Intraoperative Radiation Therapy Market - Global Industry Size, Share, Trends, Opportunity, and Forecast, Segmented By Product, By Method, By Application, By End User, By Region & Competition, 2021-2031F

Description

The Global Intraoperative Radiation Therapy Market is projected to grow from USD 56.22 Million in 2025 to USD 77.74 Million by 2031, achieving a CAGR of 5.55%. Intraoperative Radiation Therapy (IORT) involves delivering a concentrated dose of radiation directly to the tumor bed during surgery, immediately following the resection of the malignancy. Primary drivers include the clinical ability to preserve healthy surrounding tissue and the significant reduction of treatment duration, often converting weeks of external therapy into a single operative session. This efficiency is critical as healthcare systems manage escalating demand; according to the World Health Organization's International Agency for Research on Cancer, updated 2024 estimates highlighted the growing global burden with approximately 20 million new cancer cases recorded in 2022.

Market Overview
Forecast Period	2027-2031
Market Size 2025	USD 56.22 Million
Market Size 2031	USD 77.74 Million
CAGR 2026-2031	5.55%
Fastest Growing Segment	Breast Cancer
Largest Market	North America

However, a significant challenge hindering market expansion is the high capital investment required for acquiring specialized radiation equipment and retrofitting operating rooms with necessary shielding. This financial barrier is further compounded by the stringent requirement for highly skilled multidisciplinary teams, including surgeons and physicists, to coordinate precisely within a sterile environment. These operational complexities, combined with inconsistent reimbursement policies in various international regions, limit the capacity of many healthcare facilities to adopt IORT technologies.

Market Driver

The escalating global prevalence of cancer cases acts as a primary catalyst for the Global Intraoperative Radiation Therapy Market, necessitating more efficient and scalable treatment modalities. As patient volumes rise, healthcare systems are compelled to adopt therapies that reduce surgical backlogs and treatment duration, such as IORT, which delivers concentrated radiation in a single operative session. This demand is particularly acute in breast oncology, where the burden is expanding rapidly; according to the International Agency for Research on Cancer, a study published in 'Nature Medicine' in February 2025 projected that by 2050, the annual global incidence will reach 3.2 million new breast cancer cases if current trends persist, underscoring the urgent necessity for expedited therapeutic techniques.

Technological advancements in portable and miniaturized IORT systems further propel market growth by eliminating the need for expensive, shielded operating bunkers, thereby lowering substantial adoption barriers for hospitals. Modern mobile units allow for precise radiation delivery directly in standard operating rooms, enhancing workflow versatility and operational efficiency. This shift towards accessible technology is reflected in the financial performance of key industry innovators; according to Sensus Healthcare's 'Fourth Quarter and Full Year 2024 Financial Results' from February 2025, the company reported a 71% increase in full-year revenue to $41.8 million driven by its radiation therapy portfolio, while Carl Zeiss Meditec AG's 'Annual Report 2024/25' from December 2025 showed a total revenue of €2,227.6 million, highlighting the robust industrial scale supporting these advanced solutions.

Market Challenge

The substantial capital expenditure required for acquiring specialized equipment and retrofitting operating rooms stands as a formidable barrier to the growth of the Global Intraoperative Radiation Therapy Market. Healthcare facilities face significant upfront costs to install necessary shielding and procure high-tech radiation devices, which limits adoption primarily to large, well-funded academic centers. This restriction prevents widespread market penetration, as smaller hospitals often lack the budget to support such capital-intensive projects. Additionally, the operational complexity of coordinating highly skilled multidisciplinary teams within sterile environments adds to the resource burden, further deterring potential buyers.

This financial challenge is critically aggravated by declining reimbursement rates, which extend the return on investment period and reduce the economic viability of adopting new radiation technologies. According to the American Society for Radiation Oncology in 2025, payment reductions for radiation oncology services under the Medicare Physician Fee Schedule have reached 25% since 2013. Such consistent decreases in financial support make it increasingly difficult for healthcare providers to justify the heavy investment needed for intraoperative systems, thereby directly stifling market expansion.

Market Trends

The expansion of clinical applications to neuro-oncology and gastrointestinal cancers is significantly broadening the addressable patient base for the Global Intraoperative Radiation Therapy Market beyond its traditional stronghold in breast conservation. Medical device manufacturers are increasingly tailoring brachytherapy solutions to treat complex, deep-seated tumors such as glioblastomas and brain metastases, where precise, immediate radiation is crucial to prevent local failure. This shift is supported by clinical data; according to the 'Collagen Implant May Improve Local Control of Metastatic Brain Tumors' report in CancerNetwork (October 2025), interim findings from the Phase 3 ROADS trial indicated that GammaTile therapy reduced the risk of tumor recurrence or death by more than 50% compared to standard stereotactic radiotherapy in patients with newly diagnosed brain metastases.

Simultaneously, the emergence of robotic-assisted intraoperative radiation delivery is addressing the critical need for geometric precision when treating malignancies located near vital vascular structures. The integration of robotic positioning systems with radiation delivery devices allows oncologists to navigate difficult anatomical constraints, particularly in abdominal cancers, maximizing dose conformity while sparing healthy tissue. This technological synergy is demonstrating remarkable improvements; according to the 'Preliminary study shows intraoperative radiation's success against pancreatic cancer spread' article on News-Medical.net (October 2025), investigators at Johns Hopkins reported that utilizing a robotic device for targeted intraoperative radiation effectively reduced the recurrence rate around the pancreas to just 5% in patients with locally advanced pancreatic cancer.

Key Market Players

IntraOp Medical, Inc
iCAD, Inc.
Elekta AB
Sensus Healthcare, Inc.
Isoray, Inc.
Becton, Dickinson and Company
Sordina IORT Technologies
Varian Medical Systems, Inc.
SeeDos Ltd.
IsoAid LLC

Report Scope

In this report, the Global Intraoperative Radiation Therapy Market has been segmented into the following categories, in addition to the industry trends which have also been detailed below:

Intraoperative Radiation Therapy Market, By Product

Intraoperative Radiation Therapy Devices
Intraoperative Radiation Therapy Accessories
Software
Services

Intraoperative Radiation Therapy Market, By Method

Electron
Intraoperative Brachytherapy
High Dose-Rate
X-Ray
Others

Intraoperative Radiation Therapy Market, By Application

Breast Cancer
Brain Tumor
Head and Neck Cancer
Soft Tissue Sarcoma
Pediatric Tumors
Gynecological Cancer
Genitourinary Cancers
Others

Intraoperative Radiation Therapy Market, By End User

Hospitals & Clinics
Ambulatory Care Centers
Others

Intraoperative Radiation Therapy Market, By Region

North America
- United States
- Canada
- Mexico
Europe
- France
- United Kingdom
- Italy
- Germany
- Spain
Asia Pacific
- China
- India
- Japan
- Australia
- South Korea
South America
- Brazil
- Argentina
- Colombia
Middle East & Africa
- South Africa
- Saudi Arabia
- UAE

Competitive Landscape

Company Profiles: Detailed analysis of the major companies present in the Global Intraoperative Radiation Therapy Market.

Available Customizations:

Global Intraoperative Radiation Therapy Market report with the given market data, TechSci Research offers customizations according to a company's specific needs. The following customization options are available for the report:

1. Product Overview

1.1. Market Definition
1.2. Scope of the Market
- 1.2.1. Markets Covered
- 1.2.2. Years Considered for Study
- 1.2.3. Key Market Segmentations

2. Research Methodology

2.1. Objective of the Study
2.2. Baseline Methodology
2.3. Key Industry Partners
2.4. Major Association and Secondary Sources
2.5. Forecasting Methodology
2.6. Data Triangulation & Validation
2.7. Assumptions and Limitations

3. Executive Summary

3.1. Overview of the Market
3.2. Overview of Key Market Segmentations
3.3. Overview of Key Market Players
3.4. Overview of Key Regions/Countries
3.5. Overview of Market Drivers, Challenges, Trends

4. Voice of Customer

5. Global Intraoperative Radiation Therapy Market Outlook

5.1. Market Size & Forecast
- 5.1.1. By Value
5.2. Market Share & Forecast
- 5.2.1. By Product (Intraoperative Radiation Therapy Devices, Intraoperative Radiation Therapy Accessories, Software, Services)
- 5.2.2. By Method (Electron, Intraoperative Brachytherapy, High Dose-Rate, X-Ray, Others)
- 5.2.3. By Application (Breast Cancer, Brain Tumor, Head and Neck Cancer, Soft Tissue Sarcoma, Pediatric Tumors, Gynecological Cancer, Genitourinary Cancers, Others)
- 5.2.4. By End User (Hospitals & Clinics, Ambulatory Care Centers, Others)
- 5.2.5. By Region
- 5.2.6. By Company (2025)
5.3. Market Map

6. North America Intraoperative Radiation Therapy Market Outlook

6.1. Market Size & Forecast
- 6.1.1. By Value
6.2. Market Share & Forecast
- 6.2.1. By Product
- 6.2.2. By Method
- 6.2.3. By Application
- 6.2.4. By End User
- 6.2.5. By Country
6.3. North America: Country Analysis
- 6.3.1. United States Intraoperative Radiation Therapy Market Outlook
  - 6.3.1.1. Market Size & Forecast
    - 6.3.1.1.1. By Value
  - 6.3.1.2. Market Share & Forecast
    - 6.3.1.2.1. By Product
    - 6.3.1.2.2. By Method
    - 6.3.1.2.3. By Application
    - 6.3.1.2.4. By End User
- 6.3.2. Canada Intraoperative Radiation Therapy Market Outlook
  - 6.3.2.1. Market Size & Forecast
    - 6.3.2.1.1. By Value
  - 6.3.2.2. Market Share & Forecast
    - 6.3.2.2.1. By Product
    - 6.3.2.2.2. By Method
    - 6.3.2.2.3. By Application
    - 6.3.2.2.4. By End User
- 6.3.3. Mexico Intraoperative Radiation Therapy Market Outlook
  - 6.3.3.1. Market Size & Forecast
    - 6.3.3.1.1. By Value
  - 6.3.3.2. Market Share & Forecast
    - 6.3.3.2.1. By Product
    - 6.3.3.2.2. By Method
    - 6.3.3.2.3. By Application
    - 6.3.3.2.4. By End User

7. Europe Intraoperative Radiation Therapy Market Outlook

7.1. Market Size & Forecast
- 7.1.1. By Value
7.2. Market Share & Forecast
- 7.2.1. By Product
- 7.2.2. By Method
- 7.2.3. By Application
- 7.2.4. By End User
- 7.2.5. By Country
7.3. Europe: Country Analysis
- 7.3.1. Germany Intraoperative Radiation Therapy Market Outlook
  - 7.3.1.1. Market Size & Forecast
    - 7.3.1.1.1. By Value
  - 7.3.1.2. Market Share & Forecast
    - 7.3.1.2.1. By Product
    - 7.3.1.2.2. By Method
    - 7.3.1.2.3. By Application
    - 7.3.1.2.4. By End User
- 7.3.2. France Intraoperative Radiation Therapy Market Outlook
  - 7.3.2.1. Market Size & Forecast
    - 7.3.2.1.1. By Value
  - 7.3.2.2. Market Share & Forecast
    - 7.3.2.2.1. By Product
    - 7.3.2.2.2. By Method
    - 7.3.2.2.3. By Application
    - 7.3.2.2.4. By End User
- 7.3.3. United Kingdom Intraoperative Radiation Therapy Market Outlook
  - 7.3.3.1. Market Size & Forecast
    - 7.3.3.1.1. By Value
  - 7.3.3.2. Market Share & Forecast
    - 7.3.3.2.1. By Product
    - 7.3.3.2.2. By Method
    - 7.3.3.2.3. By Application
    - 7.3.3.2.4. By End User
- 7.3.4. Italy Intraoperative Radiation Therapy Market Outlook
  - 7.3.4.1. Market Size & Forecast
    - 7.3.4.1.1. By Value
  - 7.3.4.2. Market Share & Forecast
    - 7.3.4.2.1. By Product
    - 7.3.4.2.2. By Method
    - 7.3.4.2.3. By Application
    - 7.3.4.2.4. By End User
- 7.3.5. Spain Intraoperative Radiation Therapy Market Outlook
  - 7.3.5.1. Market Size & Forecast
    - 7.3.5.1.1. By Value
  - 7.3.5.2. Market Share & Forecast
    - 7.3.5.2.1. By Product
    - 7.3.5.2.2. By Method
    - 7.3.5.2.3. By Application
    - 7.3.5.2.4. By End User

8. Asia Pacific Intraoperative Radiation Therapy Market Outlook

8.1. Market Size & Forecast
- 8.1.1. By Value
8.2. Market Share & Forecast
- 8.2.1. By Product
- 8.2.2. By Method
- 8.2.3. By Application
- 8.2.4. By End User
- 8.2.5. By Country
8.3. Asia Pacific: Country Analysis
- 8.3.1. China Intraoperative Radiation Therapy Market Outlook
  - 8.3.1.1. Market Size & Forecast
    - 8.3.1.1.1. By Value
  - 8.3.1.2. Market Share & Forecast
    - 8.3.1.2.1. By Product
    - 8.3.1.2.2. By Method
    - 8.3.1.2.3. By Application
    - 8.3.1.2.4. By End User
- 8.3.2. India Intraoperative Radiation Therapy Market Outlook
  - 8.3.2.1. Market Size & Forecast
    - 8.3.2.1.1. By Value
  - 8.3.2.2. Market Share & Forecast
    - 8.3.2.2.1. By Product
    - 8.3.2.2.2. By Method
    - 8.3.2.2.3. By Application
    - 8.3.2.2.4. By End User
- 8.3.3. Japan Intraoperative Radiation Therapy Market Outlook
  - 8.3.3.1. Market Size & Forecast
    - 8.3.3.1.1. By Value
  - 8.3.3.2. Market Share & Forecast
    - 8.3.3.2.1. By Product
    - 8.3.3.2.2. By Method
    - 8.3.3.2.3. By Application
    - 8.3.3.2.4. By End User
- 8.3.4. South Korea Intraoperative Radiation Therapy Market Outlook
  - 8.3.4.1. Market Size & Forecast
    - 8.3.4.1.1. By Value
  - 8.3.4.2. Market Share & Forecast
    - 8.3.4.2.1. By Product
    - 8.3.4.2.2. By Method
    - 8.3.4.2.3. By Application
    - 8.3.4.2.4. By End User
- 8.3.5. Australia Intraoperative Radiation Therapy Market Outlook
  - 8.3.5.1. Market Size & Forecast
    - 8.3.5.1.1. By Value
  - 8.3.5.2. Market Share & Forecast
    - 8.3.5.2.1. By Product
    - 8.3.5.2.2. By Method
    - 8.3.5.2.3. By Application
    - 8.3.5.2.4. By End User

9. Middle East & Africa Intraoperative Radiation Therapy Market Outlook

9.1. Market Size & Forecast
- 9.1.1. By Value
9.2. Market Share & Forecast
- 9.2.1. By Product
- 9.2.2. By Method
- 9.2.3. By Application
- 9.2.4. By End User
- 9.2.5. By Country
9.3. Middle East & Africa: Country Analysis
- 9.3.1. Saudi Arabia Intraoperative Radiation Therapy Market Outlook
  - 9.3.1.1. Market Size & Forecast
    - 9.3.1.1.1. By Value
  - 9.3.1.2. Market Share & Forecast
    - 9.3.1.2.1. By Product
    - 9.3.1.2.2. By Method
    - 9.3.1.2.3. By Application
    - 9.3.1.2.4. By End User
- 9.3.2. UAE Intraoperative Radiation Therapy Market Outlook
  - 9.3.2.1. Market Size & Forecast
    - 9.3.2.1.1. By Value
  - 9.3.2.2. Market Share & Forecast
    - 9.3.2.2.1. By Product
    - 9.3.2.2.2. By Method
    - 9.3.2.2.3. By Application
    - 9.3.2.2.4. By End User
- 9.3.3. South Africa Intraoperative Radiation Therapy Market Outlook
  - 9.3.3.1. Market Size & Forecast
    - 9.3.3.1.1. By Value
  - 9.3.3.2. Market Share & Forecast
    - 9.3.3.2.1. By Product
    - 9.3.3.2.2. By Method
    - 9.3.3.2.3. By Application
    - 9.3.3.2.4. By End User

10. South America Intraoperative Radiation Therapy Market Outlook

10.1. Market Size & Forecast
- 10.1.1. By Value
10.2. Market Share & Forecast
- 10.2.1. By Product
- 10.2.2. By Method
- 10.2.3. By Application
- 10.2.4. By End User
- 10.2.5. By Country
10.3. South America: Country Analysis
- 10.3.1. Brazil Intraoperative Radiation Therapy Market Outlook
  - 10.3.1.1. Market Size & Forecast
    - 10.3.1.1.1. By Value
  - 10.3.1.2. Market Share & Forecast
    - 10.3.1.2.1. By Product
    - 10.3.1.2.2. By Method
    - 10.3.1.2.3. By Application
    - 10.3.1.2.4. By End User
- 10.3.2. Colombia Intraoperative Radiation Therapy Market Outlook
  - 10.3.2.1. Market Size & Forecast
    - 10.3.2.1.1. By Value
  - 10.3.2.2. Market Share & Forecast
    - 10.3.2.2.1. By Product
    - 10.3.2.2.2. By Method
    - 10.3.2.2.3. By Application
    - 10.3.2.2.4. By End User
- 10.3.3. Argentina Intraoperative Radiation Therapy Market Outlook
  - 10.3.3.1. Market Size & Forecast
    - 10.3.3.1.1. By Value
  - 10.3.3.2. Market Share & Forecast
    - 10.3.3.2.1. By Product
    - 10.3.3.2.2. By Method
    - 10.3.3.2.3. By Application
    - 10.3.3.2.4. By End User

11. Market Dynamics

11.1. Drivers
11.2. Challenges

12. Market Trends & Developments

12.1. Merger & Acquisition (If Any)
12.2. Product Launches (If Any)
12.3. Recent Developments

13. Global Intraoperative Radiation Therapy Market: SWOT Analysis

14. Porter's Five Forces Analysis

14.1. Competition in the Industry
14.2. Potential of New Entrants
14.3. Power of Suppliers
14.4. Power of Customers
14.5. Threat of Substitute Products

15. Competitive Landscape

15.1. IntraOp Medical, Inc
- 15.1.1. Business Overview
- 15.1.2. Products & Services
- 15.1.3. Recent Developments
- 15.1.4. Key Personnel
- 15.1.5. SWOT Analysis
15.2. iCAD, Inc.
15.3. Elekta AB
15.4. Sensus Healthcare, Inc.
15.5. Isoray, Inc.
15.6. Becton, Dickinson and Company
15.7. Sordina IORT Technologies
15.8. Varian Medical Systems, Inc.
15.9. SeeDos Ltd.
15.10. IsoAid LLC