PUBLISHER: The Business Research Company | PRODUCT CODE: 1957756
PUBLISHER: The Business Research Company | PRODUCT CODE: 1957756
Ribonucleic acid (RNA)-based oncolytic therapy is a cancer treatment that employs engineered RNA viruses to specifically target and destroy tumor cells. These viruses multiply within cancer cells, leading to their elimination and the release of tumor antigens. This process also activates the immune system to identify and attack any remaining cancer cells, improving overall anti-tumor effectiveness.
The primary therapy types of ribonucleic acid (RNA)-based oncolytic therapy include messenger ribonucleic acid (mRNA)-based oncolytic therapy, small interfering ribonucleic acid (siRNA)-based oncolytic therapy, micro ribonucleic acid (miRNA)-based oncolytic therapy, and other therapy types. Messenger ribonucleic acid (mRNA)-based oncolytic therapy involves the use of synthetic mRNA molecules designed to stimulate the immune system or directly trigger tumor cell death, providing a targeted and flexible approach to cancer treatment. These therapies are delivered via routes such as intravenous, intratumoral, and other methods, and are used in breast cancer, lung cancer, colorectal cancer, prostate cancer, melanoma, and other cancers. The main end-users include hospitals, cancer research institutes, specialty clinics, and others.
Tariffs are influencing the RNA-based oncolytic therapy market by increasing costs of imported nucleic acids, viral vectors, lipid nanoparticles, bioprocessing equipment, and cold-chain logistics systems. Cancer research institutes and hospitals in North America and Europe are most affected due to reliance on imported high-purity RNA materials, while Asia-Pacific faces higher costs in advanced therapy manufacturing. These tariffs are increasing development and trial costs and extending commercialization timelines. At the same time, they are encouraging domestic biomanufacturing, regional sourcing of RNA components, and investment in local advanced therapy production capabilities.
The ribonucleic acid (rna)-based oncolytic therapy market research report is one of a series of new reports from The Business Research Company that provides ribonucleic acid (rna)-based oncolytic therapy market statistics, including ribonucleic acid (rna)-based oncolytic therapy industry global market size, regional shares, competitors with a ribonucleic acid (rna)-based oncolytic therapy market share, detailed ribonucleic acid (rna)-based oncolytic therapy market segments, market trends and opportunities, and any further data you may need to thrive in the ribonucleic acid (rna)-based oncolytic therapy industry. This ribonucleic acid (rna)-based oncolytic therapy market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The ribonucleic acid (rna)-based oncolytic therapy market size has grown rapidly in recent years. It will grow from $2.12 billion in 2025 to $2.51 billion in 2026 at a compound annual growth rate (CAGR) of 18.7%. The growth in the historic period can be attributed to advancements in cancer virology research, increasing understanding of tumor immunology, availability of clinical trial infrastructure, rising oncology research funding, early success of oncolytic virus studies.
The ribonucleic acid (rna)-based oncolytic therapy market size is expected to see rapid growth in the next few years. It will grow to $4.94 billion in 2030 at a compound annual growth rate (CAGR) of 18.4%. The growth in the forecast period can be attributed to increasing approvals of rna-based cancer therapies, rising demand for personalized oncology treatments, expansion of immuno-oncology pipelines, growing investment in gene and cell therapies, technological advancements in rna delivery systems. Major trends in the forecast period include increasing advancement of rna virus engineering, rising adoption of combination oncolytic therapies, growing focus on immune system activation, expansion of targeted tumor-specific rna therapies, enhanced integration of precision oncology tools.
The increasing adoption of personalized medicine is anticipated to drive the growth of the RNA-based oncolytic therapy market in the coming years. Personalized medicine refers to treatments designed according to an individual's genetic profile, enhancing effectiveness and minimizing side effects. The use of personalized medicine is rising as more healthcare providers and institutions acknowledge its potential to improve patient outcomes through targeted therapies and precision diagnostics. RNA-based oncolytic therapy is pivotal in cancer care, supporting the adoption of personalized medicine by providing targeted, patient-specific treatment strategies. For example, in February 2024, the Personalized Medicine Coalition, a US-based advocacy organization for tailored medical treatments, reported that the FDA approved 16 new personalized therapies for rare disease patients in 2023, compared to 6 in 2022. Thus, the expanding adoption of personalized medicine is propelling the RNA-based oncolytic therapy market.
Major companies are active in the ribonucleic acid (RNA)-based oncolytic therapy market, concentrating on developing technological innovations such as synthetic messenger RNA (mRNA) technology to improve tumor-targeting efficiency, enhance immune response, and achieve more precise and long-lasting cancer treatment outcomes. Synthetic messenger RNA (mRNA) technology is a biotechnology method that creates and delivers lab-designed mRNA sequences to instruct cells to produce specific therapeutic proteins for disease management, including cancer. For example, in June 2024, CSPC Pharmaceutical Group Limited, a China-based pharmaceutical company, obtained regulatory approval in China to begin clinical trials for SYS6020, its synthetic mRNA-based cancer cell therapy. This milestone marks a significant advancement in the nation's messenger RNA therapeutics field. SYS6020 uses mRNA-lipid nanoparticle technology to selectively target and destroy myeloma cancer cells with minimal side effects, while also showing potential for treating certain autoimmune disorders.
In June 2023, Charles River Laboratories International, Inc., a US-based contract research organization (CRO), teamed up with Curigin Co., Ltd. to develop oncolytic RNAi gene therapy. Through this partnership, the goal is to accelerate the development and production of Curigin's RNAi-based oncolytic gene therapies by drawing on Charles River's CDMO expertise to aid preclinical and clinical trials. Curigin Co. Ltd. is a South Korea-based biotechnology company focused on creating RNA interference (RNAi)-based oncolytic gene therapies for cancer treatment.
Major companies operating in the ribonucleic acid (rna)-based oncolytic therapy market are AstraZeneca PLC, Moderna Inc., BioNTech SE, Gritstone Bio Inc., Orna Therapeutics Inc., Strand Therapeutics Inc., Oncolytics Biotech Inc., Anima Biotech Inc., eTheRNA immunotherapies NV, Vyriad Inc., Haya Therapeutics Inc., Virogin Biotech Inc., Providence Therapeutics Holdings Inc., Sirnaomics Inc., Humane Genomics Inc., Replicate Bioscience Inc., Abogen Biosciences Inc., Chimeron Bio Inc., Aro Biotherapeutics Inc., TransCode Therapeutics Inc.
North America was the largest region in the ribonucleic acid (RNA)-based oncolytic therapy market in 2025. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the ribonucleic acid (rna)-based oncolytic therapy market report are Asia-Pacific, South East Asia, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
The countries covered in the ribonucleic acid (rna)-based oncolytic therapy market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Taiwan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The ribonucleic acid (RNA)-based oncolytic therapy market includes revenues earned by entities through services such as clinical trials, tumor targeting, immune monitoring, patient support, and treatment administration. The market value includes the value of related goods sold by the service provider or included within the service offering. The ribonucleic acid (RNA)-based oncolytic therapy market also includes sales of RNA oncolytic viruses, viral vectors, delivery systems, formulations, and diagnostic kits. Values in this market are 'factory gate' values; that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Ribonucleic Acid (RNA)-Based Oncolytic Therapy Market Global Report 2026 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses ribonucleic acid (rna)-based oncolytic therapy market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for ribonucleic acid (rna)-based oncolytic therapy ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward, including technological disruption, regulatory shifts, and changing consumer preferences? The ribonucleic acid (rna)-based oncolytic therapy market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, total addressable market (TAM), market attractiveness score (MAS), competitive landscape, market shares, company scoring matrix, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
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