Nucleic Acid Isolation & Purification Market by Product, Method, Type, Application, End User

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[181 Pages Report] The Nucleic Acid Isolation & Purification Market size was estimated at USD 6.94 billion in 2023 and expected to reach USD 7.58 billion in 2024, at a CAGR 9.59% to reach USD 13.18 billion by 2030.

Nucleic acid isolation and purification is a basic technique in molecular biology, genetics, and biotechnology to extract high-quality nucleic acids, including DNA and RNA, from cells, tissues, or organisms. This process involves steps that separate these essential biomolecules from proteins, lipids, carbohydrates, and potential inhibitors of downstream applications. Several separation techniques, such as column chromatography with silica-based matrices or anion-exchange resins, organic solvent extraction, precipitation using salts or alcohol, and magnetic bead-based separation, can be employed for the selective binding and elution of nucleic acids based on their size, charge, or sequence specificity. Nucleic acid isolation & purification is a cornerstone technique for molecular biology and biotechnology research, enabling scientists to study genetic information at a molecular level, elucidate cellular mechanisms, and develop innovative solutions across various fields, including medicine, agriculture, and environmental science. The market is experiencing significant growth, driven primarily by the rising demand for pure nucleic acids in pharmaceutical and biotechnological industries, favorable government guidelines and regulations, and rising funding for genetic engineering, life science research, and forensics. However, the high cost of setting up nucleic acid isolation and purification facilities and the lack of subject expertise may hinder the market development. Nevertheless, surging innovations in nucleic acid extraction and purification techniques and potential advancements in extracting DNA from plant and animal cells unlock further potential in this dynamic market space.

KEY MARKET STATISTICS
Base Year [2023]	USD 6.94 billion
Estimated Year [2024]	USD 7.58 billion
Forecast Year [2030]	USD 13.18 billion
CAGR (%)	9.59%

Product: Growing demand for automation instruments to reduce the time for routine tasks

Nucleic acid isolation and purification instruments are crucial for efficient and reliable extraction and purification of nucleic acids from various types of samples. Such instruments range from centrifuges, thermocyclers, microplate readers, and spectroscopy systems, which aid in reducing sample contamination ensuring high yields and precision. Kits provide an 'all in one' solution for nucleic acid isolation and purification, typically including all necessary components such as buffers, reagents, and separation tools. These are carefully designed to achieve efficient cell lysis, binding of nucleic acids to a purification matrix, washing, and elution. They can vary in the type of sample they're able to process, the time required for isolation, and the level of equipment needed. Reagents used in nucleic acid isolation and purification typically serve specific functions, the lysis of cells and tissues, the removal of proteins and contaminants, and the precipitation or elution of the nucleic acids. These include organic solvents, salts, detergents, and enzymes. The quality of reagents used directly impacts the yield and integrity of the isolated and purified nucleic acids. The choice between an automated instrument or a manual kit might depend on the scale of operations, labor costs, and the time-sensitivity of tasks. Similarly, the choice of reagents could be influenced by the source material's nature and the nucleic acids' desired purity.

Method: Significant adoption of column-based isolation & purification owing to scalability, allowing effective purification and isolation irrespective of the sample size

Column-based isolation & purification relies on the principle of size exclusion chromatography by using silica-based columns. Nucleic acids bind selectively to the silica matrix in the presence of chaotropic salts while contaminants pass through the column. Subsequent washing and elution steps release pure nucleic acids from the column. This method offers high yield, purity, and consistent results across various sample types. Magnetic bead-based isolation & purification utilizes functionalized magnetic beads that bind to nucleic acids under certain conditions. The sample is mixed with these beads, allowing nucleic acids to attach to their surface. A magnet is then applied to separate the bead-bound nucleic acids from contaminants within the solution. This method provides excellent scalability and flexibility for various sample sizes and throughput requirements and reduces cross-contamination risks due to its closed-tube format. Reagent-based isolation & purification involves reagents such as phenol-chloroform or guanidinium thiocyanate-phenol-chloroform mixtures that separate nucleic acids from proteins via solubility differences under phase separation conditions. After centrifugation, nucleic acids can be recovered from the aqueous phase through precipitation using ethanol or isopropanol. The choice largely depends on the particular requirements of your project. Column-Based isolation & purification offers scalability and high purity, magnetic bead-based isolation favors reproducibility and high-throughput applications, and reagent-based isolation is more economical and suitable for large-scale isolation despite its possible limitations in purity.

Type:

Circulating nucleic acid isolation and purification primarily involves isolating circulating cell-free DNA (cfDNA) and RNA from blood plasma or serum. Genomic DNA Isolation and purification focuses on extracting DNA from the genome, yielding a comprehensive map of genetic information. The purified genomic DNA is applied in various areas, including genealogy, pharmacogenomics, and disease research. Messenger RNA isolation and purification targets messenger RNA (mRNA), and this technique plays a vital role in studying gene regulation. It provides critical insights into gene expression profiles, aiding therapeutic research for cancer and neurological disorders. Micro RNA isolation and purification focuses on micro RNA (miRNA), small non-coding RNA molecules that regulate gene expression. Exploring miRNA has profound implications for understanding diseases at the molecular level, especially oncology, cardiology, and virology. PCR Cleanup is a technique to purify PCR amplification products. Removing primers, nucleotides, enzymes, and salts is vital, which may interfere with subsequent enzymatic reactions. Plasmid DNA isolation and purification targeting plasmid DNA isolation is essential for genetic engineering and gene cloning. As genetic carriers, plasmids have significant biotechnological applications, including gene therapy and vaccine development. The total RNA Isolation and purification method aims to obtain all types of RNA, including mRNA, tRNA, and rRNA. It's pivotal in various fields of study, notably in exploring the transcriptome for understanding gene function, structure, and expression. Illustratively, the isolation and purification method choice pivots on the specific nucleic acid type and research necessity. Advancements in these techniques are continually broadening the scope, invigorating unprecedented opportunities in the genomic and genetic research sphere.

Application: Wider application of nucleic acid isolation & purification in diagnostics to provide guidance on therapy

In agriculture and animal research, nucleic acid helps to detect genetically modified organisms (GMOs), identify pathogens in crops and livestock, and facilitate selective breeding for desirable traits. Advancements in nucleic acid extraction techniques have allowed researchers to detect diseases early and develop effective treatment strategies for infected plants or animals. In diagnostics, rapid isolation & purification of nucleic acids are essential for identifying infectious agents such as bacteria or viruses, assisting healthcare professionals to diagnose diseases and take timely medical interventions accurately. Drug discovery and development rely heavily on nucleic acid analysis to identify target molecules associated with specific diseases. Researchers can assess drug efficacy and predict potential side effects by examining the behavior of genes in response to new therapeutic compounds. Personalized medicine uses nucleic acid information for tailoring individualized treatments based on a patient's genetic makeup. This approach allows healthcare providers to optimize therapeutic regimens by considering factors such as drug metabolism or predisposition toward certain diseases. As a result, personalized medicine promises improved treatment outcomes while reducing potential adverse reactions.

End User: Growing usage of nucleic acid isolation & purification by the CROs for reliable results, and fast turnaround time

Academic and government research institutions predominantly use nucleic acid isolation and purification techniques for genetics and molecular biology research. Here, stringent quality standards and the ability to handle a broad range of sample types, including more challenging ones, are critical. Contract research organizations (CROs) regularly deal with drug discovery, preclinical studies, and clinical trials, where precise and high-throughput nucleic acid isolation is vital. They seek solutions with reliable results, scalability, and fast turnaround time. In clinical diagnostics, the accuracy and stability of purification protocols are essential. With the growing importance of genetic testing and personalized medicine in patient care, hospitals, and diagnostic centers need more rapid, sensitive, and scalable kits. Pharmaceutical and biotechnology companies often work on developing novel therapeutics and diagnostic assays. They require highly reliable and scalable techniques for nucleic acid isolation - especially in the production of diagnostics, vaccines, and biopharmaceuticals. Although all end users value reliability, scalability, and quick turnaround time, each has unique requirements influenced by its specific work sector. Consideration of these needs is essential for manufacturers to improve nucleic acid isolation and purification techniques.

Regional Insights

In the Americas, the market is fueled by strong research and development investments in the biotechnology and pharmaceutical sectors and rising incidences of genetic disorders. The increasing molecular biology techniques, the rising prevalence of chronic diseases, and the accelerating need for personalized medicine have enhanced the need for nucleic acid extraction methods in the region. Furthermore, the presence of key organizations, such as Thermo Fisher Scientific Inc., QIAGEN N.V., and Illumina Inc., has been pushing product innovation to cater to the growing demand from research labs and diagnostic centers. The EMEA region is witnessing substantial progress due to increased healthcare expenditure by governments and private entities within Europe's aging population. Additionally, countries within the Middle East and Africa invest heavily in medical infrastructure development projects, further enhancing regional market prospects. The collaboration between numerous universities and research institutes has also accelerated scientific progress in nucleic acid isolation methods. APAC region holds immense potential for expansion of the nucleic acid isolation & purification market due to its rapidly developing healthcare sector, increasing government support for life science research, and high population base. Moreover, Emerging economies, such as China, India, Japan, South Korea, and Australia, present lucrative opportunities for industry stakeholders to tap into unexplored areas of growth potential. In conclusion, the nucleic acid isolation & purification market demonstrates a positive trend across the Americas, EMEA, and APAC regions owing to technological advancements and growing disease prevalence rates necessitating efficient diagnosis and therapeutic interventions.

FPNV Positioning Matrix

The FPNV Positioning Matrix is pivotal in evaluating the Nucleic Acid Isolation & Purification Market. It offers a comprehensive assessment of vendors, examining key metrics related to Business Strategy and Product Satisfaction. This in-depth analysis empowers users to make well-informed decisions aligned with their requirements. Based on the evaluation, the vendors are then categorized into four distinct quadrants representing varying levels of success: Forefront (F), Pathfinder (P), Niche (N), or Vital (V).

Market Share Analysis

The Market Share Analysis is a comprehensive tool that provides an insightful and in-depth examination of the current state of vendors in the Nucleic Acid Isolation & Purification Market. By meticulously comparing and analyzing vendor contributions in terms of overall revenue, customer base, and other key metrics, we can offer companies a greater understanding of their performance and the challenges they face when competing for market share. Additionally, this analysis provides valuable insights into the competitive nature of the sector, including factors such as accumulation, fragmentation dominance, and amalgamation traits observed over the base year period studied. With this expanded level of detail, vendors can make more informed decisions and devise effective strategies to gain a competitive edge in the market.

Key Company Profiles

The report delves into recent significant developments in the Nucleic Acid Isolation & Purification Market, highlighting leading vendors and their innovative profiles. These include A&A Biotechnology, Abcam PLC, ABNova Corporation, Agilent Technologies Inc., Analytik Jena GmbH+Co. KG, Becton, Dickinson and Company, Bio-Rad Laboratories, Inc., Biomatik Corporation, Bioneer Corporation, Danaher Corporation, F. Hoffmann-La Roche Ltd., Genaxxon bioscience GmbH, Geneaid Biotech Ltd., GeneProof a.s, Genscript Biotech, Hamilton Company, HiMedia Laboratories Private Limited, Illumina Inc., MACHEREY-NAGEL GmbH & Co. KG, Merck KGaA, MP Biomedicals, New England Biolabs, Inc., Norgen Biotec Corp., NZYTech, Omega Bio-tek, Inc., Perkin Elmer Inc., Promega Corporation, Takara Bio Inc., Thermo Fisher Scientific Inc., and Zymo Research Corporation.

Market Segmentation & Coverage

This research report categorizes the Nucleic Acid Isolation & Purification Market to forecast the revenues and analyze trends in each of the following sub-markets:

Product
- Instruments
- Kits
- Reagents

Method
- Column-Based Isolation & Purification
- Magnetic Bead-Based Isolation & Purification
- Reagent-Based Isolation & Purification

Type
- Circulating Nucleic Acid Isolation & Purification
- Genomic DNA Isolation & Purification
- Messenger RNA Isolation & Purification
- Micro RNA Isolation & Purification
- PCR Cleanup
- Plasmid DNA Isolation & Purification
- Total RNA Isolation & Purification

Application
- Agriculture & Animal Research
- Diagnostics
- Drug Discovery & Development
- Personalized Medicine

End User
- Academic & Government Research Institutes
- Contract Research Organizations
- Hospitals & Diagnostic Centers
- Pharmaceutical & Biotechnology Companies

Region
- Americas
  - Argentina
  - Brazil
  - Canada
  - Mexico
  - United States
    - California
    - Florida
    - Illinois
    - New York
    - Ohio
    - Pennsylvania
    - Texas
- Asia-Pacific
  - Australia
  - China
  - India
  - Indonesia
  - Japan
  - Malaysia
  - Philippines
  - Singapore
  - South Korea
  - Taiwan
  - Thailand
  - Vietnam

Europe, Middle East & Africa
- Denmark
- Egypt
- Finland
- France
- Germany
- Israel
- Italy
- Netherlands
- Nigeria
- Norway
- Poland
- Qatar
- Russia
- Saudi Arabia
- South Africa
- Spain
- Sweden
- Switzerland
- Turkey
- United Arab Emirates
- United Kingdom

The report offers valuable insights on the following aspects:

1. Market Penetration: It presents comprehensive information on the market provided by key players.

2. Market Development: It delves deep into lucrative emerging markets and analyzes the penetration across mature market segments.

3. Market Diversification: It provides detailed information on new product launches, untapped geographic regions, recent developments, and investments.

4. Competitive Assessment & Intelligence: It conducts an exhaustive assessment of market shares, strategies, products, certifications, regulatory approvals, patent landscape, and manufacturing capabilities of the leading players.

5. Product Development & Innovation: It offers intelligent insights on future technologies, R&D activities, and breakthrough product developments.

The report addresses key questions such as:

1. What is the market size and forecast of the Nucleic Acid Isolation & Purification Market?

2. Which products, segments, applications, and areas should one consider investing in over the forecast period in the Nucleic Acid Isolation & Purification Market?

3. What are the technology trends and regulatory frameworks in the Nucleic Acid Isolation & Purification Market?

4. What is the market share of the leading vendors in the Nucleic Acid Isolation & Purification Market?

5. Which modes and strategic moves are suitable for entering the Nucleic Acid Isolation & Purification Market?

Product Code: MRR-783E443AFB64

1. Preface

1.1. Objectives of the Study
1.2. Market Segmentation & Coverage
1.3. Years Considered for the Study
1.4. Currency & Pricing
1.5. Language
1.6. Stakeholders

2. Research Methodology

2.1. Define: Research Objective
2.2. Determine: Research Design
2.3. Prepare: Research Instrument
2.4. Collect: Data Source
2.5. Analyze: Data Interpretation
2.6. Formulate: Data Verification
2.7. Publish: Research Report
2.8. Repeat: Report Update

3. Executive Summary

4. Market Overview

5. Market Insights

5.1. Market Dynamics
- 5.1.1. Drivers
  - 5.1.1.1. Rising demand of pure nucleic acids in pharmaceutical and biotechnological industries
  - 5.1.1.2. Favorable government guidelines and regulations for DNA extraction process
  - 5.1.1.3. Increasing funding in genetic engineering, life science research, and forensics
- 5.1.2. Restraints
  - 5.1.2.1. High cost of set-up for nucleic acid isolation & purification
- 5.1.3. Opportunities
  - 5.1.3.1. Emerging innovations in nucleic acid extraction and purification techniques
  - 5.1.3.2. Potential developments to extract DNA from plant and animal cells
- 5.1.4. Challenges
  - 5.1.4.1. Lack of subject matter expertise in the field of nucleic acid
5.2. Market Segmentation Analysis
- 5.2.1. Product: Growing demand for automation instruments to reduce the time for routine tasks
- 5.2.2. Method: Significant adoption of column-based isolation & purification owing to scalability, allowing effective purification and isolation irrespective of the sample size

5.2.3. Type:

5.2.4. Application: Wider application of nucleic acid isolation & purification in diagnostics to provide guidance on therapy
5.2.5. End User: Growing usage of nucleic acid isolation & purification by the CROs for reliable results, and fast turnaround time

5.3. Market Disruption Analysis
5.4. Porter's Five Forces Analysis
- 5.4.1. Threat of New Entrants
- 5.4.2. Threat of Substitutes
- 5.4.3. Bargaining Power of Customers
- 5.4.4. Bargaining Power of Suppliers
- 5.4.5. Industry Rivalry
5.5. Value Chain & Critical Path Analysis
5.6. Pricing Analysis
5.7. Technology Analysis
5.8. Patent Analysis
5.9. Trade Analysis
5.10. Regulatory Framework Analysis

6. Nucleic Acid Isolation & Purification Market, by Product

6.1. Introduction
6.2. Instruments
6.3. Kits
6.4. Reagents

7. Nucleic Acid Isolation & Purification Market, by Method

7.1. Introduction
7.2. Column-Based Isolation & Purification
7.3. Magnetic Bead-Based Isolation & Purification
7.4. Reagent-Based Isolation & Purification

8. Nucleic Acid Isolation & Purification Market, by Type

8.1. Introduction
8.2. Circulating Nucleic Acid Isolation & Purification
8.3. Genomic DNA Isolation & Purification
8.4. Messenger RNA Isolation & Purification
8.5. Micro RNA Isolation & Purification
8.6. PCR Cleanup
8.7. Plasmid DNA Isolation & Purification
8.8. Total RNA Isolation & Purification

9. Nucleic Acid Isolation & Purification Market, by Application

9.1. Introduction
9.2. Agriculture & Animal Research
9.3. Diagnostics
9.4. Drug Discovery & Development
9.5. Personalized Medicine

10. Nucleic Acid Isolation & Purification Market, by End User

10.1. Introduction
10.2. Academic & Government Research Institutes
10.3. Contract Research Organizations
10.4. Hospitals & Diagnostic Centers
10.5. Pharmaceutical & Biotechnology Companies

11. Americas Nucleic Acid Isolation & Purification Market

11.1. Introduction
11.2. Argentina
11.3. Brazil
11.4. Canada
11.5. Mexico
11.6. United States

12. Asia-Pacific Nucleic Acid Isolation & Purification Market

12.1. Introduction
12.2. Australia
12.3. China
12.4. India
12.5. Indonesia
12.6. Japan
12.7. Malaysia
12.8. Philippines
12.9. Singapore
12.10. South Korea
12.11. Taiwan
12.12. Thailand
12.13. Vietnam

13. Europe, Middle East & Africa Nucleic Acid Isolation & Purification Market

13.1. Introduction
13.2. Denmark
13.3. Egypt
13.4. Finland
13.5. France
13.6. Germany
13.7. Israel
13.8. Italy
13.9. Netherlands
13.10. Nigeria
13.11. Norway
13.12. Poland
13.13. Qatar
13.14. Russia
13.15. Saudi Arabia
13.16. South Africa
13.17. Spain
13.18. Sweden
13.19. Switzerland
13.20. Turkey
13.21. United Arab Emirates
13.22. United Kingdom

14. Competitive Landscape

14.1. Market Share Analysis, 2023
14.2. FPNV Positioning Matrix, 2023
14.3. Competitive Scenario Analysis
- 14.3.1. BioEcho Launches EchoLUTION FFPE DNA Kit for a Simplified DNA Extraction from FFPE Samples
- 14.3.2. Invitek Molecular acquired by ALS Limited
- 14.3.3. Bionano Genomics to Acquire Purigen Biosystems to Enable Further Simplified and Accelerated DNA Isolation for Optical Genome Mapping (OGM) and Address Difficult Sample Types in New Applications with Isotachophoresis (ITP) on the Ionic Purification System
14.4. Strategy Analysis & Recommendation

15. Competitive Portfolio

15.1. Key Company Profiles
15.2. Key Product Portfolio