantages over older compounds: NLX-112 is extremely selective for the 5-HT1A receptor, with over 1000-fold selectivity compared to other types of receptor types, and NLX-112 is a full agonist at 5-HT1A receptors, maximally activating the receptor. Currently, the drug is in Phase II stage of clinical trial evaluation for the treatment of L-DOPA-induced dyskinesia in Parkinson's disease.
CPL500-036 is a novel PDE10A inhibitor developed in laboratories of Celon Pharma S.A. It is characterized by high in vitro and in vivo potency, it is highly selective and has good oral bioavailability (F > 70%) and BBB penetration (B/P = 0,4) in rats. Several behavioural studies have confirmed its antipsychotic and precognitive action in rats (MED > 0,03 mg/kg). CPL500-036 is currently investigated in clinical trials. In October 2019 CelonPharma S.A. completed a phase I clinical trial for CPL500-036.Currently, the drug is in Phase II stage of clinical trial evaluation for the treatment of Medication-Induced dyskinesia.
This segment of the report provides insights about the different Dyskinesia drugs segregated based on following parameters that define the scope of the report, such as:
There are approx. 40+ key companies which are developing the therapies for Dyskinesia. The companies which have their Dyskinesia drug candidates in the most advanced stage, i.e. phase II include, Contera Pharma.
DelveInsight's report covers around 45+ products under different phases of clinical development like:
Dyskinesia pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as:
Products have been categorized under various Molecule types such as:
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses
Dyskinesia therapeutic drugs key players involved in developing key drugs.
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Dyskinesia drugs.