PUBLISHER: Grand View Research | PRODUCT CODE: 1888867
PUBLISHER: Grand View Research | PRODUCT CODE: 1888867
The global RNAi technology market size was estimated at USD 2.94 billion in 2024 and is projected to reach USD 9.52 billion by 2033, growing at a CAGR of 14.25% from 2025 to 2033. This market growth is attributed to the increasing prevalence of autoimmune diseases, rare disorders, and cancer across the globe.
Expansion of RNAi-Based Therapeutics
The RNAi technology market is growing rapidly due to strong clinical validation and multiple FDA/EMA approvals, including ONPATTRO, GIVLAARI, OXLUMO, and AMVUTTRA. These approvals have proven that RNAi can be developed into safe and effective therapeutics, boosting confidence among biopharma companies and accelerating investment in RNAi platforms. Its ability to precisely silence disease-causing genes makes RNAi a transformative option for rare genetic and liver-targeted disorders. As approved RNAi therapies show strong clinical and commercial performance, demand for RNAi tools, reagents, and delivery technologies continues to rise.
The growth of the market is being further accelerated by significant pharmaceutical interest. Through partnerships, acquisitions, and internal research and development, businesses such as Alnylam, Arrowhead, Dicerna (Novo Nordisk), AstraZeneca, and Takeda are growing their RNAi pipelines. Through these initiatives, RNAi applications are expanding into the fields of oncology, infectious diseases, and cardiometabolic disorders. Significant investments, enduring collaborations, and specialized RNAi research facilities are propelling clinical activity, product launches, and ongoing innovation. The need for RNAi platforms in drug discovery and clinical development keeps growing as the therapeutic pipeline broadens and industry investment increases.
Advancements in Delivery Technologies
Advances in RNAi delivery systems have become a key growth driver for the RNAi technology industry. Earlier issues, such as poor uptake, rapid degradation, and off-target effects, have been largely addressed through innovations in LNPs, GalNAc-siRNA conjugates, polymer carriers, and viral vectors. These next-generation platforms enhance stability, biodistribution, and tissue-specific targeting, particularly in the liver, a major site for genetic and metabolic disorders. As delivery becomes more efficient and clinically viable, demand for RNAi reagents, delivery kits, and development solutions continues to increase.
In addition, RNAi is expanding beyond liver targets owing to advanced delivery technologies. New strategies, such as targeted nanoparticles, peptide-based carriers, and engineered exosomes, are creating opportunities for applications in infectious diseases, cancer, and the central nervous system. To improve their pipelines and lower development risk, biopharma companies are making significant investments in these delivery innovations.
Global RNAi Technology Market Report Segmentation
This report forecasts revenue growth and provides an analysis on the latest trends in each of the sub-segments from 2021 to 2033. For this report, Grand View Research has segmented the global RNAi technology market report on the basis of product & service, application, end use, and region: