PUBLISHER: DelveInsight | PRODUCT CODE: 1179475
PUBLISHER: DelveInsight | PRODUCT CODE: 1179475
DelveInsight's 'Parkinson's disease Levodopa-induced dyskinesia (PD-LID) - Epidemiology Forecast - 2032' report delivers an in-depth understanding of the historical and forecasted epidemiology of Parkinson's disease Levodopa-induced dyskinesia in the United States, Japan, EU4 (Germany, Spain, Italy, France) and the UK.
Parkinson's disease Levodopa-induced dyskinesia (PD-LID): Disease Understanding
Parkinson's disease Levodopa-induced dyskinesia (PD-LID) Overview
According to the Parkinson's Foundation, Parkinson's disease (PD) is a neurodegenerative disorder that affects dopamine-producing (dopaminergic) neurons predominately in a specific area of the brain called the substantia nigra.
Treatment involves pharmacologic approaches (typically with levodopa preparations prescribed with or without other medications) and nonpharmacologic approaches (such as exercise, occupational, and speech therapies). Approaches such as deep brain stimulation (DBS) and treatment with levodopa-carbidopa enteral suspension can help individuals with medication-resistant tremors, worsening symptoms when the medication wears off, and dyskinesias.
Levodopa (L-DOPA) is the most effective drug for treating PD, but motor fluctuations and dyskinesia complicate its long-term use. Dyskinesia may be mild at the beginning but may progress to become a disabling symptom and may interfere with the quality of life. There are three types of dyskinesias identified to date, off-period dystonia, peak dose dyskinesia, and diphasic dyskinesia. Off-time dyskinesia is usually encountered during the night or early morning. Thus, the administration of L-DOPA formulations having a longer half-life at night can effectively treat off-time dyskinesia. However, diphasic dyskinesia is treated by increasing the dose of dopaminergic drugs administered; contrarily, peak dose dyskinesia is generally performed by reducing the dose of the dopaminergic drug administered.
The treatment strategy includes identifying the kind of dyskinesia and tailoring treatment accordingly. Peak-dose dyskinesia is treated mainly by reducing individual doses of levodopa and adding amantadine and dopamine agonists, whereas off-period dystonia often responds to baclofen and botulinum toxin injections. Diphasic dyskinesias are the most difficult to treat, particularly in patients with young-onset PD. While fractionation of levodopa dosage is the most frequently utilized strategy, many patients require DBS to control their troublesome motor fluctuations and LIDs. Various emerging drugs currently in development promise to provide better control of LIDs and other levodopa-related complications shortly.
The Parkinson's disease levodopa-induced dyskinesia epidemiology division provides insights into the historical and current patient pool and the forecast trend for every seven major countries. It helps recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the report also provides the diagnosed patient pool and their trends, along with assumptions undertaken.
Key Findings
The disease epidemiology covered in the report provides historical and forecasted Parkinson's disease levodopa-induced dyskinesia epidemiology segmented as the number of patients developing PD-LID and type-specific cases of PD-LID. The report includes the prevalent Parkinson's disease levodopa-induced dyskinesia in the 7MM covering the United States, Japan, EU4 countries (Germany, France, Italy, and Spain) and the United Kingdom from 2019 to 2032.
The epidemiology segment also provides the Parkinson's disease levodopa-induced dyskinesia (PD-LID) epidemiology data and findings across the United States, Japan, EU4 countries (Germany, France, Italy, and Spain) and the United Kingdom.
The total number of cases of Parkinson's disease levodopa-induced dyskinesia (PD-LID) in the 7MM countries were over 580,000 cases in 2021.
As per the estimates, Germany had the highest prevalent patient population of Parkinson's disease levodopa-induced dyskinesia in 2021. Among the EU4 + the UK, Germany had the highest number of cases of Parkinson's disease levodopa-induced dyskinesia (PD-LID), with nearly 67,000 cases, followed by France in 2021. On the other hand, Spain had the lowest number of cases of Parkinson's disease levodopa-induced dyskinesia (PD-LID), with approximately 40,000 cases in 2021.
KOL Views
We interview KOLs and obtain SMEs' opinions through primary research to fill the data gaps and validate our secondary research. The opinion helps understand the total patient population and current treatment pattern. This will support the clients in potential novel treatments by identifying the overall scenario of the indications.
Key Questions Answered
Parkinson's disease levodopa-induced dyskinesia epidemiology report will allow the user to:
Geographies Covered
Study Period: 2019-2032